HUT53664A - Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient - Google Patents

Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient

Info

Publication number
HUT53664A
HUT53664A HU896606A HU660689A HUT53664A HU T53664 A HUT53664 A HU T53664A HU 896606 A HU896606 A HU 896606A HU 660689 A HU660689 A HU 660689A HU T53664 A HUT53664 A HU T53664A
Authority
HU
Hungary
Prior art keywords
compounds
amino acid
active ingredient
pharmaceutical compositions
acid derivatives
Prior art date
Application number
HU896606A
Other languages
English (en)
Other versions
HU205369B (en
HU896606D0 (en
Inventor
Wolfgang Rueger
Hansjoerg Urbach
Dieter Ruppert
Bernward Schoelkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HU896606D0 publication Critical patent/HU896606D0/hu
Publication of HUT53664A publication Critical patent/HUT53664A/hu
Publication of HU205369B publication Critical patent/HU205369B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
HU896606A 1988-12-14 1989-12-14 Process for producing enzyme inhibiting amino acid and dipeptide derivatives and pharmaceutical compositions comprising such compounds as active ingredient HU205369B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3842067A DE3842067A1 (de) 1988-12-14 1988-12-14 Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Publications (3)

Publication Number Publication Date
HU896606D0 HU896606D0 (en) 1990-02-28
HUT53664A true HUT53664A (en) 1990-11-28
HU205369B HU205369B (en) 1992-04-28

Family

ID=6369139

Family Applications (1)

Application Number Title Priority Date Filing Date
HU896606A HU205369B (en) 1988-12-14 1989-12-14 Process for producing enzyme inhibiting amino acid and dipeptide derivatives and pharmaceutical compositions comprising such compounds as active ingredient

Country Status (16)

Country Link
US (1) US5185324A (hu)
EP (1) EP0373549B1 (hu)
JP (1) JPH02204475A (hu)
KR (1) KR900009691A (hu)
AT (1) ATE93863T1 (hu)
AU (1) AU632519B2 (hu)
CA (1) CA2005422A1 (hu)
DE (2) DE3842067A1 (hu)
DK (1) DK629889A (hu)
ES (1) ES2059688T3 (hu)
FI (1) FI895921A0 (hu)
HU (1) HU205369B (hu)
IL (1) IL92660A0 (hu)
NO (1) NO895002L (hu)
PT (1) PT92558B (hu)
ZA (1) ZA899507B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6313094B1 (en) 1990-12-11 2001-11-06 Japan Energy Corporation β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
RU2126794C1 (ru) * 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
NZ332315A (en) * 1996-04-17 2000-03-27 Centaur Pharmaceuticals Inc Nitrone free radical trapping compounds and their use in the treatment of dementia associated with aids virus (HIV-1) infection
FR3012451B1 (fr) * 2013-10-25 2016-11-11 Michelin & Cie Compose 1,3-dipolaire portant une fonction imidazole
FR3012460B1 (fr) 2013-10-25 2015-12-11 Michelin & Cie Composition de caoutchouc comprenant un elastomere dienique portant des fonctions imidazole reparties de facon aleatoire le long de la chaine
FR3012458B1 (fr) 2013-10-25 2015-10-30 Michelin & Cie Composition de caoutchouc comprenant un additif compose 1,3-dipolaire portant une fonction imidazole
WO2021220231A1 (en) 2020-05-01 2021-11-04 Pi Industries Ltd. Composition of propineb and metominostrobin
EP4079748A1 (en) * 2021-04-23 2022-10-26 Insusense ApS Modulators of sortilin activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63503380A (ja) * 1986-01-16 1988-12-08 アボット・ラボラトリーズ ペプチド類似体
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate

Also Published As

Publication number Publication date
US5185324A (en) 1993-02-09
ATE93863T1 (de) 1993-09-15
HU205369B (en) 1992-04-28
ES2059688T3 (es) 1994-11-16
NO895002L (no) 1990-06-15
JPH02204475A (ja) 1990-08-14
CA2005422A1 (en) 1990-06-14
DE58905462D1 (de) 1993-10-07
NO895002D0 (no) 1989-12-13
AU4611589A (en) 1990-06-28
DE3842067A1 (de) 1990-06-21
KR900009691A (ko) 1990-07-05
FI895921A0 (fi) 1989-12-12
EP0373549B1 (de) 1993-09-01
ZA899507B (en) 1990-08-29
HU896606D0 (en) 1990-02-28
EP0373549A2 (de) 1990-06-20
DK629889D0 (da) 1989-12-13
PT92558A (pt) 1990-06-29
EP0373549A3 (de) 1991-08-21
IL92660A0 (en) 1990-08-31
PT92558B (pt) 1995-08-09
AU632519B2 (en) 1993-01-07
DK629889A (da) 1990-06-15

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee