HUP9802336A3 - A process for the preparation of anthracycline antibiotics - Google Patents

A process for the preparation of anthracycline antibiotics

Info

Publication number
HUP9802336A3
HUP9802336A3 HU9802336A HUP9802336A HUP9802336A3 HU P9802336 A3 HUP9802336 A3 HU P9802336A3 HU 9802336 A HU9802336 A HU 9802336A HU P9802336 A HUP9802336 A HU P9802336A HU P9802336 A3 HUP9802336 A3 HU P9802336A3
Authority
HU
Hungary
Prior art keywords
preparation
anthracycline antibiotics
anthracycline
antibiotics
Prior art date
Application number
HU9802336A
Other languages
English (en)
Original Assignee
Sicor Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Spa filed Critical Sicor Spa
Publication of HUP9802336A2 publication Critical patent/HUP9802336A2/hu
Publication of HUP9802336A3 publication Critical patent/HUP9802336A3/hu
Publication of HU225413B1 publication Critical patent/HU225413B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
HU9802336A 1995-03-22 1996-03-19 A process for the preparation of anthracycline antibiotics HU225413B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI000566A IT1275953B1 (it) 1995-03-22 1995-03-22 Procedimento per la preparazione di antibiotici della classe delle antracicline
PCT/EP1996/001174 WO1996029335A1 (en) 1995-03-22 1996-03-19 A process for the preparation of anthracycline antibiotics

Publications (3)

Publication Number Publication Date
HUP9802336A2 HUP9802336A2 (hu) 1999-02-01
HUP9802336A3 true HUP9802336A3 (en) 1999-11-29
HU225413B1 HU225413B1 (en) 2006-11-28

Family

ID=11371011

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802336A HU225413B1 (en) 1995-03-22 1996-03-19 A process for the preparation of anthracycline antibiotics

Country Status (14)

Country Link
US (1) US5945518A (hu)
EP (1) EP0819132B1 (hu)
JP (1) JP3983803B2 (hu)
AT (1) ATE181079T1 (hu)
AU (1) AU704101B2 (hu)
DE (1) DE69602834T2 (hu)
DK (1) DK0819132T3 (hu)
ES (1) ES2132901T3 (hu)
GR (1) GR3031195T3 (hu)
HU (1) HU225413B1 (hu)
IL (1) IL117545A (hu)
IT (1) IT1275953B1 (hu)
PL (1) PL182790B1 (hu)
WO (1) WO1996029335A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0848009T1 (en) * 1996-12-16 2000-12-31 Pharmachemie B.V. A process for preparing epirubicin or acid addition salts thereof from daunorubicin
KR100785966B1 (ko) * 2000-08-10 2007-12-14 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100850408B1 (ko) * 2000-08-10 2008-08-04 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
EP2636676A3 (en) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCl
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin
CN105229019B (zh) * 2013-07-02 2017-12-12 浙江海正药业股份有限公司 表阿霉素的制备方法及其中间体
CN104861014B (zh) * 2015-06-03 2017-09-29 道中道（菏泽）制药有限公司 一种盐酸表阿霉素结晶的制备方法
WO2017120729A1 (zh) * 2016-01-11 2017-07-20 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
GB2182926B (en) * 1985-11-19 1989-10-04 Erba Farmitalia Nitro anthracyclines, process for their preparation and use thereof
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
IT1196503B (it) * 1986-07-16 1988-11-16 Erba Farmitalia Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin

Also Published As

Publication number Publication date
ES2132901T3 (es) 1999-08-16
IL117545A (en) 2000-02-17
JPH11502215A (ja) 1999-02-23
ITMI950566A0 (it) 1995-03-22
DE69602834T2 (de) 1999-10-07
IT1275953B1 (it) 1997-10-24
PL322360A1 (en) 1998-01-19
MX9707126A (es) 1997-11-29
DK0819132T3 (da) 1999-12-27
IL117545A0 (en) 1996-07-23
ITMI950566A1 (it) 1996-09-22
PL182790B1 (pl) 2002-02-28
GR3031195T3 (en) 1999-12-31
ATE181079T1 (de) 1999-06-15
HU225413B1 (en) 2006-11-28
WO1996029335A1 (en) 1996-09-26
AU704101B2 (en) 1999-04-15
AU5110496A (en) 1996-10-08
EP0819132B1 (en) 1999-06-09
DE69602834D1 (de) 1999-07-15
JP3983803B2 (ja) 2007-09-26
HUP9802336A2 (hu) 1999-02-01
US5945518A (en) 1999-08-31
EP0819132A1 (en) 1998-01-21

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees