HUP9802005A3 - Use of sodium-hydrogen-exchange-inhibitors for producing pharmaceutical compositions for reducing the cardiotoxic effect of some substances - Google Patents
Use of sodium-hydrogen-exchange-inhibitors for producing pharmaceutical compositions for reducing the cardiotoxic effect of some substancesInfo
- Publication number
- HUP9802005A3 HUP9802005A3 HU9802005A HUP9802005A HUP9802005A3 HU P9802005 A3 HUP9802005 A3 HU P9802005A3 HU 9802005 A HU9802005 A HU 9802005A HU P9802005 A HUP9802005 A HU P9802005A HU P9802005 A3 HUP9802005 A3 HU P9802005A3
- Authority
- HU
- Hungary
- Prior art keywords
- inhibitors
- substances
- exchange
- sodium
- hydrogen
- Prior art date
Links
- 230000001451 cardiotoxic effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19738604A DE19738604A1 (de) | 1997-09-04 | 1997-09-04 | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9802005D0 HU9802005D0 (en) | 1998-11-30 |
| HUP9802005A2 HUP9802005A2 (hu) | 1999-04-28 |
| HUP9802005A3 true HUP9802005A3 (en) | 2005-06-28 |
Family
ID=7841131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9802005A HUP9802005A3 (en) | 1997-09-04 | 1998-09-03 | Use of sodium-hydrogen-exchange-inhibitors for producing pharmaceutical compositions for reducing the cardiotoxic effect of some substances |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6462024B1 (hu) |
| EP (1) | EP0916337A3 (hu) |
| JP (1) | JP4555409B2 (hu) |
| KR (1) | KR19990029520A (hu) |
| CN (1) | CN1195508C (hu) |
| AR (1) | AR015718A1 (hu) |
| AU (1) | AU753899B2 (hu) |
| BR (1) | BR9803319A (hu) |
| CA (1) | CA2246633A1 (hu) |
| CZ (1) | CZ280898A3 (hu) |
| DE (1) | DE19738604A1 (hu) |
| HK (1) | HK1018212A1 (hu) |
| HR (1) | HRP980488A2 (hu) |
| HU (1) | HUP9802005A3 (hu) |
| IL (1) | IL126068A0 (hu) |
| NO (1) | NO984071L (hu) |
| NZ (1) | NZ331682A (hu) |
| PL (1) | PL328366A1 (hu) |
| RU (1) | RU2252754C2 (hu) |
| SK (1) | SK121198A3 (hu) |
| TR (1) | TR199801728A2 (hu) |
| TW (1) | TW592693B (hu) |
| ZA (1) | ZA988066B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7375138B2 (en) * | 2002-05-18 | 2008-05-20 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them |
| FR2840302B1 (fr) * | 2002-06-03 | 2004-07-16 | Aventis Pharma Sa | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| US6878748B2 (en) | 2002-06-13 | 2005-04-12 | Aventis Pharma Deutschland Gmbh | Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them |
| US7629493B2 (en) * | 2003-05-06 | 2009-12-08 | Merck Patent Gmbh | Process for the crystallisation of guandinium salts |
| CN112107568B (zh) * | 2019-06-19 | 2022-03-25 | 北京龙嘉博创医药科技有限公司 | 二芳基酰胺类化合物及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| DE4127026A1 (de) * | 1991-08-16 | 1993-02-18 | Boehringer Ingelheim Kg | Neue pyrazinderivate, ihre herstellung und verwendung |
| CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| ES2097409T3 (es) * | 1992-09-22 | 1997-04-01 | Hoechst Ag | Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos. |
| TW250479B (hu) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
| DE4337609A1 (de) * | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| DE4422685A1 (de) * | 1994-06-29 | 1996-01-04 | Hoechst Ag | Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4428480A1 (de) * | 1994-08-11 | 1996-03-07 | Hoechst Ag | Substituierte Benzoesäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Synthese von Inhibitoren des zellulären Na·+·/H·+·-Austauschs |
| DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
| DE4441880A1 (de) * | 1994-11-24 | 1996-05-30 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19734693A1 (de) * | 1997-08-11 | 1998-01-22 | Hoechst Marion Roussel De Gmbh | Verwendung von Cariporide als Inhibitor des zellulären NA+/H+-Exchangers (NHE) zur Herstellung eines Medikaments zur Behandlung von cardialen und nichtcardialen Krankheiten |
-
1997
- 1997-09-04 DE DE19738604A patent/DE19738604A1/de not_active Withdrawn
-
1998
- 1998-08-29 EP EP98116434A patent/EP0916337A3/de not_active Withdrawn
- 1998-09-01 BR BR9803319A patent/BR9803319A/pt not_active Application Discontinuation
- 1998-09-02 NZ NZ331682A patent/NZ331682A/en unknown
- 1998-09-02 SK SK1211-98A patent/SK121198A3/sk unknown
- 1998-09-02 AR ARP980104391A patent/AR015718A1/es unknown
- 1998-09-02 TR TR1998/01728A patent/TR199801728A2/xx unknown
- 1998-09-03 JP JP25017198A patent/JP4555409B2/ja not_active Expired - Fee Related
- 1998-09-03 CN CNB981188400A patent/CN1195508C/zh not_active Expired - Fee Related
- 1998-09-03 CZ CZ982808A patent/CZ280898A3/cs unknown
- 1998-09-03 HU HU9802005A patent/HUP9802005A3/hu unknown
- 1998-09-03 IL IL12606898A patent/IL126068A0/xx unknown
- 1998-09-03 ZA ZA988066A patent/ZA988066B/xx unknown
- 1998-09-03 AU AU83073/98A patent/AU753899B2/en not_active Ceased
- 1998-09-03 HR HR19738604.0A patent/HRP980488A2/hr not_active Application Discontinuation
- 1998-09-03 RU RU98116473/14A patent/RU2252754C2/ru not_active IP Right Cessation
- 1998-09-04 KR KR1019980036405A patent/KR19990029520A/ko not_active Application Discontinuation
- 1998-09-04 NO NO984071A patent/NO984071L/no not_active Application Discontinuation
- 1998-09-04 CA CA002246633A patent/CA2246633A1/en not_active Abandoned
- 1998-09-04 PL PL98328366A patent/PL328366A1/xx unknown
- 1998-09-23 TW TW087114509A patent/TW592693B/zh not_active IP Right Cessation
-
1999
- 1999-07-28 HK HK99103248A patent/HK1018212A1/xx not_active IP Right Cessation
-
2000
- 2000-07-11 US US09/614,122 patent/US6462024B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU8307398A (en) | 1999-03-18 |
| NZ331682A (en) | 2001-08-31 |
| PL328366A1 (en) | 1999-03-15 |
| HRP980488A2 (en) | 1999-06-30 |
| AU753899B2 (en) | 2002-10-31 |
| BR9803319A (pt) | 2000-03-21 |
| NO984071L (no) | 1999-03-05 |
| RU2252754C2 (ru) | 2005-05-27 |
| JP4555409B2 (ja) | 2010-09-29 |
| TR199801728A2 (xx) | 1999-04-21 |
| SK121198A3 (en) | 1999-03-12 |
| EP0916337A2 (de) | 1999-05-19 |
| HU9802005D0 (en) | 1998-11-30 |
| HK1018212A1 (en) | 1999-12-17 |
| IL126068A0 (en) | 1999-05-09 |
| JPH11180896A (ja) | 1999-07-06 |
| US6462024B1 (en) | 2002-10-08 |
| CN1209995A (zh) | 1999-03-10 |
| ZA988066B (en) | 1999-03-11 |
| NO984071D0 (no) | 1998-09-04 |
| CZ280898A3 (cs) | 1999-03-17 |
| CN1195508C (zh) | 2005-04-06 |
| AR015718A1 (es) | 2001-05-16 |
| KR19990029520A (ko) | 1999-04-26 |
| CA2246633A1 (en) | 1999-03-04 |
| EP0916337A3 (de) | 2004-03-17 |
| DE19738604A1 (de) | 1999-03-11 |
| TW592693B (en) | 2004-06-21 |
| HUP9802005A2 (hu) | 1999-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |