BG101927A - Peprides having growth acceleration properties - Google Patents

Peprides having growth acceleration properties

Info

Publication number
BG101927A
BG101927A BG101927A BG10192797A BG101927A BG 101927 A BG101927 A BG 101927A BG 101927 A BG101927 A BG 101927A BG 10192797 A BG10192797 A BG 10192797A BG 101927 A BG101927 A BG 101927A
Authority
BG
Bulgaria
Prior art keywords
xaa
leu
pst
sequence
thexaa
Prior art date
Application number
BG101927A
Other languages
Bulgarian (bg)
Inventor
Brian Buckwalter
Hong - Ming SHIEH
Bosco WANG
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of BG101927A publication Critical patent/BG101927A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The peptides have well expressed secondary structure, inparticular spiral type, and fully resemble the respective domainof the pig somatropine (pST). They increase the pST activity andaccelerate the growth of warm-blooded animals. The peptidescompete with pST for binding to PS-7 monoclonal antibody. Theycontain the sequence of theXaa-Xaa-Leu-Xaa-Xaa-IIe-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Va1-Xaa (SEQ IDNO:1) aminoacids which differs from the natural sequence of pST,and sequences where the position of the essential amino acids isshifted by three amino acids which is practically a whole turnalong the spiral length. These peptides also contain the sequenceof theXaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Ile-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Va1 (SEQ ID NO:18) aminoacids which also differs from the naturalpST sequence.10 claims
BG101927A 1995-03-31 1997-09-29 Peprides having growth acceleration properties BG101927A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41523995A 1995-03-31 1995-03-31
PCT/US1996/003490 WO1996030405A1 (en) 1995-03-31 1996-03-15 Peptides with growth promotion properties

Publications (1)

Publication Number Publication Date
BG101927A true BG101927A (en) 1998-09-30

Family

ID=23644898

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101927A BG101927A (en) 1995-03-31 1997-09-29 Peprides having growth acceleration properties

Country Status (10)

Country Link
EP (1) EP0819137A1 (en)
JP (1) JPH11502844A (en)
KR (1) KR19980703438A (en)
AU (1) AU5422596A (en)
BG (1) BG101927A (en)
CA (1) CA2216755A1 (en)
HU (1) HUP9801337A2 (en)
MX (1) MX9707433A (en)
PL (1) PL322585A1 (en)
WO (1) WO1996030405A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699466B1 (en) * 1999-08-05 2004-03-02 Research Corporation Technologies, Inc. IL-16 antagonist peptides and DNA encoding the peptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338836A (en) * 1992-07-29 1994-08-16 American Cyanamid Company Biologically active porcine somatotropin polypeptides and methods of using the same

Also Published As

Publication number Publication date
KR19980703438A (en) 1998-11-05
EP0819137A1 (en) 1998-01-21
WO1996030405A1 (en) 1996-10-03
PL322585A1 (en) 1998-02-02
CA2216755A1 (en) 1996-10-03
HUP9801337A2 (en) 1998-08-28
AU5422596A (en) 1996-10-16
JPH11502844A (en) 1999-03-09
MX9707433A (en) 1997-12-31

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