HUP9701381A2 - New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them - Google Patents

New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them

Info

Publication number
HUP9701381A2
HUP9701381A2 HU9701381A HUP9701381A HUP9701381A2 HU P9701381 A2 HUP9701381 A2 HU P9701381A2 HU 9701381 A HU9701381 A HU 9701381A HU P9701381 A HUP9701381 A HU P9701381A HU P9701381 A2 HUP9701381 A2 HU P9701381A2
Authority
HU
Hungary
Prior art keywords
alkyl
optionally substituted
alkoxy
dioxolo
new
Prior art date
Application number
HU9701381A
Other languages
Hungarian (hu)
Inventor
József Barkóczy
Zoltán Rátkai
Géza Szabó
Géza Schneider
Judit Cselenyák
István Gacsályi
Gábor Gigler
István Gyertyán
Attila Kovács
Gyula Simig
András Egyed
György Lévay
Annamária Simó
Tamás Szabados
Károly Tihanyi
Miklós Végh
László Balázs
Imre Domán
Zoltán Greff
Nagy Péter Kótay
Péter Seres
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9701381A priority Critical patent/HUP9701381A3/en
Publication of HU9701381D0 publication Critical patent/HU9701381D0/en
Priority to UA2000031380A priority patent/UA67749C2/en
Priority to SK177-2000A priority patent/SK1772000A3/en
Priority to RU2000106060/04A priority patent/RU2208013C2/en
Priority to BR9812120-0A priority patent/BR9812120A/en
Priority to CA002300302A priority patent/CA2300302A1/en
Priority to AU88181/98A priority patent/AU735490B2/en
Priority to CN98809765A priority patent/CN1109033C/en
Priority to AT98939781T priority patent/ATE252586T1/en
Priority to JP2000506210A priority patent/JP2001512730A/en
Priority to EP98939781A priority patent/EP1003749B1/en
Priority to DK98939781T priority patent/DK1003749T3/en
Priority to DE69819166T priority patent/DE69819166T2/en
Priority to US09/485,391 priority patent/US6562810B1/en
Priority to PL98338680A priority patent/PL338680A1/en
Priority to KR1020007001464A priority patent/KR20010022862A/en
Priority to NZ503300A priority patent/NZ503300A/en
Priority to PCT/HU1998/000075 priority patent/WO1999007707A1/en
Publication of HUP9701381A2 publication Critical patent/HUP9701381A2/en
Publication of HUP9701381A3 publication Critical patent/HUP9701381A3/en
Priority to NO20000655A priority patent/NO20000655L/en

Links

Abstract

8-Substituted-9H-1,3-dioxolo [4,5-h] [2,3] benzodiazepine derivatives (I) are new. 9H-1,3-Dioxolo- [4,5-H] [2,3] benzodiazepine derivatives of formula (I) and their acid addition salts and quaternary ammonium derivatives are new. X = CO or CH2; R1 = H, OH, alkoxy, alkanoyloxy, alkylsulphonyloxy or NR4R5; R4, R5 = H, alkoxy, 1-4C alkanoyl or 1-6C alkyl (optionally substituted by 5-6 membered (un)saturated heterocycle containing 1 or 2 N or N and O, or by N-[phenyl-(alkyl)]-N-(alkyl) amino (optionally ring substituted by 1-3 alkoxy); or NR4R5 = 5-10 membered heterocycle optionally containing a further N or O; or X-R1 = CN, tetrazolyl, CH=NOH or COR6; R6 = OH, alkoxy, phenoxy, naphthyloxy, or NH2 (optionally substituted by alkyl); R2 = NO2, NH2 or 1-4C alkanoylamino; R3 = H, alkyl or COR7; R7 = H; 1-6C alkyl (optionally substituted by 1-3 halo); alkoxy, phenoxy or pyridyl; phenyl or naphthyl (both optionally substituted by 1-3 substituents); or (CH2)nNR8R9; R8, R9 = H or alkyl (optionally substituted by phenyl (optionally substituted by 1-3 alkoxy)) or saturated 5-6 membered heterocycle containing one N or N and O; or NR8R9 = 5-6 membered (un)saturated heterocycle optionally containing a further N or O (optionally substituted by phenyl (itself optionally substituted by 1-3 halo or alkoxy)); n = 0-2; Y = H or Me; or Y + R3 = bond; provided that if Y = H or forms a bond with R3 and X = CH2, then R1 is not H; alkyl moieties have 1-4C unless specified otherwise. An Independent claim for the preparation of (I) is included.
HU9701381A 1997-08-12 1997-08-12 New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them HUP9701381A3 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
HU9701381A HUP9701381A3 (en) 1997-08-12 1997-08-12 New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them
UA2000031380A UA67749C2 (en) 1997-08-12 1998-07-08 8-substituted-9h-1,3-dioxolo-[4,5-h][2,3]benzodiazepine being inhibitors of the ampa/kainite receptor
PCT/HU1998/000075 WO1999007707A1 (en) 1997-08-12 1998-08-07 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE DERIVATIVES, AS AMPA/KAINATE RECEPTOR INHIBITORS
AT98939781T ATE252586T1 (en) 1997-08-12 1998-08-07 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-H//2, 3/BENZODIAZEPINE DERIVATIVES AS AMPA/KAINATE RECEPTOR INHIBITORS
DK98939781T DK1003749T3 (en) 1997-08-12 1998-08-07 8-Substituted-9H-1,3dioxolo / 4,5-h / 2,3-benzodiazepine derivatives as ampa / kainate receptor inhibitors
BR9812120-0A BR9812120A (en) 1997-08-12 1998-08-07 Derivatives of 9h-1, 3-dioxolo / 4,5-h // 2,3 / benzodiazepine 8, pharmaceutical composition and process for their preparation
CA002300302A CA2300302A1 (en) 1997-08-12 1998-08-07 8-substituted-9h-1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives, as ampa/kainate receptor inhibitors
AU88181/98A AU735490B2 (en) 1997-08-12 1998-08-07 8-substituted-9H-1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives, as ampa/kainate receptor inhibitors
CN98809765A CN1109033C (en) 1997-08-12 1998-08-07 8-substituted-9H-1,3-dioxolo/4,5-h/2,3/benzodiazepine derivatives, as Ampa/kainate receptor inhibitors
SK177-2000A SK1772000A3 (en) 1997-08-12 1998-08-07 8-substituted-9h-1,3-dioxolo(4,5-h)(2,3)benzodiazepine derivatives, as ampa/kainate receptor inhibitors
JP2000506210A JP2001512730A (en) 1997-08-12 1998-08-07 8-Substituted-9H-1,3-dioxolo [4,5-h] [2,3] benzodiazepine derivatives as AMPA / kainic acid receptor inhibitors
EP98939781A EP1003749B1 (en) 1997-08-12 1998-08-07 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h/2,3/BENZODIAZEPINE DERIVATES, AS AMPA/KAINATERECEPTOR INHIBITORS
RU2000106060/04A RU2208013C2 (en) 1997-08-12 1998-08-07 Derivatives of 8-substituted=9h-1,3-dioxol[4,5-h][2,3]- benzodiazepine as inhibitors of ampa/kainate receptor, method for their preparing, pharmaceutical composition based on thereof and method of treatment
DE69819166T DE69819166T2 (en) 1997-08-12 1998-08-07 8-SUBSTITUTED-9H-1,3-DIOXOLO / 4,5-H // 2,3 / BENZODIAZEPINE DERIVATIVES AS AMPA / CAINATE RECEPTOR INHIBITORS
US09/485,391 US6562810B1 (en) 1997-08-12 1998-08-07 8-substituted-9H-1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives, as AMPA/kainate receptor inhibitors
PL98338680A PL338680A1 (en) 1997-08-12 1998-08-07 8-substituted derivatives of 9-h-1,3-dioxolo/4,5-h/2,3-benzoidazepins as inhibitors of ampa/cainate receptors
KR1020007001464A KR20010022862A (en) 1997-08-12 1998-08-07 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE DERIVATIVES, AS AMPA/KAINATE RECEPTOR INHIBITORS
NZ503300A NZ503300A (en) 1997-08-12 1998-08-07 8-substituted-9H-1,3-dioxolo[4,5-H],[2,3]benzodiazepine derivatives, as AMPA/kainate receptor inhibitors
NO20000655A NO20000655L (en) 1997-08-12 2000-02-09 8-substituted-9H-1,3-Dioxolo / 4,5- h // 2,3 / benzodiazepine derivatives as AMPA / KAINAT receptor inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9701381A HUP9701381A3 (en) 1997-08-12 1997-08-12 New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them

Publications (3)

Publication Number Publication Date
HU9701381D0 HU9701381D0 (en) 1997-10-28
HUP9701381A2 true HUP9701381A2 (en) 1999-06-28
HUP9701381A3 HUP9701381A3 (en) 1999-08-30

Family

ID=89995496

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701381A HUP9701381A3 (en) 1997-08-12 1997-08-12 New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them

Country Status (1)

Country Link
HU (1) HUP9701381A3 (en)

Also Published As

Publication number Publication date
HU9701381D0 (en) 1997-10-28
HUP9701381A3 (en) 1999-08-30

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