HUP9802531A2 - Method of mobilizing hematopoietic stem cells - Google Patents

Method of mobilizing hematopoietic stem cells

Info

Publication number
HUP9802531A2
HUP9802531A2 HU9802531A HUP9802531A HUP9802531A2 HU P9802531 A2 HUP9802531 A2 HU P9802531A2 HU 9802531 A HU9802531 A HU 9802531A HU P9802531 A HUP9802531 A HU P9802531A HU P9802531 A2 HUP9802531 A2 HU P9802531A2
Authority
HU
Hungary
Prior art keywords
stem cells
hematopoietic stem
mobilizing hematopoietic
mobilizing
grőg
Prior art date
Application number
HU9802531A
Other languages
Hungarian (hu)
Inventor
Andrew Garrison King
Louis Martin Pelus
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HUP9802531A2 publication Critical patent/HUP9802531A2/en
Publication of HUP9802531A3 publication Critical patent/HUP9802531A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány KC, grőb, grőa vagy grőg természetes, módősítőtt vagyműltimer főrmáinak gyógyszerkészítmények előállítására történőfelhasználására vőnatkőzik. Az ilyen gyógyszerkészítmények ahaematőpőeticűs stem sejteknek a csőntvelőből a periferiáliskeringésbe történő mőbilizációjára alkalmazhatók. ŕThe invention is intended for the use of KC, grőb, grőa or natural, modified or artificial forms of grőg for the production of pharmaceutical preparations. Such medicinal preparations can be used for the mobilization of hematopoietic stem cells from the marrow to the peripheral circulation. ŕ

HU9802531A 1995-10-24 1996-10-24 Method of mobilizing hematopoietic stem cells HUP9802531A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54726295A 1995-10-24 1995-10-24

Publications (2)

Publication Number Publication Date
HUP9802531A2 true HUP9802531A2 (en) 1999-02-01
HUP9802531A3 HUP9802531A3 (en) 2001-08-28

Family

ID=24183989

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802531A HUP9802531A3 (en) 1995-10-24 1996-10-24 Method of mobilizing hematopoietic stem cells

Country Status (14)

Country Link
EP (1) EP0866806A4 (en)
JP (1) JPH11512747A (en)
KR (1) KR19990066997A (en)
AR (1) AR004093A1 (en)
AU (1) AU712235B2 (en)
BR (1) BR9611173A (en)
CZ (1) CZ120298A3 (en)
HU (1) HUP9802531A3 (en)
NO (1) NO981818L (en)
NZ (1) NZ321789A (en)
PL (1) PL326364A1 (en)
TR (1) TR199800742T2 (en)
WO (1) WO1997015595A1 (en)
ZA (1) ZA968896B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US6042821A (en) * 1995-11-21 2000-03-28 Smithkline Beecham Corporation Method of treating sepsis with chemokines
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
AU1596299A (en) * 1997-11-26 1999-06-15 Smithkline Beecham Corporation Method of mobilizing hematopoietic stem cells
CA2339900A1 (en) * 1999-06-08 2000-12-14 Transgene S.A. Composition for implementing a cytotoxic, in particular an antitumoral or antiviral, treatment in a mammal
US20030175238A1 (en) * 2000-06-30 2003-09-18 Narendra Bam Chemokine conjugates
JP3563366B2 (en) 2001-05-07 2004-09-08 独立行政法人 科学技術振興機構 Protein multimers with unfolding activity on protein conformation
IL146970A0 (en) * 2001-12-06 2002-08-14 Yeda Res & Dev Migration of haematopoietic stem cells and progenitor cells to the liver
US7375192B2 (en) 2002-05-01 2008-05-20 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
AU2011329647B2 (en) 2010-11-19 2015-10-22 Eisai R&D Management Co., Ltd. Neutralizing anti-CCL20 antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713495B1 (en) * 1993-06-08 2003-11-05 Smithkline Beecham Corporation Methods of enhancing bioactivity of chemokines
GB9426012D0 (en) * 1994-12-22 1995-02-22 British Biotech Pharm Mobilisation of haematopoietic cells
GB9517014D0 (en) * 1995-08-19 1995-10-25 British Biotech Pharm Haematopoietic recovery

Also Published As

Publication number Publication date
CZ120298A3 (en) 1998-09-16
JPH11512747A (en) 1999-11-02
MX9803217A (en) 1998-09-30
EP0866806A4 (en) 2002-01-09
KR19990066997A (en) 1999-08-16
AR004093A1 (en) 1998-09-30
BR9611173A (en) 1999-03-30
HUP9802531A3 (en) 2001-08-28
EP0866806A1 (en) 1998-09-30
WO1997015595A1 (en) 1997-05-01
ZA968896B (en) 1997-04-24
AU712235B2 (en) 1999-11-04
PL326364A1 (en) 1998-09-14
NO981818D0 (en) 1998-04-23
TR199800742T2 (en) 1998-08-21
NO981818L (en) 1998-06-17
NZ321789A (en) 2000-07-28
AU7520996A (en) 1997-05-15

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