HUT68820A - Process to prepare pharmaceutical compns. contg. optically pure r(-)ketoprofen with antipyretic and analgesic activity - Google Patents
Process to prepare pharmaceutical compns. contg. optically pure r(-)ketoprofen with antipyretic and analgesic activityInfo
- Publication number
- HUT68820A HUT68820A HU9402594A HU9402594A HUT68820A HU T68820 A HUT68820 A HU T68820A HU 9402594 A HU9402594 A HU 9402594A HU 9402594 A HU9402594 A HU 9402594A HU T68820 A HUT68820 A HU T68820A
- Authority
- HU
- Hungary
- Prior art keywords
- antipyretic
- ketoprofen
- contg
- optically pure
- analgesic activity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Accessories For Mixers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84845892A | 1992-03-09 | 1992-03-09 | |
US08/024,728 US5331000A (en) | 1992-03-09 | 1993-03-01 | Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen |
Publications (2)
Publication Number | Publication Date |
---|---|
HU9402594D0 HU9402594D0 (en) | 1994-11-28 |
HUT68820A true HUT68820A (en) | 1995-07-28 |
Family
ID=26698799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9402594A HUT68820A (en) | 1992-03-09 | 1993-03-08 | Process to prepare pharmaceutical compns. contg. optically pure r(-)ketoprofen with antipyretic and analgesic activity |
Country Status (10)
Country | Link |
---|---|
US (1) | US5331000A (hu) |
EP (1) | EP0630239A4 (hu) |
JP (1) | JPH07507057A (hu) |
AU (2) | AU673998B2 (hu) |
BR (1) | BR9306067A (hu) |
CA (2) | CA2131802A1 (hu) |
HU (1) | HUT68820A (hu) |
NZ (1) | NZ251138A (hu) |
RU (1) | RU2125873C1 (hu) |
WO (1) | WO1993017677A1 (hu) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2671800B1 (fr) * | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
US5786357A (en) | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
US5981591A (en) * | 1992-12-04 | 1999-11-09 | Mayor Pharmaceutical Laboratories, Inc. | Sprayable analgesic composition and method of use |
US5808069A (en) * | 1993-03-09 | 1998-09-15 | Dompe' Farmaceutici Spa | Salts of 2-(3-benzoylphenyl) propionic acid with organic bases and pharmaceutical compositions thereof |
DE4319438C1 (de) * | 1993-06-11 | 1994-06-01 | Gerd Dr Dr Geislinger | Arzneimittel auf der Grundlage von Ketoprofen zur Bekämpfung von Schmerzen und/oder Entzündungen und/oder Fieber an Menschen und Tieren |
EP0785779A1 (en) * | 1994-03-18 | 1997-07-30 | Bayer Corporation | Low dosage ketoprofen |
JPH08151344A (ja) * | 1994-09-26 | 1996-06-11 | Nagase & Co Ltd | 2−(3−ベンゾイルフェニル)プロピオン酸の光学分割方法 |
US5955504A (en) * | 1995-03-13 | 1999-09-21 | Loma Linda University Medical Center | Colorectal chemoprotective composition and method of preventing colorectal cancer |
US5981592A (en) * | 1995-03-13 | 1999-11-09 | Loma Linda University Medical Center | Method and composition for treating cystic fibrosis |
US6160018A (en) * | 1995-03-13 | 2000-12-12 | Loma Linda University Medical Center | Prophylactic composition and method for alzheimer's Disease |
US6355656B1 (en) | 1995-12-04 | 2002-03-12 | Celgene Corporation | Phenidate drug formulations having diminished abuse potential |
US5908850A (en) * | 1995-12-04 | 1999-06-01 | Celgene Corporation | Method of treating attention deficit disorders with d-threo methylphenidate |
US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
US5733756A (en) * | 1996-01-05 | 1998-03-31 | Celgene Corporation | Lactams and processes for stereoselective enrichment of lactams, amides, and esters |
US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
FR2742054B1 (fr) * | 1995-12-06 | 1998-01-09 | Synthelabo | Compositions pharmaceutiques contenant un agent anti-inflammatoire et des ceramides vegetales |
IT1277741B1 (it) * | 1995-12-28 | 1997-11-12 | Dompe Spa | Composizioni farmaceutiche parenterali contenenti sali di alchilammonio di acidi 2-arilpropionici |
US6767925B1 (en) | 1996-10-31 | 2004-07-27 | Joseph A. Deihl | Sprayable analgesic composition and method of use |
DE69841267D1 (de) * | 1997-03-10 | 2009-12-10 | Univ Loma Linda Med | Verwendung von r-carprofen zur Vorbeugung der Alzheimerschen Krankheit |
US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
IT1298214B1 (it) * | 1998-01-28 | 1999-12-20 | Dompe Spa | Sali dell'acido (r) 2-(3-benzoilfenil) propionico e loro composizioni farmaceutiche. |
US6197347B1 (en) | 1998-06-29 | 2001-03-06 | Andrx Pharmaceuticals, Inc. | Oral dosage for the controlled release of analgesic |
GB2339534A (en) * | 1998-07-16 | 2000-02-02 | Edko Trading Representation | Epidural or intrathecal administration of NSAID's |
EP1143958B8 (en) * | 1998-09-03 | 2007-05-23 | Loma Linda University Medical Center | Pharmaceutical composition and use of rnsaid for treating inflammation |
US7067144B2 (en) | 1998-10-20 | 2006-06-27 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
US6362227B1 (en) * | 1999-03-02 | 2002-03-26 | Sepracor, Inc. | Methods for the treatment of tinnitus and other disorders using R(−)ketoptofen |
EP1284729A4 (en) * | 2000-04-13 | 2007-12-19 | Mayo Foundation | REDUCTION AGENTS OF A (BETA) 42 |
CN100588395C (zh) * | 2000-06-13 | 2010-02-10 | Wyeth公司 | 含有环氧化酶-2抑制剂的止痛和抗炎药物 |
DE10047319A1 (de) | 2000-09-25 | 2002-04-18 | Paz Arzneimittelentwicklung | Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen, welche durch die Hemmung der Aktivierung des nukleären Transkriptionsfaktors AP-1 therapeutisch beeinflußt werden können |
US6534676B2 (en) * | 2001-01-31 | 2003-03-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method to treat chronic heart failure and/or elevated cholesterol levels using 3,5-diiodothyropropionic acid and method to prepare same |
US20030027867A1 (en) * | 2001-06-29 | 2003-02-06 | Myriad Genetics, Incorporated | Use of R-NSAID compounds for anti-HIV treatment |
FR2833173B1 (fr) * | 2001-12-10 | 2004-08-27 | Roquette Freres | Preparation antipyretique renfermant du xylitol |
WO2004071431A2 (en) * | 2003-02-05 | 2004-08-26 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
US20050042284A1 (en) * | 2003-07-11 | 2005-02-24 | Myriad Genetics, Incorporated | Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease |
WO2006001877A2 (en) * | 2004-04-13 | 2006-01-05 | Myriad Genetics, Inc. | Combination treatment for neurodegenerative disorders comprising r-flurbiprofen |
US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
MXPA06012165A (es) * | 2004-04-29 | 2007-01-17 | Keystone Retaining Wall System | Chapas para muros, muros de contencion y similares. |
US7666914B2 (en) * | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
BRPI0514303A (pt) * | 2004-08-11 | 2008-06-10 | Myriad Genetics Inc | composição farmacêutica e método para tratar distúrbios neurodegenerativos |
EP1830648A4 (en) * | 2004-12-09 | 2008-03-12 | Celgene Corp | TREATMENT WITH D-THREO-METHYLPHENIDATE |
AU2006265008A1 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and O-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
EP1909777A2 (en) * | 2005-07-22 | 2008-04-16 | Myriad Genetics, Inc. | High drug load formulations and dosage forms |
WO2008006099A2 (en) * | 2006-07-07 | 2008-01-10 | Myriad Genetics, Inc. | Treatment of psychiatric disorders |
US20090238763A1 (en) * | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
WO2008012605A1 (en) * | 2006-07-27 | 2008-01-31 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ketoprofen and related compounds with very fast skin penetration rate |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
CN105820107B (zh) * | 2007-06-04 | 2022-09-09 | 泰飞尔公司 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途 |
US20080305171A1 (en) * | 2007-06-07 | 2008-12-11 | Kristin Anne Arnold | Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there |
KR102225999B1 (ko) * | 2008-12-04 | 2021-03-10 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
EP3907214A1 (en) * | 2020-05-04 | 2021-11-10 | Dompe' Farmaceutici S.P.A. | Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1546478A (fr) * | 1967-01-27 | 1968-11-22 | Rhone Poulenc Sa | Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation |
US4962124A (en) * | 1987-11-17 | 1990-10-09 | Analgesic Associates | Onset-hastened/enhanced antipyretic response |
US4868214A (en) * | 1987-11-17 | 1989-09-19 | Analgesic Associates | Onset-hastened/enhanced analgesia |
US4927854A (en) * | 1987-12-24 | 1990-05-22 | Analgesic Associates | Sustained/enhanced analgesia |
US5057427A (en) * | 1988-04-07 | 1991-10-15 | Sepracor, Inc. | Method for resolution of stereoisomers |
DE3814887C1 (hu) * | 1988-05-02 | 1989-09-21 | Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De | |
SU1687678A1 (ru) * | 1988-08-02 | 1991-10-30 | Предприятие П/Я А-7650 | Швейна машина |
FR2651494B1 (fr) * | 1989-09-05 | 1993-01-08 | Rhone Poulenc Sante | Procede de preparation d'acides aryl-2 propioniques optiquement actifs. |
US5114715A (en) * | 1990-11-29 | 1992-05-19 | Sepracor Inc. | Methods of use and compositions of (s)-isoflurane and (s)-desflurane |
US5114714A (en) * | 1990-11-29 | 1992-05-19 | Sepracor, Inc. | Methods of use and compositions of (r)-isoflurane and (r)-desflurane |
FR2687915B1 (fr) * | 1992-02-28 | 1995-05-05 | Rhone Poulenc Rorer Sa | Composition pharmaceutique utilisable comme analgesique contenant l'acide (benzoyl-3 phenyl)-2 propionique-(r). |
DE4319438C1 (de) * | 1993-06-11 | 1994-06-01 | Gerd Dr Dr Geislinger | Arzneimittel auf der Grundlage von Ketoprofen zur Bekämpfung von Schmerzen und/oder Entzündungen und/oder Fieber an Menschen und Tieren |
-
1993
- 1993-03-01 US US08/024,728 patent/US5331000A/en not_active Expired - Lifetime
- 1993-03-08 CA CA002131802A patent/CA2131802A1/en not_active Abandoned
- 1993-03-08 RU RU94042899A patent/RU2125873C1/ru active
- 1993-03-08 JP JP5515969A patent/JPH07507057A/ja active Pending
- 1993-03-08 NZ NZ251138A patent/NZ251138A/en unknown
- 1993-03-08 BR BR9306067A patent/BR9306067A/pt not_active Application Discontinuation
- 1993-03-08 WO PCT/US1993/002126 patent/WO1993017677A1/en not_active Application Discontinuation
- 1993-03-08 HU HU9402594A patent/HUT68820A/hu unknown
- 1993-03-08 EP EP93907353A patent/EP0630239A4/en not_active Withdrawn
- 1993-03-08 AU AU37989/93A patent/AU673998B2/en not_active Ceased
- 1993-04-22 CA CA002094683A patent/CA2094683A1/en not_active Abandoned
-
1996
- 1996-10-23 AU AU70334/96A patent/AU690860B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0630239A1 (en) | 1994-12-28 |
AU3798993A (en) | 1993-10-05 |
HU9402594D0 (en) | 1994-11-28 |
WO1993017677A1 (en) | 1993-09-16 |
CA2131802A1 (en) | 1993-09-16 |
AU690860B2 (en) | 1998-04-30 |
US5331000A (en) | 1994-07-19 |
AU673998B2 (en) | 1996-12-05 |
JPH07507057A (ja) | 1995-08-03 |
RU94042899A (ru) | 1996-10-20 |
CA2094683A1 (en) | 1994-10-23 |
BR9306067A (pt) | 1998-01-13 |
RU2125873C1 (ru) | 1999-02-10 |
EP0630239A4 (en) | 1995-01-18 |
AU7033496A (en) | 1996-12-19 |
NZ251138A (en) | 1997-06-24 |
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