HUP9900521A2 - Process for preparing solid dosage forms of very low-dose drugs - Google Patents
Process for preparing solid dosage forms of very low-dose drugsInfo
- Publication number
- HUP9900521A2 HUP9900521A2 HU9900521A HUP9900521A HUP9900521A2 HU P9900521 A2 HUP9900521 A2 HU P9900521A2 HU 9900521 A HU9900521 A HU 9900521A HU P9900521 A HUP9900521 A HU P9900521A HU P9900521 A2 HUP9900521 A2 HU P9900521A2
- Authority
- HU
- Hungary
- Prior art keywords
- low
- dosage forms
- solid dosage
- preparing solid
- dose drugs
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229940127021 low-dose drug Drugs 0.000 title 1
- 239000007909 solid dosage form Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N methyl cyanide Natural products CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229920001187 thermosetting polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány egyik tárgya őlyan hatóanyag-főrmálási eljárásravőnatkőzik, amelynek sőrán hőrdőzórészecskéket összekevernek egyhatóanyag vizes őldatával, ahől a teljes keverékre vőnatkőztatva azőldatőt 1-3 tömeg% mennyiségben alkalmazzák. A találmány tővábbitárgyát egy dementia kezelésére és/vagy megelőzésére szőlgáló eljárásképezi, amelynek sőrán a betegnek 0,01 mg/kg- nál kisebb napi dózisban[R-(Z)]-a-(metőxi-iminő)-a-1-aza-3-biciklő[2.2.2]őktil}-acetőnitril-mőnőhidrőklőridőt adnak be. A találmány kiterjed a találmány szerintifőrmálási eljárással főrmált hatóanyagőt tartalmazó, illetve atalálmány szerinti kezelési eljárásban alkalmazőttgyógyszerkészítményekre is. ŕOne of the subjects of the invention is the active ingredient manufacturing process, in which thermosetting particles are mixed with an aqueous solution of a single active substance, from which a curing agent is applied to the entire mixture in an amount of 1-3% by weight. The main subject of the invention is a method for the treatment and/or prevention of dementia, in which the patient is given a daily dose of less than 0.01 mg/kg [R-(Z)]-a-(methoxyimino)-a-1-aza- 3-Cyclo[2.2.2]octyl}acetonitrile hydrogen chloride is administered. The invention also covers medicinal preparations containing active ingredients manufactured by the manufacturing process according to the invention and used in the treatment process according to the invention. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9515624.6A GB9515624D0 (en) | 1995-07-29 | 1995-07-29 | Novel process |
| GBGB9606684.0A GB9606684D0 (en) | 1996-03-29 | 1996-03-29 | Novel process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9900521A2 true HUP9900521A2 (en) | 1999-06-28 |
| HUP9900521A3 HUP9900521A3 (en) | 2001-04-28 |
Family
ID=26307485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900521A HUP9900521A3 (en) | 1995-07-29 | 1996-07-29 | Process for preparing solid dosage forms of very low-dose drugs |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0841902A2 (en) |
| JP (1) | JPH11510493A (en) |
| KR (1) | KR19990035972A (en) |
| CN (1) | CN1196677A (en) |
| AP (1) | AP858A (en) |
| AR (1) | AR004178A1 (en) |
| AU (1) | AU716961B2 (en) |
| BG (1) | BG102266A (en) |
| BR (1) | BR9609804A (en) |
| CA (1) | CA2228048A1 (en) |
| CZ (1) | CZ24798A3 (en) |
| DZ (1) | DZ2077A1 (en) |
| EA (2) | EA000740B1 (en) |
| HU (1) | HUP9900521A3 (en) |
| IL (1) | IL122897A0 (en) |
| MA (1) | MA23953A1 (en) |
| MX (1) | MX9800809A (en) |
| NO (1) | NO980384L (en) |
| NZ (1) | NZ315632A (en) |
| OA (1) | OA10659A (en) |
| PL (1) | PL325242A1 (en) |
| SK (1) | SK11098A3 (en) |
| TR (1) | TR199800156T1 (en) |
| UY (1) | UY24297A1 (en) |
| WO (1) | WO1997004750A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9619074D0 (en) * | 1996-09-12 | 1996-10-23 | Smithkline Beecham Plc | Composition |
| IL138192A0 (en) * | 1998-03-11 | 2001-11-25 | Smithkline Beecham Plc | Controlled release oral dosage forms |
| FR2796840B1 (en) * | 1999-07-26 | 2003-06-20 | Ethypharm Lab Prod Ethiques | LOW-DOSE TABLETS AND METHOD OF PREPARATION |
| KR100899032B1 (en) | 2000-12-14 | 2009-05-21 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | Steroid hormone products comprising a stabilizing agent in non-crystalline form |
| WO2005097076A2 (en) * | 2004-04-09 | 2005-10-20 | Smithkline Beecham Corporation | Low dose pharmaceutical products |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4489026A (en) * | 1982-09-07 | 1984-12-18 | The Upjohn Company | Process for preparing solid unit dosage forms of ultra-low dose drugs |
| JPS5970614A (en) * | 1982-10-14 | 1984-04-21 | Asahi Chem Ind Co Ltd | Wet solid pharmaceutical preparation of very small amount of main drug |
| US4898736A (en) * | 1988-03-09 | 1990-02-06 | Merck & Co., Inc. | Method for tablet preparation |
| ES2219636T3 (en) * | 1989-04-13 | 2004-12-01 | Beecham Group P.L.C. | NEW COMPOUNDS. |
| ZA939565B (en) * | 1993-12-21 | 1994-08-11 | Applied Analytical Ind Inc | Method for preparing low dose pharmaceutical products. |
-
1996
- 1996-07-25 AR ARP960103748A patent/AR004178A1/en not_active Application Discontinuation
- 1996-07-26 UY UY24297A patent/UY24297A1/en not_active IP Right Cessation
- 1996-07-26 MA MA24329A patent/MA23953A1/en unknown
- 1996-07-27 DZ DZ960121A patent/DZ2077A1/en active
- 1996-07-29 NZ NZ315632A patent/NZ315632A/en unknown
- 1996-07-29 CN CN96197054A patent/CN1196677A/en active Pending
- 1996-07-29 AP APAP/P/1998/001170A patent/AP858A/en active
- 1996-07-29 IL IL12289796A patent/IL122897A0/en unknown
- 1996-07-29 BR BR9609804A patent/BR9609804A/en not_active Application Discontinuation
- 1996-07-29 KR KR1019980700633A patent/KR19990035972A/en not_active Application Discontinuation
- 1996-07-29 EA EA199800179A patent/EA000740B1/en not_active IP Right Cessation
- 1996-07-29 JP JP9507243A patent/JPH11510493A/en active Pending
- 1996-07-29 HU HU9900521A patent/HUP9900521A3/en unknown
- 1996-07-29 AU AU67384/96A patent/AU716961B2/en not_active Ceased
- 1996-07-29 PL PL96325242A patent/PL325242A1/en unknown
- 1996-07-29 EA EA199901055A patent/EA199901055A1/en unknown
- 1996-07-29 TR TR1998/00156T patent/TR199800156T1/en unknown
- 1996-07-29 EP EP96927621A patent/EP0841902A2/en not_active Withdrawn
- 1996-07-29 CZ CZ98247A patent/CZ24798A3/en unknown
- 1996-07-29 WO PCT/EP1996/003326 patent/WO1997004750A2/en not_active Application Discontinuation
- 1996-07-29 CA CA002228048A patent/CA2228048A1/en not_active Abandoned
- 1996-07-29 MX MX9800809A patent/MX9800809A/en unknown
- 1996-07-29 SK SK110-98A patent/SK11098A3/en unknown
-
1998
- 1998-01-28 OA OA9800013A patent/OA10659A/en unknown
- 1998-01-28 NO NO980384A patent/NO980384L/en unknown
- 1998-02-20 BG BG102266A patent/BG102266A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO980384D0 (en) | 1998-01-28 |
| MX9800809A (en) | 1998-04-30 |
| CN1196677A (en) | 1998-10-21 |
| NO980384L (en) | 1998-03-26 |
| OA10659A (en) | 2002-09-18 |
| KR19990035972A (en) | 1999-05-25 |
| AU716961B2 (en) | 2000-03-09 |
| MA23953A1 (en) | 1997-04-01 |
| SK11098A3 (en) | 1998-07-08 |
| JPH11510493A (en) | 1999-09-14 |
| CA2228048A1 (en) | 1997-02-13 |
| BG102266A (en) | 1998-10-30 |
| UY24297A1 (en) | 1997-01-23 |
| EA199800179A1 (en) | 1998-10-29 |
| AR004178A1 (en) | 1998-11-04 |
| AP858A (en) | 2000-07-12 |
| BR9609804A (en) | 1999-07-06 |
| WO1997004750A2 (en) | 1997-02-13 |
| AU6738496A (en) | 1997-02-26 |
| EA199901055A1 (en) | 2000-06-26 |
| CZ24798A3 (en) | 1998-06-17 |
| TR199800156T1 (en) | 1998-04-21 |
| EP0841902A2 (en) | 1998-05-20 |
| DZ2077A1 (en) | 2002-07-22 |
| HUP9900521A3 (en) | 2001-04-28 |
| IL122897A0 (en) | 1998-08-16 |
| AP9801170A0 (en) | 1998-01-31 |
| NZ315632A (en) | 1999-11-29 |
| WO1997004750A3 (en) | 1997-03-27 |
| PL325242A1 (en) | 1998-07-06 |
| EA000740B1 (en) | 2000-02-28 |
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