HUT75869A - Benzoylecgonine, ecgonine and ecgonidine derivatives - Google Patents

Benzoylecgonine, ecgonine and ecgonidine derivatives

Info

Publication number
HUT75869A
HUT75869A HU9603443A HU9603443A HUT75869A HU T75869 A HUT75869 A HU T75869A HU 9603443 A HU9603443 A HU 9603443A HU 9603443 A HU9603443 A HU 9603443A HU T75869 A HUT75869 A HU T75869A
Authority
HU
Hungary
Prior art keywords
disorders
ecgonine
benzoylecgonine
ecgonidine derivatives
relates
Prior art date
Application number
HU9603443A
Other languages
English (en)
Other versions
HU224634B1 (hu
HU9603443D0 (en
Inventor
Lowell M Somers
James E Wynn
Original Assignee
Entropin Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entropin Inc filed Critical Entropin Inc
Publication of HU9603443D0 publication Critical patent/HU9603443D0/hu
Publication of HUT75869A publication Critical patent/HUT75869A/hu
Publication of HU224634B1 publication Critical patent/HU224634B1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/12Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Non-Portable Lighting Devices Or Systems Thereof (AREA)
  • Materials For Medical Uses (AREA)
HU9603443A 1994-06-16 1995-06-07 Benzoil-ekgonin-származékok és ezeket tartalmazó gyógyszerkészítmények HU224634B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/260,054 US5525613A (en) 1994-06-16 1994-06-16 Covalently coupled benzoylecgonine ecgonine and ecgonidine

Publications (3)

Publication Number Publication Date
HU9603443D0 HU9603443D0 (en) 1997-02-28
HUT75869A true HUT75869A (en) 1997-05-28
HU224634B1 HU224634B1 (hu) 2005-12-28

Family

ID=22987610

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9603443A HU224634B1 (hu) 1994-06-16 1995-06-07 Benzoil-ekgonin-származékok és ezeket tartalmazó gyógyszerkészítmények

Country Status (21)

Country Link
US (1) US5525613A (hu)
EP (2) EP0765326B1 (hu)
JP (1) JP2951409B2 (hu)
KR (1) KR100407458B1 (hu)
CN (1) CN1046511C (hu)
AT (1) ATE255108T1 (hu)
AU (1) AU693571B2 (hu)
CA (1) CA2190611A1 (hu)
DE (1) DE69532203T2 (hu)
DK (1) DK0765326T3 (hu)
ES (1) ES2210296T3 (hu)
HK (1) HK1012626A1 (hu)
HU (1) HU224634B1 (hu)
IL (1) IL114177A (hu)
MX (1) MX9606374A (hu)
NO (1) NO965276D0 (hu)
NZ (1) NZ288844A (hu)
PL (1) PL186000B1 (hu)
PT (1) PT765326E (hu)
WO (1) WO1995034561A1 (hu)
ZA (1) ZA955002B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270766B1 (en) * 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
US5763456A (en) * 1995-06-07 1998-06-09 Entropin, Inc. Benzoylecgonine, ecgonine and ecgonidine derivatives
US6482831B1 (en) 1994-06-16 2002-11-19 Entropin, Inc. Covalently coupled benzoylecgonine, egconine and ecgonidine derivatives
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
CA2466062A1 (en) 2001-11-13 2003-05-22 Entropin, Inc. Novel benzoylecgonine compositions and methods for producing them
TW200418856A (en) * 2002-12-05 2004-10-01 Entropin Inc Novel tropane esters and methods for producing and using them
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
WO2007137030A2 (en) 2006-05-19 2007-11-29 Abbott Laboratories Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893996A (en) * 1957-10-14 1959-07-07 Grace W R & Co N-amino derivatives of tropine alkaloids
US2948730A (en) * 1959-02-04 1960-08-09 Grace W R & Co 8-aminotropanium compounds
US4469700A (en) * 1981-06-19 1984-09-04 Lowell M. Somers Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis
US4556663A (en) * 1982-12-13 1985-12-03 Somers Lowell M Benzoylecgonine, benzoylnorecgonine and ecgonine as active agents for the treatment of rheumatoid arthritis and osteoarthritis
US4512996A (en) * 1982-12-13 1985-04-23 Lowell Somers Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis
FR2569563B1 (fr) * 1984-09-03 1987-07-03 Somers Lowell Formulation a base de benzoylecgonine ou de benzoylnorecgonine pour le traitement du rhumatisme articulaire
US5376667A (en) * 1992-12-31 1994-12-27 Entropin, Inc. Derivatives of benzoylecgonine, ecgonine and their multiple pharmacological properties

Also Published As

Publication number Publication date
MX9606374A (es) 1997-03-29
HU224634B1 (hu) 2005-12-28
NZ288844A (en) 1998-05-27
US5525613A (en) 1996-06-11
EP1466913A1 (en) 2004-10-13
HK1012626A1 (en) 1999-08-06
PL186000B1 (pl) 2003-09-30
AU693571B2 (en) 1998-07-02
CN1046511C (zh) 1999-11-17
DK0765326T3 (da) 2004-04-05
KR100407458B1 (ko) 2004-03-26
ATE255108T1 (de) 2003-12-15
CA2190611A1 (en) 1995-12-21
IL114177A (en) 2000-02-17
HU9603443D0 (en) 1997-02-28
PL317754A1 (en) 1997-04-28
CN1150802A (zh) 1997-05-28
JPH09510991A (ja) 1997-11-04
EP0765326B1 (en) 2003-11-26
NO965276L (no) 1996-12-10
ES2210296T3 (es) 2004-07-01
NO965276D0 (no) 1996-12-10
PT765326E (pt) 2004-03-31
DE69532203T2 (de) 2004-09-09
DE69532203D1 (de) 2004-01-08
EP0765326A1 (en) 1997-04-02
AU2820095A (en) 1996-01-05
ZA955002B (en) 1996-02-08
IL114177A0 (en) 1995-10-31
JP2951409B2 (ja) 1999-09-20
WO1995034561A1 (en) 1995-12-21

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20051019

MM4A Lapse of definitive patent protection due to non-payment of fees