HUT44503A - Process for producing dihydropyridine derivatives of antihypertensive activity and pharmaceutical compositions containing them - Google Patents

Process for producing dihydropyridine derivatives of antihypertensive activity and pharmaceutical compositions containing them

Info

Publication number
HUT44503A
HUT44503A HU872680A HU268087A HUT44503A HU T44503 A HUT44503 A HU T44503A HU 872680 A HU872680 A HU 872680A HU 268087 A HU268087 A HU 268087A HU T44503 A HUT44503 A HU T44503A
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
compositions containing
antihypertensive activity
dihydropyridine derivatives
producing
Prior art date
Application number
HU872680A
Other languages
English (en)
Hungarian (hu)
Inventor
Gilles Genain
Original Assignee
Syntex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Lab filed Critical Syntex Lab
Publication of HUT44503A publication Critical patent/HUT44503A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU872680A 1986-06-13 1987-06-12 Process for producing dihydropyridine derivatives of antihypertensive activity and pharmaceutical compositions containing them HUT44503A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/874,264 US4761420A (en) 1986-06-13 1986-06-13 Antihypertensive dihydropyridine derivatives

Publications (1)

Publication Number Publication Date
HUT44503A true HUT44503A (en) 1988-03-28

Family

ID=25363361

Family Applications (1)

Application Number Title Priority Date Filing Date
HU872680A HUT44503A (en) 1986-06-13 1987-06-12 Process for producing dihydropyridine derivatives of antihypertensive activity and pharmaceutical compositions containing them

Country Status (13)

Country Link
US (1) US4761420A (fi)
EP (1) EP0249245A3 (fi)
JP (1) JPS632977A (fi)
KR (1) KR880000394A (fi)
AU (1) AU7416087A (fi)
DK (1) DK300887A (fi)
FI (1) FI872634A (fi)
HU (1) HUT44503A (fi)
IL (1) IL82860A0 (fi)
NO (1) NO872463L (fi)
PL (1) PL266231A1 (fi)
PT (1) PT85075A (fi)
ZA (1) ZA874257B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
JPH01279862A (ja) * 1987-12-11 1989-11-10 Lab Syntex Sa 神経保護化合物
DE3801717C1 (fi) * 1988-01-21 1989-05-24 Alter S.A., Madrid, Es
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
DE4041814A1 (de) * 1990-12-24 1992-07-02 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von dihydrophyridincarbonsaeuren
US5135936A (en) * 1991-03-05 1992-08-04 Marion Merrell Dow Inc. Isomers of 1-azabicyclo[2.2.2]oct-3-yl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinediacarboxylic and their use as calcium antagonists
DE4342193A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester
EP0824115A1 (en) * 1996-08-13 1998-02-18 Bp Chemicals S.N.C. Polymerisation process
US9416901B2 (en) 2007-07-20 2016-08-16 Scorched Ice Inc. Ice skate blade and blade heating arrangement
US7866673B2 (en) * 2007-07-20 2011-01-11 Therma Blade Hockey Corp. Heating arrangement for ice skate blades
US7866674B2 (en) * 2007-09-07 2011-01-11 Thermablade Hockey Corp. Electrically heated ice skates
CN102655095B (zh) 2011-06-01 2014-10-15 京东方科技集团股份有限公司 薄膜晶体管及阵列基板的制造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
EP0164247B1 (en) * 1984-06-07 1989-01-11 Pfizer Limited Dihydropyridines
JPS6143165A (ja) * 1984-08-07 1986-03-01 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体の製造法
US4595690A (en) * 1985-02-11 1986-06-17 Syntex (U.S.A.) Inc. Antihypertensive dihydropyridine derivatives

Also Published As

Publication number Publication date
AU7416087A (en) 1987-12-17
NO872463L (no) 1987-12-14
EP0249245A3 (en) 1988-08-10
ZA874257B (en) 1989-01-25
NO872463D0 (no) 1987-06-12
FI872634A (fi) 1987-12-14
PT85075A (en) 1987-07-01
PL266231A1 (en) 1988-09-01
US4761420A (en) 1988-08-02
KR880000394A (ko) 1988-03-25
FI872634A0 (fi) 1987-06-12
DK300887A (da) 1987-12-14
IL82860A0 (en) 1987-12-20
EP0249245A2 (en) 1987-12-16
DK300887D0 (da) 1987-06-12
JPS632977A (ja) 1988-01-07

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