HUP9801409A2 - APO B szekréció és/vagy MTP-gátló hatású tetrahidroizokinolinszármazék, eljárás előállítására és ezt a vegyületet tartalmazó gyógyszerkészítmény - Google Patents

APO B szekréció és/vagy MTP-gátló hatású tetrahidroizokinolinszármazék, eljárás előállítására és ezt a vegyületet tartalmazó gyógyszerkészítmény

Info

Publication number
HUP9801409A2
HUP9801409A2 HU9801409A HUP9801409A HUP9801409A2 HU P9801409 A2 HUP9801409 A2 HU P9801409A2 HU 9801409 A HU9801409 A HU 9801409A HU P9801409 A HUP9801409 A HU P9801409A HU P9801409 A2 HUP9801409 A2 HU P9801409A2
Authority
HU
Hungary
Prior art keywords
tetrahydroisoquinolin
apo
secretion
derivative
producing
Prior art date
Application number
HU9801409A
Other languages
English (en)
Inventor
George Chang
George Joseph Quallich
Lewin Theophilus Wint
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HU9801409D0 publication Critical patent/HU9801409D0/hu
Publication of HUP9801409A2 publication Critical patent/HUP9801409A2/hu
Publication of HUP9801409A3 publication Critical patent/HUP9801409A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
HU9801409A 1997-06-23 1998-06-22 Tetrahydroisoquinolin derivative as apo b-secretion or/and mtp inhibitor, process for producing it and pharmaceutical composition containing it HUP9801409A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5051497P 1997-06-23 1997-06-23

Publications (3)

Publication Number Publication Date
HU9801409D0 HU9801409D0 (en) 1998-08-28
HUP9801409A2 true HUP9801409A2 (hu) 1999-05-28
HUP9801409A3 HUP9801409A3 (en) 1999-06-28

Family

ID=21965680

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801409A HUP9801409A3 (en) 1997-06-23 1998-06-22 Tetrahydroisoquinolin derivative as apo b-secretion or/and mtp inhibitor, process for producing it and pharmaceutical composition containing it

Country Status (10)

Country Link
US (1) US5968950A (hu)
EP (1) EP0887345A1 (hu)
JP (1) JPH1160557A (hu)
KR (1) KR19990007203A (hu)
AU (1) AU7310198A (hu)
CA (1) CA2241164A1 (hu)
HU (1) HUP9801409A3 (hu)
IL (1) IL124993A0 (hu)
NZ (1) NZ330766A (hu)
ZA (1) ZA985416B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19933926A1 (de) * 1999-07-20 2001-01-25 Boehringer Ingelheim Pharma Biphenylderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
CA2324800A1 (en) * 1999-11-10 2001-05-10 Mary Anne Hickman Use of apo b secretion/mtp inhibitors
CA2324801A1 (en) * 1999-11-10 2001-05-10 Andrew Gordon Swick Use of apo b secretion/mtp inhibitors and anti-obesity agents
IL139449A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Use of apo b secretion/mtp inhibitors
IL139450A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
AU2001262185A1 (en) * 2000-04-10 2001-10-23 Novartis Ag Substituted (hetero)aryl carboxamide derivatives as microsomal triglyceride transfer protein (mtp) and apolipoprotein b (apo b) secretion
DE10033337A1 (de) * 2000-07-08 2002-01-17 Boehringer Ingelheim Pharma Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
JO2654B1 (en) * 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) * 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
IL158516A0 (en) * 2001-06-28 2004-05-12 Pfizer Prod Inc Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (mtp) and/or apolipoprotein b (apo b) secretion
WO2004039795A2 (en) * 2002-10-29 2004-05-13 Fujisawa Pharmaceutical Co., Ltd. Amide compounds for the treatment of hyperlipidemia
BR0317323A (pt) * 2002-12-20 2005-11-16 Pfizer Prod Inc Inibidores de proteìna de transferência de triglicerìdeos microssomal
CA2510815A1 (en) * 2002-12-20 2004-07-08 Pfizer Products Inc. Microsomal triglyceride transfer protein inhibitors
AP2006003685A0 (en) 2004-02-04 2006-08-31 Pfizer Prod Inc Substituted quinoline compounds
WO2006129193A2 (en) * 2005-05-27 2006-12-07 Pfizer Products Inc. Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
JP4854253B2 (ja) 2005-09-30 2012-01-18 国立大学法人佐賀大学 脂質代謝改善用組成物
JP5099808B2 (ja) 2006-05-29 2012-12-19 独立行政法人農業・食品産業技術総合研究機構 脂質代謝改善用組成物
KR101868086B1 (ko) 2014-02-18 2018-06-15 김순길 천공 및 그라우팅 로드장치
KR102659328B1 (ko) 2023-06-28 2024-04-18 임정근 저심도 그라우팅 장치 및 이를 이용한 그라우팅 공법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022900A (en) * 1970-09-09 1977-05-10 Marion Laboratories, Inc. Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
DE3377709D1 (en) * 1982-09-10 1988-09-22 Wellcome Found Benzoic acid derivatives
CA2091102C (en) * 1992-03-06 2009-05-26 John R. Ii Wetterau Microsomal triglyceride transfer protein
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
EP0832069B1 (en) * 1995-06-07 2003-03-05 Pfizer Inc. BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION
BR9714364A (pt) * 1996-11-27 2000-03-21 Pfizer Amidas inibidoras da secreção de apo b/mtp

Also Published As

Publication number Publication date
IL124993A0 (en) 1999-01-26
JPH1160557A (ja) 1999-03-02
NZ330766A (en) 1999-09-29
AU7310198A (en) 1998-12-24
KR19990007203A (ko) 1999-01-25
US5968950A (en) 1999-10-19
CA2241164A1 (en) 1998-12-23
ZA985416B (en) 1999-12-22
HUP9801409A3 (en) 1999-06-28
HU9801409D0 (en) 1998-08-28
EP0887345A1 (en) 1998-12-30

Similar Documents

Publication Publication Date Title
HUP9801409A3 (en) Tetrahydroisoquinolin derivative as apo b-secretion or/and mtp inhibitor, process for producing it and pharmaceutical composition containing it
HUP0003305A3 (en) Hiv protease inhibiting tetrahydro-pyrimid-2-on derivative, pharmaceutical compositions containing it and process for producing the compound
HUP0001285A3 (en) Pyrrolidine derivatives as protease inhibitors, process for producing them and pharmaceutical compositions containing them
HUP0003141A3 (en) 4-phenylpiperidine derivatives, process for producing them and pharmaceutical compositions containing them
IL135920A0 (en) 2-aryl -8-oxodihydropurine derivative, process for the preparation thereof, pharmaceutical composition containing the same and intermediate therefor
IL117237A0 (en) Pharmaceutical composition for piperidinoalkanol compounds
HUP0002893A3 (en) Substituted quinazoline derivatives, process for producing them and pharmaceutical compositions containing them
IL135377A0 (en) Pharmaceutical compositions comprising mtp inhibitors
ZA969248B (en) New aminoacid derivatives process for the manufacture thereof and pharmaceutical compositions containing thesse compounds
HUP0003608A3 (en) Tetrahydroisoquinoline derivatives, process for producing them and pharmaceutical compositions containing them
HUP0002057A3 (en) Indazole amide compounds, process for producing them, pharmaceutical compositions containing them and their intermediers
HUP9901739A3 (en) Aminoisoquinolines and aminothienopyridine derivatives, process for producing thereof and pharmaceutical compositions containing them
HUP9601034A2 (en) Aryl-alkyl-pyridazinone compounds, process for producing them, and pharmaceutical compositions containing them
HUP0102622A3 (en) Biphenyl derivatives, process for producing them and pharmaceutical compositions containing them
EG22337A (en) Process for preparing novel pharmaceutical compounds
HUP9801423A3 (en) Chromene derivatives, process for producing them and pharmaceutical compositions containing them
GB2304714B (en) New piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them
HU9802180D0 (en) Process for producing pharmaceutical compositions
HUP9801950A3 (en) 2-(arylphenyl-amino)-imidazoline derivatives, process for producing them and pharmaceutical compositions containing them
HUP0001551A3 (en) Improved method for producing thiazolidinediones, thiazolidinediones and pharmaceutical compositions containing the same
HUP0003823A2 (en) Cyanoguanidines process for producing them and pharmaceutical compositions containing them
HU9800396D0 (en) Pharmaceutical composition for treating dementia
HUP0202379A3 (en) New compounds, process for producing them and pharmaceutical compositions containing them
HUP0003766A3 (en) Isoguinolin derivatives, process for producing them and pharmaceutical compositions containing them
HUP9702227A3 (en) New benzopirane compounds, process for producing them and pharmaceutical composition containing them