HUT67583A - Process for producing metal-complexes of n-(beta-hydroxyalkyl)-tri-n-(carboxyalkyl)-1,4,7,10-tetraazacyclododecane and n-(beta-hydroxyalkyl)-tri-n-(carboxyalkyl)-1,4,8,11-tetraazacyclotetradecane derivatives - Google Patents

Process for producing metal-complexes of n-(beta-hydroxyalkyl)-tri-n-(carboxyalkyl)-1,4,7,10-tetraazacyclododecane and n-(beta-hydroxyalkyl)-tri-n-(carboxyalkyl)-1,4,8,11-tetraazacyclotetradecane derivatives

Info

Publication number
HUT67583A
HUT67583A HU9303153A HU9303153A HUT67583A HU T67583 A HUT67583 A HU T67583A HU 9303153 A HU9303153 A HU 9303153A HU 9303153 A HU9303153 A HU 9303153A HU T67583 A HUT67583 A HU T67583A
Authority
HU
Hungary
Prior art keywords
carboxyalkyl
hydroxyalkyl
tri
beta
complexes
Prior art date
Application number
HU9303153A
Other languages
English (en)
Other versions
HU214014B (en
Inventor
Johannes Platzek
Heinz Gries
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of HUT67583A publication Critical patent/HUT67583A/hu
Publication of HU214014B publication Critical patent/HU214014B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU9303153A 1992-11-06 1993-11-05 Process for producing metal-complexes of n-(beta-hydroxyalkyl)-n',n",n"'-tris-(carboxyalkyl)-1,4,7,10-tetraaza-cyclododecane and n-(beta-hydroxyalkyl)-n',n",n"'-tris(carboxyalkyl)-1,4,8,11-tetraaza-cyclotetradecane derivatives HU214014B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4237943A DE4237943C2 (de) 1992-11-06 1992-11-06 Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate

Publications (2)

Publication Number Publication Date
HUT67583A true HUT67583A (en) 1995-04-28
HU214014B HU214014B (en) 1997-12-29

Family

ID=6472539

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9303153A HU214014B (en) 1992-11-06 1993-11-05 Process for producing metal-complexes of n-(beta-hydroxyalkyl)-n',n",n"'-tris-(carboxyalkyl)-1,4,7,10-tetraaza-cyclododecane and n-(beta-hydroxyalkyl)-n',n",n"'-tris(carboxyalkyl)-1,4,8,11-tetraaza-cyclotetradecane derivatives

Country Status (13)

Country Link
EP (1) EP0596586B1 (hu)
JP (1) JP3727359B2 (hu)
AT (1) ATE148110T1 (hu)
CA (1) CA2102461C (hu)
CZ (1) CZ285411B6 (hu)
DE (2) DE4237943C2 (hu)
DK (1) DK0596586T3 (hu)
ES (1) ES2099900T3 (hu)
GR (1) GR3022866T3 (hu)
HU (1) HU214014B (hu)
IL (1) IL107394A (hu)
NO (1) NO302174B1 (hu)
SK (1) SK281285B6 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407435D0 (en) * 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
EP2327395A1 (en) 2009-11-23 2011-06-01 Bracco Imaging S.p.A Process for the preparation of gadobenate dimeglumine complex in a solid form
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
JP6124078B2 (ja) * 2010-08-26 2017-05-10 ツイ，クンユァン 巨大環状脂肪族化合物及びその応用
CN103547573B (zh) 2011-04-21 2016-08-17 拜耳知识产权有限责任公司 高纯度钆布醇的制备
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
BR112019006066A2 (pt) 2016-09-27 2019-06-18 Bayer Pharma AG método para produzir a forma cristalina de modificação a de calcobutrol
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
ES2086445T3 (es) * 1987-07-16 1996-07-01 Nycomed Imaging As Acidos aminocarboxilicos y sus derivados.
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
AU6709390A (en) * 1989-12-22 1991-06-27 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IT1243801B (it) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen

Also Published As

Publication number Publication date
DE4237943A1 (de) 1994-05-11
DE4237943C2 (de) 1997-10-23
EP0596586B1 (de) 1997-01-22
NO302174B1 (no) 1998-02-02
CA2102461A1 (en) 1994-05-07
ATE148110T1 (de) 1997-02-15
IL107394A0 (en) 1994-01-25
GR3022866T3 (en) 1997-06-30
NO934002L (no) 1994-05-09
CZ285411B6 (cs) 1999-08-11
DE59305238D1 (de) 1997-03-06
CZ237493A3 (en) 1994-10-19
JP3727359B2 (ja) 2005-12-14
EP0596586A1 (de) 1994-05-11
HU214014B (en) 1997-12-29
JPH06228115A (ja) 1994-08-16
SK124193A3 (en) 1994-12-07
DK0596586T3 (da) 1997-07-28
ES2099900T3 (es) 1997-06-01
IL107394A (en) 1998-06-15
NO934002D0 (no) 1993-11-05
SK281285B6 (sk) 2001-02-12
CA2102461C (en) 2005-01-25

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