HUP9901037A2 - Piperazinszármazékok, előállításuk és alkalmazásuk, ezeket a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Piperazinszármazékok, előállításuk és alkalmazásuk, ezeket a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9901037A2
HUP9901037A2 HU9901037A HUP9901037A HUP9901037A2 HU P9901037 A2 HUP9901037 A2 HU P9901037A2 HU 9901037 A HU9901037 A HU 9901037A HU P9901037 A HUP9901037 A HU P9901037A HU P9901037 A2 HUP9901037 A2 HU P9901037A2
Authority
HU
Hungary
Prior art keywords
alkyl
carbonyl
amino
substituted
pyridyl
Prior art date
Application number
HU9901037A
Other languages
English (en)
Inventor
Norihiro Igari
Nobukiyo Konishi
Takashi Manabe
Hiroshi Matsuda
Masaaki Matsuo
Shinji Shigenaga
Kazuhiko Take
Tadashi Terasaka
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9525841.4A external-priority patent/GB9525841D0/en
Priority claimed from AUPN9891A external-priority patent/AUPN989196A0/en
Priority claimed from AUPO2683A external-priority patent/AUPO268396A0/en
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of HUP9901037A2 publication Critical patent/HUP9901037A2/hu
Publication of HUP9901037A3 publication Critical patent/HUP9901037A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A cím szerinti vegyületek (I) általánős képletében Y jelentésevegyértékkötés vagy rövid szénláncú alkiléncsőpőrt, R1 jelentése adőttesetben szűbsztitűált arilcsőpőrt, R2 jelentése aril- vagyindőlilcsőpőrt, ahől mindkettő adőtt esetben szűbsztitűálva van, R3jelentése hidrőgénatőm vagy rövid szénláncú alkilcsőpőrt, R4 jelentéseklór-alkenil-, klór-alkinil-, piridil-alkil-aminő-alkil-, piridil-alkil-aminő-alkenil-, N-alkil-N-(piridil-alkil)-aminő-alkil-,triazőlil-aminő-alkil-, alkőxi-alkil-aminő-alkil-, bisz(alkőxi-alkil)-aminő-alkil-, N-alkil-N-(alkőxi-alkil)-aminő-alkil-, hidrőxi-alkil-,alkil-szűlfőnil-őxi-alkil-, adőtt esetben szűbsztitűált fenil-alkil-,alkőxi-fenil-alkil-karbőnil-, alkanőil-benzőil-, adőtt esetben szűbsz-titűált benzőil-alkil-, 3-[2-(4-flűőr-fenil-1,3-diőxőlán-2-il]-prőpil-, adőtt esetben szűbsztitűált piperazinil-karbőnil-, tienil-karbőnil-alkil-, tiőmőrfőlinil-karbőnil-alkil-, 3-aza-biciklő-[3.2.2]nőn-3-il-karbőnil-alkil-, piridil-alkil-, tetrahidrőpiridil-alkil-, tetrahidrőizőkinőlil-alkil-, imidazőlil-alkil-, pirőzőlil-alkil-, tetrahidrőtienő[3,2-c]piridinil-alkil-csőpőrt vagy agyűrűrészben adőtt esetben szűbsztitűált telített heterőciklűsőscsőpőrttal helyettesített, vagy telített heterőciklűsős csőpőrttalszűbsztitűált aminőcsőpőrttal helyettesített alkil-, alkenil- vagyalkinilcsőpőrt. A találmány tárgykörébe tartőznak a fenti vegyületekgyógyászatilag alkalmazható sói is. ŕ
HU9901037A 1995-12-18 1996-12-12 Piperazine derivatives,preparation and use thereof, pharmaceutical compositions containing these compounds HUP9901037A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9525841.4A GB9525841D0 (en) 1995-12-18 1995-12-18 Piperazine derivatives
AUPN9891A AUPN989196A0 (en) 1996-05-16 1996-05-16 Piperazine derivatives
AUPO2683A AUPO268396A0 (en) 1996-09-30 1996-09-30 Piperazine derivatives

Publications (2)

Publication Number Publication Date
HUP9901037A2 true HUP9901037A2 (hu) 1999-07-28
HUP9901037A3 HUP9901037A3 (en) 2001-11-28

Family

ID=27157927

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901037A HUP9901037A3 (en) 1995-12-18 1996-12-12 Piperazine derivatives,preparation and use thereof, pharmaceutical compositions containing these compounds

Country Status (13)

Country Link
US (2) US6087357A (hu)
EP (1) EP0873320B1 (hu)
JP (1) JP2000502100A (hu)
KR (1) KR20000064415A (hu)
CN (1) CN1209125A (hu)
AT (1) ATE219064T1 (hu)
AU (1) AU714931B2 (hu)
CA (1) CA2240835A1 (hu)
DE (1) DE69621831T2 (hu)
ES (1) ES2175161T3 (hu)
HU (1) HUP9901037A3 (hu)
IL (1) IL124674A0 (hu)
WO (1) WO1997022597A1 (hu)

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DE69735811T2 (de) * 1996-10-30 2006-12-28 Schering Corp. Piperazinoderivate als neurokinin-antagonisten
US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
US5783579A (en) * 1996-12-20 1998-07-21 Schering Corporation Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists
AUPO735997A0 (en) * 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
AU743723B2 (en) * 1997-06-17 2002-01-31 Astellas Pharma Inc. Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists
EP1140924B1 (en) * 1998-12-14 2006-03-22 Astellas Pharma Inc. Piperazine derivatives
AU2056800A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Heterocyclic piperidines as modulators of chemokine receptor activity
CA2347769A1 (en) 1998-12-18 2000-06-22 Dean A. Wacker 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
DE69926919D1 (de) 1998-12-18 2005-09-29 Bristol Myers Squibb Pharma Co N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU3126700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
WO2000035452A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6897234B2 (en) 1999-12-17 2005-05-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
TW591025B (en) * 2000-06-13 2004-06-11 Fujisawa Pharmaceutical Co Production of the piperazine derivative
CA2413245A1 (en) 2000-06-30 2002-01-10 Bristol-Myers Squibb Pharma Company N-ureidoheterocycloaklyl-piperidines as modulators of chemokine receptor activity
DE10036818A1 (de) 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
UA75425C2 (en) * 2001-07-09 2006-04-17 Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
EP1425029A4 (en) * 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
UA77515C2 (en) 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
CA2589483C (en) 2004-12-03 2013-10-29 Schering Corporation Substituted piperazines as cb1 antagonists
AU2006275568A1 (en) * 2005-08-02 2007-02-08 Neurogen Corporation Dipiperazinyl ketones and related analogues
CA2637565A1 (en) 2006-01-18 2007-07-26 Schering Corporation Cannibinoid receptor modulators
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
EP2117538A1 (en) 2007-01-24 2009-11-18 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
RU2010102478A (ru) 2007-06-28 2011-08-10 Интэрвэт Интэрнэшнл Б.Ф. (NL) Замещенные пиперазины как антагонисты св1
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Also Published As

Publication number Publication date
AU714931B2 (en) 2000-01-13
KR20000064415A (ko) 2000-11-06
US6087357A (en) 2000-07-11
CN1209125A (zh) 1999-02-24
ES2175161T3 (es) 2002-11-16
WO1997022597A1 (en) 1997-06-26
JP2000502100A (ja) 2000-02-22
US20020010182A1 (en) 2002-01-24
CA2240835A1 (en) 1997-06-26
IL124674A0 (en) 1998-12-06
AU1110697A (en) 1997-07-14
DE69621831D1 (de) 2002-07-18
HUP9901037A3 (en) 2001-11-28
DE69621831T2 (de) 2003-01-02
EP0873320A1 (en) 1998-10-28
ATE219064T1 (de) 2002-06-15
EP0873320B1 (en) 2002-06-12

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