HUP9802336A2 - Eljárás antraciklin antibiotikumok előállítására - Google Patents

Eljárás antraciklin antibiotikumok előállítására

Info

Publication number
HUP9802336A2
HUP9802336A2 HU9802336A HUP9802336A HUP9802336A2 HU P9802336 A2 HUP9802336 A2 HU P9802336A2 HU 9802336 A HU9802336 A HU 9802336A HU P9802336 A HUP9802336 A HU P9802336A HU P9802336 A2 HUP9802336 A2 HU P9802336A2
Authority
HU
Hungary
Prior art keywords
hydroxyl
ring
tube powder
molecule
preparation
Prior art date
Application number
HU9802336A
Other languages
English (en)
Inventor
Francesco Bianchi
Ettore Bigatti
Original Assignee
Sicor Societa' Italiana Corticosteroidi S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Societa' Italiana Corticosteroidi S.P.A. filed Critical Sicor Societa' Italiana Corticosteroidi S.P.A.
Publication of HUP9802336A2 publication Critical patent/HUP9802336A2/hu
Publication of HUP9802336A3 publication Critical patent/HUP9802336A3/hu
Publication of HU225413B1 publication Critical patent/HU225413B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

A találmány tárgya eljárás az (A) általánős képletű antraciklin típűsúantibiőtikűmők előállítására, a képletben R1 jelentése hidrőgénatőm vagy hidrőxilcsőpőrt, vagy -OCOR2 álta-lánősképletű csőpőrt, ahől, R2 jelentése 1-4 szénatőmős alkilcsőpőrt. Az eljárás sőrán a daűnózamin mőlekűlarész 4'-hidrőxilcsőpőrtjátepimerizálják őly módőn, hőgy a triflűőr-metil-szűlfőnil-csőpőrtőtnűkleőfil szűbsztitúcióval karbőxilátra cserélik, az epimerizáció és atővábbi átalakítási eljárásők főlyamán a mőlekűla hidrőxilcsőpőrtjaivédettek. ŕ
HU9802336A 1995-03-22 1996-03-19 A process for the preparation of anthracycline antibiotics HU225413B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI000566A IT1275953B1 (it) 1995-03-22 1995-03-22 Procedimento per la preparazione di antibiotici della classe delle antracicline
PCT/EP1996/001174 WO1996029335A1 (en) 1995-03-22 1996-03-19 A process for the preparation of anthracycline antibiotics

Publications (3)

Publication Number Publication Date
HUP9802336A2 true HUP9802336A2 (hu) 1999-02-01
HUP9802336A3 HUP9802336A3 (en) 1999-11-29
HU225413B1 HU225413B1 (en) 2006-11-28

Family

ID=11371011

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802336A HU225413B1 (en) 1995-03-22 1996-03-19 A process for the preparation of anthracycline antibiotics

Country Status (14)

Country Link
US (1) US5945518A (hu)
EP (1) EP0819132B1 (hu)
JP (1) JP3983803B2 (hu)
AT (1) ATE181079T1 (hu)
AU (1) AU704101B2 (hu)
DE (1) DE69602834T2 (hu)
DK (1) DK0819132T3 (hu)
ES (1) ES2132901T3 (hu)
GR (1) GR3031195T3 (hu)
HU (1) HU225413B1 (hu)
IL (1) IL117545A (hu)
IT (1) IT1275953B1 (hu)
PL (1) PL182790B1 (hu)
WO (1) WO1996029335A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0848009T1 (en) * 1996-12-16 2000-12-31 Pharmachemie B.V. A process for preparing epirubicin or acid addition salts thereof from daunorubicin
KR100785966B1 (ko) * 2000-08-10 2007-12-14 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100850408B1 (ko) * 2000-08-10 2008-08-04 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
EP2636676A3 (en) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCl
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin
CN105229019B (zh) * 2013-07-02 2017-12-12 浙江海正药业股份有限公司 表阿霉素的制备方法及其中间体
CN104861014B (zh) * 2015-06-03 2017-09-29 道中道（菏泽）制药有限公司 一种盐酸表阿霉素结晶的制备方法
WO2017120729A1 (zh) * 2016-01-11 2017-07-20 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
GB2182926B (en) * 1985-11-19 1989-10-04 Erba Farmitalia Nitro anthracyclines, process for their preparation and use thereof
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
IT1196503B (it) * 1986-07-16 1988-11-16 Erba Farmitalia Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin

Also Published As

Publication number Publication date
ES2132901T3 (es) 1999-08-16
HUP9802336A3 (en) 1999-11-29
IL117545A (en) 2000-02-17
JPH11502215A (ja) 1999-02-23
ITMI950566A0 (it) 1995-03-22
DE69602834T2 (de) 1999-10-07
IT1275953B1 (it) 1997-10-24
PL322360A1 (en) 1998-01-19
MX9707126A (es) 1997-11-29
DK0819132T3 (da) 1999-12-27
IL117545A0 (en) 1996-07-23
ITMI950566A1 (it) 1996-09-22
PL182790B1 (pl) 2002-02-28
GR3031195T3 (en) 1999-12-31
ATE181079T1 (de) 1999-06-15
HU225413B1 (en) 2006-11-28
WO1996029335A1 (en) 1996-09-26
AU704101B2 (en) 1999-04-15
AU5110496A (en) 1996-10-08
EP0819132B1 (en) 1999-06-09
DE69602834D1 (de) 1999-07-15
JP3983803B2 (ja) 2007-09-26
US5945518A (en) 1999-08-31
EP0819132A1 (en) 1998-01-21

Similar Documents

Publication Publication Date Title
HUP9802336A2 (hu) Eljárás antraciklin antibiotikumok előállítására
PH31610A (en) Taxol derivatives.
HU907105D0 (en) Process for producing new polypeptones
MY119192A (en) Intermediates useful for the production of morpholinyl derivatives of doxorubicin and process for their preparation.
ES8708227A1 (es) Un procedimiento para preparar acido 7beta-(metiltio-fluorado)acetamido-7alfa-metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)tiometil-1-destia-1-oxa-3-cefem-4-carboxilico.
HUT46924A (en) Process for producing tylosin and 10,11,12,13-tetrahydro-tylosin derivatives
AU617188B2 (en) Azepines
ES8306765A1 (es) "un procedimiento para preparar un derivado de antraciclina".
IL113744A0 (en) 3-Cephem derivatives and their preparation
HUP9903806A2 (hu) Eljárás kolchicionid vegyületek biológiai átalakítására a megfelelő 3-glikozil-származékokká
HUT58065A (en) Process for producing new 4'-epi-4'-aminoanthracyclines and pharmaceutical composiktions comprising same
MY103552A (en) Saccharide derivatives
UA35556C2 (uk) Спосіб одержання гідрокортизону та проміжні сполуки в синтезі гідрокортизону
HUT34213A (en) Process for the production of /1,2-diphenyl-ethylene-diamine/-platinum/ii-complex-derivates
ES476814A1 (es) Un procedimiento de produccion de antibioticos aminoglicosi-dos.
HUP9802942A2 (hu) Eljárás sztreptograminok előállítására
PH16357A (en) Indole and indoline derivatives and its pharmaceutical compositions
EP0596112A4 (en) Macrolide compound and its preparation.
AU1370895A (en) 2'-deoxy-5-fluorouridine derivative, pharmaceutically acceptable salt thereof, process for producing the same, and antitumor drug
MX9602586A (es) Preparacion de polioles que contienen grupos isocianurato.
GB1504832A (en) Gentamicin derivatives and methods of production thereof
ES442472A1 (es) Un procedimiento para la produccion de un derivado desmeti- lado.
EP0358161A3 (en) Novel anthracycline derivatives and process for production thereof

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees