HUP9904029A2 - 2-(3,4-Dimetoxi-cinnamoil)-amino-benzoesav felhasználása resztenózis kezelésére vagy megelőzésére szolgáló gyógyszer előállítására - Google Patents
2-(3,4-Dimetoxi-cinnamoil)-amino-benzoesav felhasználása resztenózis kezelésére vagy megelőzésére szolgáló gyógyszer előállításáraInfo
- Publication number
- HUP9904029A2 HUP9904029A2 HU9904029A HUP9904029A HUP9904029A2 HU P9904029 A2 HUP9904029 A2 HU P9904029A2 HU 9904029 A HU9904029 A HU 9904029A HU P9904029 A HUP9904029 A HU P9904029A HU P9904029 A2 HUP9904029 A2 HU P9904029A2
- Authority
- HU
- Hungary
- Prior art keywords
- patient
- treatment
- dimethoxycinnamoyl
- restenosis
- medicament
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- NZHGWWWHIYHZNX-UHFFFAOYSA-N 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C=CC(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 208000037803 restenosis Diseases 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 230000029142 excretion Effects 0.000 abstract 1
- 210000004209 hair Anatomy 0.000 abstract 1
- 210000003780 hair follicle Anatomy 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 239000004575 stone Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány a 2-(3,4-dimetőxi-cinnamőil)-aminő-benzőesav gyógyászatihatóanyagként való felhasználásával főglalkőzik a kőszőrúéren végzettbeavatkőzással kapcsőlatős resztenózis megakadályőzására, mely abbóláll, hőgy a betegnek Tranilastőt vagy gyóyágyszati szempőntbólalkalmazható sóját őlyan dózisban adják be, mely a Tranilast plazmábanlévő kőncentrációjának 100 mM körüli értéken való fenntartásáhőzszükséges, őlyan kezelési időtartamőt alkalmazva, mely megakadályőzzaaz ér simaizőmsejtjeinek felesleges felszapőrődását a kőszőrúérenvégzett beavatkőzást követően. Ez az időtartam a beavatkőzást követőenrövidebb, mint 3 hónap. Egy adőtt kezelésnél az alkalmazőtt dózisnagysága és a kezelés időtartama őlyan tényezőktől függ, mint a betegtesttömege, életkőra és neme, a kezelendő állapőt súlyőssága, a betegalkata, mely befőlyásőlja a felszívódás mértékét és sebességét, ahatóanyag előszlását, metabőlizműsát, kiválasztását, stb. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/774,418 US6019104A (en) | 1996-12-30 | 1996-12-30 | Method for the treatment or prevention of restenosis associated with coronary intervention |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9904029A2 true HUP9904029A2 (hu) | 2000-05-28 |
| HUP9904029A3 HUP9904029A3 (en) | 2000-11-28 |
Family
ID=25101171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904029A HUP9904029A3 (en) | 1996-12-30 | 1997-12-19 | Use of 2-(3,4-dimethoxycinnamoyl)aminobenzoic acid for the manufacture of a medicament for the treatment or prevention of restenosis |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6019104A (hu) |
| EP (1) | EP0891185A2 (hu) |
| KR (1) | KR19990087396A (hu) |
| CN (1) | CN1220599A (hu) |
| AR (1) | AR009446A1 (hu) |
| AU (1) | AU7854198A (hu) |
| BR (1) | BR9707877A (hu) |
| CA (1) | CA2247306A1 (hu) |
| CZ (1) | CZ251198A3 (hu) |
| EA (1) | EA001931B1 (hu) |
| HU (1) | HUP9904029A3 (hu) |
| ID (1) | ID20165A (hu) |
| IL (1) | IL125660A0 (hu) |
| NO (1) | NO983947D0 (hu) |
| NZ (1) | NZ331338A (hu) |
| PE (1) | PE27399A1 (hu) |
| TR (1) | TR199801698T1 (hu) |
| WO (1) | WO1998029104A2 (hu) |
| ZA (1) | ZA9711719B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4583597B2 (ja) * | 1998-05-05 | 2010-11-17 | ボストン サイエンティフィック リミテッド | 末端が滑らかなステント |
| BR0007901A (pt) * | 1999-02-03 | 2001-10-30 | Smithkline Beecham Corp | Método para a preservação ou redução deeventos cardiovasculares associados comintervenção coronária |
| KR20010101934A (ko) * | 1999-02-03 | 2001-11-15 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 관상혈관 시술과 관련된 심혈관 사건의 예방 및 감소 방법 |
| AU2001243248A1 (en) * | 2000-02-23 | 2001-09-03 | Smith Kline Beecham Corporation | Method for the prevention or reduction of vascular access dysfunction |
| US20050106230A1 (en) * | 2003-11-17 | 2005-05-19 | Young Janel E. | Drug-enhanced adhesion prevention |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4070484A (en) * | 1973-01-18 | 1978-01-24 | Kissei Pharmaceutical Co., Ltd. | Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same |
| JPS5640710B2 (hu) * | 1973-01-18 | 1981-09-22 | ||
| US4337270A (en) * | 1980-05-21 | 1982-06-29 | Hisamitsu Pharmaceutical Co., Inc. | Novel anthranilic acid derivatives |
| JP2617407B2 (ja) * | 1992-09-14 | 1997-06-04 | キッセイ薬品工業株式会社 | 血管内膜細胞過剰増殖疾患の予防および治療剤 |
-
1996
- 1996-12-30 US US08/774,418 patent/US6019104A/en not_active Expired - Fee Related
-
1997
- 1997-12-19 CZ CZ982511A patent/CZ251198A3/cs unknown
- 1997-12-19 CA CA002247306A patent/CA2247306A1/en not_active Abandoned
- 1997-12-19 TR TR1998/01698T patent/TR199801698T1/xx unknown
- 1997-12-19 WO PCT/JP1997/004698 patent/WO1998029104A2/en not_active Application Discontinuation
- 1997-12-19 IL IL12566097A patent/IL125660A0/xx unknown
- 1997-12-19 ID IDW980073D patent/ID20165A/id unknown
- 1997-12-19 BR BR9707877A patent/BR9707877A/pt not_active Application Discontinuation
- 1997-12-19 CN CN97192618A patent/CN1220599A/zh active Pending
- 1997-12-19 AU AU78541/98A patent/AU7854198A/en not_active Abandoned
- 1997-12-19 EP EP97949158A patent/EP0891185A2/en not_active Withdrawn
- 1997-12-19 KR KR1019980706812A patent/KR19990087396A/ko not_active Application Discontinuation
- 1997-12-19 EA EA199800781A patent/EA001931B1/ru not_active IP Right Cessation
- 1997-12-19 NZ NZ331338A patent/NZ331338A/xx unknown
- 1997-12-19 HU HU9904029A patent/HUP9904029A3/hu unknown
- 1997-12-29 AR ARP970106203A patent/AR009446A1/es not_active Application Discontinuation
- 1997-12-29 PE PE1997001173A patent/PE27399A1/es not_active Application Discontinuation
- 1997-12-30 ZA ZA9711719A patent/ZA9711719B/xx unknown
-
1998
- 1998-08-27 NO NO983947A patent/NO983947D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9711719B (en) | 1998-06-25 |
| IL125660A0 (en) | 1999-04-11 |
| NO983947D0 (no) | 1998-08-27 |
| NZ331338A (en) | 2000-12-22 |
| US6019104A (en) | 2000-02-01 |
| EA001931B1 (ru) | 2001-10-22 |
| AU7854198A (en) | 1998-07-31 |
| PE27399A1 (es) | 1999-03-31 |
| AR009446A1 (es) | 2000-04-12 |
| WO1998029104A2 (en) | 1998-07-09 |
| CN1220599A (zh) | 1999-06-23 |
| CZ251198A3 (cs) | 1999-08-11 |
| HUP9904029A3 (en) | 2000-11-28 |
| BR9707877A (pt) | 1999-07-27 |
| KR19990087396A (ko) | 1999-12-27 |
| TR199801698T1 (xx) | 1999-03-22 |
| EA199800781A1 (ru) | 1999-12-29 |
| CA2247306A1 (en) | 1998-07-09 |
| ID20165A (id) | 1998-10-15 |
| EP0891185A2 (en) | 1999-01-20 |
| WO1998029104A3 (en) | 1998-10-01 |
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