EA199901055A1 - PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF DEMENTIA - Google Patents

PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF DEMENTIA

Info

Publication number
EA199901055A1
EA199901055A1 EA199901055A EA199901055A EA199901055A1 EA 199901055 A1 EA199901055 A1 EA 199901055A1 EA 199901055 A EA199901055 A EA 199901055A EA 199901055 A EA199901055 A EA 199901055A EA 199901055 A1 EA199901055 A1 EA 199901055A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dementia
prevention
treatment
pharmaceutical composition
solution
Prior art date
Application number
EA199901055A
Other languages
Russian (ru)
Inventor
Джеймс Альберт Нэппер
Нил Мортимер
Карен Триона О'Браен
Султан Джеймс Манек
Раджиндер Кумар
Майкл Сидней Джордж Кларк
Джулия Мэри Лоудон
Original Assignee
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Application filed by Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс
Publication of EA199901055A1 publication Critical patent/EA199901055A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Abstract

Способ изготовления лекарственного средства, который включает смешивание частиц носителя с водным раствором лекарственного вещества в количестве 1-3% раствора от общего веса смеси, и способ лечения и/или профилактики деменции, который включает введение пациенту [R-(Z)]-α-(метоксиимино)-α-(1-азабицикло[2.2.2]окт-3-ил)ацетонитрила моногидрохлорида в суточной дозе менее 0,01 мг/кг, а также фармацевтические композиции, используемые в этих способах.Международная заявка была опубликована вместе с отчетом о международном поиске.A method of manufacturing a medicinal product, which includes mixing carrier particles with an aqueous solution of a medicinal substance in the amount of 1-3% solution of the total weight of the mixture, and a method of treating and / or preventing dementia, which includes administering to a patient [R- (Z)] - α- (methoxyimino) -α- (1-azabicyclo [2.2.2] oct-3-yl) acetonitrile monohydrochloride in a daily dose of less than 0.01 mg / kg, as well as pharmaceutical compositions used in these methods. The international application was published together with international search report.

EA199901055A 1995-07-29 1996-07-29 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF DEMENTIA EA199901055A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process
PCT/EP1996/003326 WO1997004750A2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs

Publications (1)

Publication Number Publication Date
EA199901055A1 true EA199901055A1 (en) 2000-06-26

Family

ID=26307485

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199800179A EA000740B1 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs and a pharmaceutical obtained therein
EA199901055A EA199901055A1 (en) 1995-07-29 1996-07-29 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND / OR PREVENTION OF DEMENTIA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA199800179A EA000740B1 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs and a pharmaceutical obtained therein

Country Status (25)

Country Link
EP (1) EP0841902A2 (en)
JP (1) JPH11510493A (en)
KR (1) KR19990035972A (en)
CN (1) CN1196677A (en)
AP (1) AP858A (en)
AR (1) AR004178A1 (en)
AU (1) AU716961B2 (en)
BG (1) BG102266A (en)
BR (1) BR9609804A (en)
CA (1) CA2228048A1 (en)
CZ (1) CZ24798A3 (en)
DZ (1) DZ2077A1 (en)
EA (2) EA000740B1 (en)
HU (1) HUP9900521A3 (en)
IL (1) IL122897A0 (en)
MA (1) MA23953A1 (en)
MX (1) MX9800809A (en)
NO (1) NO980384L (en)
NZ (1) NZ315632A (en)
OA (1) OA10659A (en)
PL (1) PL325242A1 (en)
SK (1) SK11098A3 (en)
TR (1) TR199800156T1 (en)
UY (1) UY24297A1 (en)
WO (1) WO1997004750A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
KR20010034588A (en) * 1998-03-11 2001-04-25 피터 기딩스 Composition
FR2796840B1 (en) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques LOW-DOSE TABLETS AND METHOD OF PREPARATION
DK1591121T3 (en) 2000-12-14 2009-10-05 Ortho Mcneil Janssen Pharm Process for the preparation of steroid hormone products containing a stabilizer in non-crystalline form
JP2007532511A (en) * 2004-04-09 2007-11-15 スミスクライン ビーチャム コーポレーション Low dose medicine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (en) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd Wet solid pharmaceutical preparation of very small amount of main drug
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
DK0392803T3 (en) * 1989-04-13 2004-10-18 Beecham Group Plc Hitherto unknown compounds
ZA939565B (en) * 1993-12-21 1994-08-11 Applied Analytical Ind Inc Method for preparing low dose pharmaceutical products.

Also Published As

Publication number Publication date
AU6738496A (en) 1997-02-26
BG102266A (en) 1998-10-30
CZ24798A3 (en) 1998-06-17
NO980384D0 (en) 1998-01-28
OA10659A (en) 2002-09-18
MA23953A1 (en) 1997-04-01
DZ2077A1 (en) 2002-07-22
EA199800179A1 (en) 1998-10-29
SK11098A3 (en) 1998-07-08
CN1196677A (en) 1998-10-21
WO1997004750A2 (en) 1997-02-13
CA2228048A1 (en) 1997-02-13
AR004178A1 (en) 1998-11-04
PL325242A1 (en) 1998-07-06
NO980384L (en) 1998-03-26
AP858A (en) 2000-07-12
TR199800156T1 (en) 1998-04-21
EP0841902A2 (en) 1998-05-20
HUP9900521A3 (en) 2001-04-28
EA000740B1 (en) 2000-02-28
WO1997004750A3 (en) 1997-03-27
MX9800809A (en) 1998-04-30
AP9801170A0 (en) 1998-01-31
BR9609804A (en) 1999-07-06
NZ315632A (en) 1999-11-29
IL122897A0 (en) 1998-08-16
AU716961B2 (en) 2000-03-09
HUP9900521A2 (en) 1999-06-28
JPH11510493A (en) 1999-09-14
KR19990035972A (en) 1999-05-25
UY24297A1 (en) 1997-01-23

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