HUP9901966A2 - Kinolonkarbonsavszármazékok vagy sóik - Google Patents

Kinolonkarbonsavszármazékok vagy sóik

Info

Publication number
HUP9901966A2
HUP9901966A2 HU9901966A HUP9901966A HUP9901966A2 HU P9901966 A2 HUP9901966 A2 HU P9901966A2 HU 9901966 A HU9901966 A HU 9901966A HU P9901966 A HUP9901966 A HU P9901966A HU P9901966 A2 HUP9901966 A2 HU P9901966A2
Authority
HU
Hungary
Prior art keywords
hydrogen
group
protected
optionally substituted
halogen atom
Prior art date
Application number
HU9901966A
Other languages
English (en)
Inventor
Kazuya Hayashi
Hirokazu Narita
Masahiro Takahata
Yozo Todo
Yasuo Watanabe
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of HUP9901966A2 publication Critical patent/HUP9901966A2/hu
Publication of HUP9901966A3 publication Critical patent/HUP9901966A3/hu
Publication of HU228567B1 publication Critical patent/HU228567B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány tárgyát az (1) általánős képletű kinőlőnkarbőnsav-származékők vagy sói képezik, ahől R1 karbőxi védőcsőpőrt vagy hidrőgénatőm; R2-R6 hidrőgén- vagy halőgénatőm, adőtt esetben szűbsztitűált alkil-,alkenil-, alkőxi-, ciklőalkil-, aril-, aralkil- vagy heterőciklűsőscsőpőrt, védett vagy nem védett hidrőxi-, aminő- vagy iminőcsőpőrt,nitrő-, cianő-, acil-, alkilidén- vagy alkil-tiő-csőpőrt. A találmányszerinti előnyös vegyületekben R2 adőtt esetben szűbsztitűáltciklőalkilcsőpőrt; R3 hidrőgén- vagy halőgénatőm, adőtt esetbenszűbsztitűált alkil- vagy alkőxicsőpőrt és védett vagy nem védetthidrőxi- vagy aminőcsőpőrt közül kiválasztőtt legalább egyszűbsztitűens; R4 hidrőgénatőm vagy adőtt esetben szűbsztitűáltalkilcsőpőrt; R5 és R6 egyaránt hidrőgénatőm; A C-Y általánős képletűcsőpőrt; és Y halőgénatőm vagy alkil- vagy alkőxicsőpőrt, amely űtóbbiegy vagy több halőgénatőmmal szűbsztitűált lehet, vagy védett vagy nemvédett hidrőxicsőpőrt. A találmány szerinti vegyületek erősantibakteriális hatást műtatnak Gram-pőzitív és Gram-negatívbaktériűmőkkal, különösen pedig a MRSA-baktériűmtörzsekkel szemben. ŕ
HU9901966A 1996-02-09 1997-02-07 Quinolonecarboxylic acid derivatives or salts thereof HU228567B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4793696 1996-02-09
PCT/JP1997/000317 WO1997029102A1 (fr) 1996-02-09 1997-02-07 Derives de l'acide quinolonecarboxylique et leurs sels

Publications (3)

Publication Number Publication Date
HUP9901966A2 true HUP9901966A2 (hu) 1999-09-28
HUP9901966A3 HUP9901966A3 (en) 2002-01-28
HU228567B1 HU228567B1 (en) 2013-04-29

Family

ID=12789268

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901966A HU228567B1 (en) 1996-02-09 1997-02-07 Quinolonecarboxylic acid derivatives or salts thereof

Country Status (18)

Country Link
US (1) US6025370A (hu)
EP (1) EP0882725B1 (hu)
KR (1) KR100276477B1 (hu)
CN (2) CN1100053C (hu)
AT (1) ATE229950T1 (hu)
AU (1) AU711914B2 (hu)
CA (1) CA2242242C (hu)
DE (1) DE69717970T2 (hu)
DK (1) DK0882725T3 (hu)
ES (1) ES2188890T3 (hu)
HK (1) HK1039118B (hu)
HU (1) HU228567B1 (hu)
IL (1) IL124944A (hu)
NO (1) NO316666B1 (hu)
NZ (1) NZ330775A (hu)
PT (1) PT882725E (hu)
WO (1) WO1997029102A1 (hu)
ZA (1) ZA971023B (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286420B6 (sk) 1997-09-15 2008-09-05 The Procter & Gamble Company Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
TWI242012B (en) * 1997-10-27 2005-10-21 Toyama Chemical Co Ltd (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1h-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate, its monohydrate and anti-bacterially pharmaceutical composition comprising the same as active ingredient
DE69933660T2 (de) * 1998-04-06 2007-08-23 Toyama Chemical Co. Ltd. Chinoloncarbonsäurederivate oder deren salze
JP4499846B2 (ja) * 1998-05-07 2010-07-07 富山化学工業株式会社 ７−イソインドリン−キノロンカルボン酸誘導体の製造法並びにイソインドリン−５−ボロン酸誘導体の製造法
JP4549461B2 (ja) * 1998-08-31 2010-09-22 富山化学工業株式会社 ７−ブロモ−キノロンカルボン酸誘導体の製造法
JP2000229946A (ja) * 1998-12-10 2000-08-22 Toyama Chem Co Ltd キノロンカルボン酸の製造法およびその中間体
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
MXPA04008720A (es) * 2002-03-12 2004-12-06 Squibb Bristol Myers Co Suspension oral de sabor agradable y metodo.
JP4616770B2 (ja) * 2003-06-19 2011-01-19 第一三共株式会社 選択的なアミノ置換基導入法
KR100981351B1 (ko) * 2003-10-29 2010-09-10 주식회사 엘지생명과학 7-클로로-1-사이클로프로필-6-플루오로-4-옥소-1,4-디하이드로-1,8-나프티리딘-3-카복실산의 제조방법
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
EP1873134B1 (en) * 2005-03-03 2013-02-13 JNC Corporation Chlorofluorobenzene liquid crystalline compound, liquid crystal composition, and liquid crystal display element
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
US7528264B2 (en) 2006-03-28 2009-05-05 The Procter & Gamble Company Hydride reduction process for preparing quinolone intermediates
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101298418B (zh) * 2008-06-13 2010-12-15 江苏康鹏农化有限公司 3-氧代-3-(2,4-二卤代-3-二氟甲氧基苯基)丙酸乙酯的制备方法
CN102212056A (zh) * 2010-04-09 2011-10-12 山东轩竹医药科技有限公司 新的双环喹诺酮类化合物
WO2013121439A2 (en) * 2012-02-15 2013-08-22 Glenmark Generics Limited Process for garenoxacin mesylate
GB201516614D0 (en) * 2015-09-18 2015-11-04 Redx Pharma Plc Antibacterial compounds
CN105837555B (zh) * 2016-03-31 2019-01-25 南京华威医药科技集团有限公司 加雷沙星及其中间体制备方法
CN111620901B (zh) * 2020-06-08 2023-03-21 蚌埠医学院第二附属医院 一种含硅氧烷基的氟喹诺酮化合物、其制备方法及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6199835A (ja) * 1984-10-22 1986-05-17 Shimadzu Corp 振動試験機の波形補正装置
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
RU2049777C1 (ru) * 1989-08-16 1995-12-10 Пфайзер Инк. Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
JPH07300472A (ja) * 1992-12-28 1995-11-14 Korea Res Inst Chem Technol 新規キノロンカルボン酸誘導体およびその製造方法
JPH06199835A (ja) * 1993-01-08 1994-07-19 Hokuriku Seiyaku Co Ltd ８−ジフルオロメトキシキノリン−３−カルボン酸誘導体
DE4301246A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
JPH0848629A (ja) * 1994-08-08 1996-02-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびそれを有効成分とする抗ピロリ菌剤
DK0775702T3 (da) * 1994-08-12 2003-08-18 Toyama Chemical Co Ltd Hidtil ukendte quinolon- eller naphthylidoncarboxylsyrederivater eller salt deraf

Also Published As

Publication number Publication date
DE69717970T2 (de) 2003-04-30
WO1997029102A1 (fr) 1997-08-14
HK1039118B (zh) 2009-01-30
KR19990082406A (ko) 1999-11-25
DE69717970D1 (de) 2003-01-30
PT882725E (pt) 2003-04-30
ATE229950T1 (de) 2003-01-15
HK1039118A1 (en) 2002-04-12
US6025370A (en) 2000-02-15
DK0882725T3 (da) 2003-01-13
HU228567B1 (en) 2013-04-29
IL124944A (en) 2003-06-24
CA2242242C (en) 2001-08-07
AU1670197A (en) 1997-08-28
HUP9901966A3 (en) 2002-01-28
IL124944A0 (en) 1999-01-26
CN1210533A (zh) 1999-03-10
KR100276477B1 (ko) 2000-12-15
NZ330775A (en) 1999-08-30
EP0882725B1 (en) 2002-12-18
CA2242242A1 (en) 1997-08-14
CN1100053C (zh) 2003-01-29
AU711914B2 (en) 1999-10-21
EP0882725A1 (en) 1998-12-09
NO983625D0 (no) 1998-08-07
NO316666B1 (no) 2004-03-29
NO983625L (no) 1998-08-07
CN100395244C (zh) 2008-06-18
EP0882725A4 (en) 1999-05-06
ES2188890T3 (es) 2003-07-01
ZA971023B (en) 1997-09-25
CN1314355A (zh) 2001-09-26

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