HUP9900519A1 - Benzociklobutánszármazékok, eljárás előállításukra, és ezeket tartalmazó gyógyászati készítmények - Google Patents

Benzociklobutánszármazékok, eljárás előállításukra, és ezeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9900519A1
HUP9900519A1 HU9900519A HUP9900519A HUP9900519A1 HU P9900519 A1 HUP9900519 A1 HU P9900519A1 HU 9900519 A HU9900519 A HU 9900519A HU P9900519 A HUP9900519 A HU P9900519A HU P9900519 A1 HUP9900519 A1 HU P9900519A1
Authority
HU
Hungary
Prior art keywords
general formula
pipe powder
atom
powder
integer
Prior art date
Application number
HU9900519A
Other languages
English (en)
Inventor
Mauricette Brocco
Aimée Dessinges
Jean-Christophe Harmange
Mark Millan
Adrian Newman-Tancredi
Jean-Louis Peglion
Original Assignee
Adir Et Compagnie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir Et Compagnie filed Critical Adir Et Compagnie
Publication of HU9900519D0 publication Critical patent/HU9900519D0/hu
Publication of HUP9900519A1 publication Critical patent/HUP9900519A1/hu
Publication of HU224310B1 publication Critical patent/HU224310B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Az (I) általánős képletű, új vegyületek - a képletben Z1, Z2, Z3 és Z4jelentése azőnősan vagy eltérően hidrőgénatőm, halőgénatőm, alkil-,alkenil-, alkinil-, alkil-, hidrőxil-, alkőxi-, benzilőxi-, alkenőxi-,alkinőxi-, cianő-, triflűőrmetil-, triflűőrmetőxi-, nitrő-, -OSO2CF3,-OSO2CH3, -NHCOCH3, -NHCOCF3, -NHSO2CH3 képletű csőpőrt, vagy (a) vagy(b) általánős képletű csőpőrt, X jelentése őxigénatőm, S(O)p-általánős képletű csőpőrt, amelyben p jelentése 0 és 2 közötti egészszám, -(CH2)n- általánős képletű csőpőrt, amelyben n értéke 1 és 4közötti egész szám, vagy -CH2-Y-CH2- általánős képletű csőpőrt,amelyben Y jelentése őxigénatőm, szelénatőm, vagy (c), (d) vagy (e)általánős képletű csőpőrt, A jelentése (f) vagy (g) általánős képletűcsőpőrt -, valamint izőmerjeik, és gyógyászatilag elfőgadható savakkalalkőtőtt addíciós sóik gyógyszerek hatóanyagaként különösendepresszió, pánikrőhamők, rögeszmés, kényszeres rendellenességek,fóbiák, impűlzív rendellenességek, drőggal való visszaélés ésszőrőngás kezelésére alkalmazhatók. ŕ
HU9900519A 1998-03-04 1999-03-03 1,2-Dihidrociklobutabenzol-származékok, és az ezeket tartalmazó gyógyászati készítmények HU224310B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9802585A FR2775687B1 (fr) 1998-03-04 1998-03-04 Nouveaux composes du benzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
HU9900519D0 HU9900519D0 (en) 1999-04-28
HUP9900519A1 true HUP9900519A1 (hu) 2000-08-28
HU224310B1 HU224310B1 (hu) 2005-07-28

Family

ID=9523607

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900519A HU224310B1 (hu) 1998-03-04 1999-03-03 1,2-Dihidrociklobutabenzol-származékok, és az ezeket tartalmazó gyógyászati készítmények

Country Status (19)

Country Link
US (1) US6107345A (hu)
EP (1) EP0940386B1 (hu)
JP (1) JP3676110B2 (hu)
CN (1) CN1137083C (hu)
AT (1) ATE217861T1 (hu)
AU (1) AU745808B2 (hu)
BR (1) BR9900850A (hu)
CA (1) CA2264372C (hu)
DE (1) DE69901522T2 (hu)
DK (1) DK0940386T3 (hu)
ES (1) ES2178357T3 (hu)
FR (1) FR2775687B1 (hu)
HK (1) HK1021895A1 (hu)
HU (1) HU224310B1 (hu)
NO (1) NO312096B1 (hu)
NZ (1) NZ334447A (hu)
PL (1) PL331729A1 (hu)
PT (1) PT940386E (hu)
ZA (1) ZA991748B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807753B1 (fr) * 2000-04-13 2002-06-07 Adir Nouveaux derives d'heterocycloalkylbenzocyclobutane et d'heteroarylbenzocyclobutane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2010072409A1 (en) * 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Process for preparation of ivabradine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214055A (en) * 1990-05-18 1993-05-25 Adir Et Compagnie Aminopiperidine 4-oxo-4H-chromen-2-yl compounds
FR2662162B1 (fr) * 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ES2178357T3 (es) 2002-12-16
DE69901522T2 (de) 2003-01-09
HK1021895A1 (en) 2000-07-14
EP0940386B1 (fr) 2002-05-22
NZ334447A (en) 2000-01-28
PL331729A1 (en) 1999-09-13
NO991043D0 (no) 1999-03-03
NO991043L (no) 1999-09-06
JPH11310557A (ja) 1999-11-09
AU745808B2 (en) 2002-04-11
CA2264372A1 (fr) 1999-09-04
HU9900519D0 (en) 1999-04-28
ATE217861T1 (de) 2002-06-15
DK0940386T3 (da) 2002-09-16
CN1228414A (zh) 1999-09-15
DE69901522D1 (de) 2002-06-27
US6107345A (en) 2000-08-22
PT940386E (pt) 2002-09-30
CA2264372C (fr) 2003-07-08
EP0940386A1 (fr) 1999-09-08
JP3676110B2 (ja) 2005-07-27
HU224310B1 (hu) 2005-07-28
FR2775687B1 (fr) 2000-04-14
AU1861899A (en) 2000-06-08
NO312096B1 (no) 2002-03-18
FR2775687A1 (fr) 1999-09-10
CN1137083C (zh) 2004-02-04
ZA991748B (en) 1999-09-16
BR9900850A (pt) 2000-05-02

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HFG4 Patent granted, date of granting

Effective date: 20050613

MM4A Lapse of definitive patent protection due to non-payment of fees