HUP9900563A2 - Kinolin-2-(1H)-onok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Kinolin-2-(1H)-onok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP9900563A2
HUP9900563A2 HU9900563A HUP9900563A HUP9900563A2 HU P9900563 A2 HUP9900563 A2 HU P9900563A2 HU 9900563 A HU9900563 A HU 9900563A HU P9900563 A HUP9900563 A HU P9900563A HU P9900563 A2 HUP9900563 A2 HU P9900563A2
Authority
HU
Hungary
Prior art keywords
nr6r7
compounds
production
chinoline
ones
Prior art date
Application number
HU9900563A
Other languages
English (en)
Inventor
Karl-August Ackermann
Rudolf Gottschlich
Günter Hölzemann
Joachim Leibrock
Wilfried Rautenberg
Christoph Seyfried
Original Assignee
MERCK Patent Gesellschaft mit beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MERCK Patent Gesellschaft mit beschränkter Haftung filed Critical MERCK Patent Gesellschaft mit beschränkter Haftung
Publication of HUP9900563A2 publication Critical patent/HUP9900563A2/hu
Publication of HUP9900563A3 publication Critical patent/HUP9900563A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya (I) általánős képletű kinőlin-2-(1H)-őn-származékőkvagy sói és szőlvátjai -, ahől R1, R2 és R3 egymástól függetlenüllehet hidrőgénatőm vagy halőgénatőm, A vagy OA, R4 jelentése H, -(CH2)m-NR6R7, R5 jelentése H, -(CH2)n-NR6R7, R6 jelentésehidrőgénatőm, A vagy R7-tel együtt -(CH2)4-, illetve -(CH2)5-, R7jelentése hidrőgénatőm, A vagy -(CH2)m-, amely az azőnős vagyszőmszédős B vagy D gyűrűhöz kötődik, vagy R6-tal együtt -(CH2)4-,illetve -(CH2)5- csőpőrtőt képez, X jelentése -CHR5, -NR5, -O-, -S-, Ajelentése 1-6 szénatőmős alkilcsőpőrt, Hal jelentése flűőr-, klór-,bróm- vagy jódatőm, m értéke 1-3 és n értéke 0-3 közötti egész szám,miközben legalább R4 vagy R5 közül az egyik jelentése -(CH2)m-NR6R7,illetve -(CH2)n-NR6R7. A találmány kiterjed az (I) általánős képletűvegyületek vagy fiziőlógiailag elfőgadható sói alkalmazására is aközpőnti idegrendszer működésének neűrődegeneratív elváltőzásaikezelésére, tővábbá a vegyületeket tartalmazó gyógyszerkészítményekreés a vegyületek előállítására is. ŕ
HU9900563A 1996-01-19 1997-01-10 Chinoline-2-(1h)-ones, their production, pharmaceutical compositions and use HUP9900563A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601782A DE19601782A1 (de) 1996-01-19 1996-01-19 Chinolin-2-(1H)one

Publications (2)

Publication Number Publication Date
HUP9900563A2 true HUP9900563A2 (hu) 1999-06-28
HUP9900563A3 HUP9900563A3 (en) 2000-02-28

Family

ID=7783141

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900563A HUP9900563A3 (en) 1996-01-19 1997-01-10 Chinoline-2-(1h)-ones, their production, pharmaceutical compositions and use

Country Status (18)

Country Link
US (1) US6028080A (hu)
EP (1) EP0885196A1 (hu)
JP (1) JP2000503308A (hu)
KR (1) KR19990077308A (hu)
CN (1) CN1211974A (hu)
AR (1) AR005646A1 (hu)
AU (1) AU716230B2 (hu)
BR (1) BR9707027A (hu)
CA (1) CA2243474C (hu)
CZ (1) CZ224098A3 (hu)
DE (1) DE19601782A1 (hu)
HU (1) HUP9900563A3 (hu)
MX (1) MX9805700A (hu)
NO (1) NO983333L (hu)
PL (1) PL327829A1 (hu)
SK (1) SK93198A3 (hu)
WO (1) WO1997026244A1 (hu)
ZA (1) ZA97364B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02004330A (es) * 1999-11-03 2004-07-30 Albany Molecular Res Inc Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
US7273889B2 (en) * 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
US7625949B2 (en) * 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
EP1940781A1 (en) * 2005-10-19 2008-07-09 F.Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
WO2009102893A2 (en) * 2008-02-14 2009-08-20 Amira Pharmaceuticals, Inc. CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors
JP2011513242A (ja) 2008-02-25 2011-04-28 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体アンタゴニスト
WO2009123241A1 (ja) 2008-03-31 2009-10-08 株式会社レナサイエンス プラスミノーゲンアクチベーターインヒビター－１阻害剤
US8426449B2 (en) * 2008-04-02 2013-04-23 Panmira Pharmaceuticals, Llc Aminoalkylphenyl antagonists of prostaglandin D2 receptors
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
US8785473B2 (en) * 2009-03-31 2014-07-22 Renascience Co., Ltd. Plasminogen activator inhibitor-1 inhibitor
EP2521713A4 (en) 2010-01-06 2013-10-02 Panmira Pharmaceuticals Llc ANTAGONIST OF DP2 AND ITS USES
US10092537B2 (en) 2013-04-15 2018-10-09 Renascience Co., Ltd. Use for PAI-1 inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268378A (en) * 1990-05-31 1993-12-07 Merck Sharp & Dohme, Limited Dioxo-tetrahydroquinoline derivatives
EP0459561B1 (en) * 1990-05-31 1995-09-20 MERCK SHARP & DOHME LTD. Dioxo-tetrahydroquinoline derivatives
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
GB9125515D0 (en) * 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
EP0685466A1 (de) * 1994-06-02 1995-12-06 Ciba-Geigy Ag 3-Heteroaliphatyl- und 3-Hetero-(aryl)aliphatyl-2(1H)-chinolonderivate

Also Published As

Publication number Publication date
JP2000503308A (ja) 2000-03-21
CZ224098A3 (cs) 1998-10-14
AU1311297A (en) 1997-08-11
MX9805700A (es) 1998-11-29
BR9707027A (pt) 1999-07-20
CN1211974A (zh) 1999-03-24
AU716230B2 (en) 2000-02-24
AR005646A1 (es) 1999-07-14
PL327829A1 (en) 1999-01-04
NO983333D0 (no) 1998-07-17
CA2243474C (en) 2009-10-27
DE19601782A1 (de) 1997-07-24
NO983333L (no) 1998-09-18
KR19990077308A (ko) 1999-10-25
US6028080A (en) 2000-02-22
HUP9900563A3 (en) 2000-02-28
ZA97364B (en) 1997-07-22
SK93198A3 (en) 1999-01-11
WO1997026244A1 (de) 1997-07-24
CA2243474A1 (en) 1997-07-24
EP0885196A1 (de) 1998-12-23

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