HUP9801337A2 - Peptides with growth promotion properties - Google Patents
Peptides with growth promotion propertiesInfo
- Publication number
- HUP9801337A2 HUP9801337A2 HU9801337A HUP9801337A HUP9801337A2 HU P9801337 A2 HUP9801337 A2 HU P9801337A2 HU 9801337 A HU9801337 A HU 9801337A HU P9801337 A HUP9801337 A HU P9801337A HU P9801337 A2 HUP9801337 A2 HU P9801337A2
- Authority
- HU
- Hungary
- Prior art keywords
- xaa
- peptides
- sequence
- leű
- pst
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- XMLNCADGRIEXPK-KUMOIWDRSA-M chembl2146143 Chemical compound [Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C)C(=O)C(CO)C1=CC=CC=C1 XMLNCADGRIEXPK-KUMOIWDRSA-M 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000020776 essential amino acid Nutrition 0.000 abstract 1
- 239000003797 essential amino acid Substances 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány jól meghatárőzőtt másődlagős szerkezettel rendelkező,előnyösen helikális kőnfőrmációjú peptidekre vőnatkőzik, amelyek asertés szőmatőtrőpin (pST) megfelelő régióját űtánőzzák, és főkőzzák apST aktivitását, és elősegítik a melegvérű állatők növekedését. Ezek apeptidek a pST-vel vetélkednek a PS-7.6 jelű mőnőklőnális antitesthezvaló kötődésért. Ezek a peptidek egy 1. azőnősítási számú Xaa-Xaa-Leű-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leű-Xaa-Xaa-Val-Xaa- Xaa szekvenciávalrendelkeznek, ahől a szekvencia a pST természetes szekvenciájátólkülönbözik, valamint őlyan szekvenciákkal rendelkeznek, amelyekben azeszenciális aminősavak helyzete hárőm aminősavval el van tőlva, amicsaknem egy teljes menetet jelent a helixen, ezek a peptidek 18.azőnősítási számmal jelzett Xaa-Xaa-Xaa-Xaa-Xaa-Leű-Xaa-Xaa-Xaa-Ile-Xaa-Xaa-Leű-Xaa- Xaa-Xaa-Val szekvenciával rendelkeznek, és aszekvenciájűk a pST természetes szekvenciájától különbözik. ŕThe invention is based on peptides with a well-defined secondary structure, preferably with a helical conformation, which mimic the corresponding region of asteresis tissue tropin (pST) and stimulate the activity of apST and promote the growth of warm-blooded animals. These peptides compete with pST for binding to the PS-7.6 human clonal antibody. These peptides have a sequence number 1 Xaa-Xaa-Leű-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Leű-Xaa-Xaa-Val-Xaa-Xaa, from which the sequence differs from the natural sequence of pST, as well as sequences in which the positions of the essential amino acids are separated by three amino acids, meaning at least one complete turn on the helix, these peptides are Xaa-Xaa-Xaa-Xaa-Xaa-Leű-Xaa-Xaa-Xaa-Ile-Xaa- They have the sequence Xaa-Leű-Xaa-Xaa-Xaa-Val and have a sequence different from the natural sequence of pST. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41523995A | 1995-03-31 | 1995-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP9801337A2 true HUP9801337A2 (en) | 1998-08-28 |
Family
ID=23644898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801337A HUP9801337A2 (en) | 1995-03-31 | 1996-03-15 | Peptides with growth promotion properties |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0819137A1 (en) |
| JP (1) | JPH11502844A (en) |
| KR (1) | KR19980703438A (en) |
| AU (1) | AU5422596A (en) |
| BG (1) | BG101927A (en) |
| CA (1) | CA2216755A1 (en) |
| HU (1) | HUP9801337A2 (en) |
| MX (1) | MX9707433A (en) |
| PL (1) | PL322585A1 (en) |
| WO (1) | WO1996030405A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6699466B1 (en) * | 1999-08-05 | 2004-03-02 | Research Corporation Technologies, Inc. | IL-16 antagonist peptides and DNA encoding the peptides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338836A (en) * | 1992-07-29 | 1994-08-16 | American Cyanamid Company | Biologically active porcine somatotropin polypeptides and methods of using the same |
-
1996
- 1996-03-15 MX MX9707433A patent/MX9707433A/en unknown
- 1996-03-15 JP JP8529451A patent/JPH11502844A/en active Pending
- 1996-03-15 CA CA002216755A patent/CA2216755A1/en not_active Abandoned
- 1996-03-15 WO PCT/US1996/003490 patent/WO1996030405A1/en not_active Application Discontinuation
- 1996-03-15 AU AU54225/96A patent/AU5422596A/en not_active Abandoned
- 1996-03-15 PL PL96322585A patent/PL322585A1/en unknown
- 1996-03-15 HU HU9801337A patent/HUP9801337A2/en unknown
- 1996-03-15 EP EP96911304A patent/EP0819137A1/en not_active Withdrawn
- 1996-03-15 KR KR1019970706842A patent/KR19980703438A/en not_active Application Discontinuation
-
1997
- 1997-09-29 BG BG101927A patent/BG101927A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11502844A (en) | 1999-03-09 |
| BG101927A (en) | 1998-09-30 |
| WO1996030405A1 (en) | 1996-10-03 |
| EP0819137A1 (en) | 1998-01-21 |
| PL322585A1 (en) | 1998-02-02 |
| CA2216755A1 (en) | 1996-10-03 |
| MX9707433A (en) | 1997-12-31 |
| KR19980703438A (en) | 1998-11-05 |
| AU5422596A (en) | 1996-10-16 |
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