DK1003749T3 - 8-Substituted-9H-1,3dioxolo / 4,5-h / 2,3-benzodiazepine derivatives as ampa / kainate receptor inhibitors - Google Patents

8-Substituted-9H-1,3dioxolo / 4,5-h / 2,3-benzodiazepine derivatives as ampa / kainate receptor inhibitors

Info

Publication number
DK1003749T3
DK1003749T3 DK98939781T DK98939781T DK1003749T3 DK 1003749 T3 DK1003749 T3 DK 1003749T3 DK 98939781 T DK98939781 T DK 98939781T DK 98939781 T DK98939781 T DK 98939781T DK 1003749 T3 DK1003749 T3 DK 1003749T3
Authority
DK
Denmark
Prior art keywords
substituted
ampa
3dioxolo
receptor inhibitors
formula
Prior art date
Application number
DK98939781T
Other languages
Danish (da)
Inventor
Zoltan Ratkai
Geza Schneider
Judit Cselenyak
Lasl Balazs
Imre Doman
Zoltan Greff
Peter Seres
Gabor Gigler
Istvan Gyertyan
Attila Kovacs
Andras Egyed
Karoly Tihanyi
J Zsef Barkoczy
Gyula Simig
Nagy Peter Kotay
Geza Szabo
Istvan Gacsalyi
Gyoergy Levay
Tamas Szabados
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9701380A external-priority patent/HUP9701380A3/en
Priority claimed from HU9701381A external-priority patent/HUP9701381A3/en
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of DK1003749T3 publication Critical patent/DK1003749T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The disclosure relates to a novel 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound of formula I and pharmaceutically acceptable quaternary ammonium salts thereof, a process for preparing the same, a pharmaceutical composition containing a 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound, and a method of treatment using the pharmaceutical composition. A complete description of the compound of formula I is found in the specification. The compounds of the general formula I possess unique competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect.
DK98939781T 1997-08-12 1998-08-07 8-Substituted-9H-1,3dioxolo / 4,5-h / 2,3-benzodiazepine derivatives as ampa / kainate receptor inhibitors DK1003749T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU9701380A HUP9701380A3 (en) 1997-08-12 1997-08-12 New 8-substituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them
HU9701381A HUP9701381A3 (en) 1997-08-12 1997-08-12 New 7,8-dihydro-8,8-disubstituted-9h-1,3-dioxolo-[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them
PCT/HU1998/000075 WO1999007707A1 (en) 1997-08-12 1998-08-07 8-SUBSTITUTED-9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE DERIVATIVES, AS AMPA/KAINATE RECEPTOR INHIBITORS

Publications (1)

Publication Number Publication Date
DK1003749T3 true DK1003749T3 (en) 2004-03-08

Family

ID=89995497

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98939781T DK1003749T3 (en) 1997-08-12 1998-08-07 8-Substituted-9H-1,3dioxolo / 4,5-h / 2,3-benzodiazepine derivatives as ampa / kainate receptor inhibitors

Country Status (18)

Country Link
US (1) US6562810B1 (en)
EP (1) EP1003749B1 (en)
JP (1) JP2001512730A (en)
KR (1) KR20010022862A (en)
CN (1) CN1109033C (en)
AT (1) ATE252586T1 (en)
AU (1) AU735490B2 (en)
BR (1) BR9812120A (en)
CA (1) CA2300302A1 (en)
DE (1) DE69819166T2 (en)
DK (1) DK1003749T3 (en)
NO (1) NO20000655L (en)
NZ (1) NZ503300A (en)
PL (1) PL338680A1 (en)
RU (1) RU2208013C2 (en)
SK (1) SK1772000A3 (en)
UA (1) UA67749C2 (en)
WO (1) WO1999007707A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900354A3 (en) * 1999-02-15 2001-02-28 Egyt Gyogyszervegyeszeti Gyar Use of condensed 2,3-benzodiazepine derivatives for the preparation of pharmaceutical compositions treating and preventing diseases related with the inhibition of lipide peroxidation
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
US6858605B2 (en) 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
CN100558834C (en) * 2006-07-21 2009-11-11 华南理工大学 A kind of green powdered paint and preparation method thereof
FR2972454B1 (en) * 2011-03-08 2013-03-01 Servier Lab NOVEL DIHYDRO-OXAZOLOBENZODIAZEPINONES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
HU230684B1 (en) * 2014-01-21 2017-08-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag New dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
CN104391999B (en) * 2014-12-15 2018-02-02 北京国双科技有限公司 Information recommendation method and device
US10335503B2 (en) * 2015-07-06 2019-07-02 Public University Corporation Yokohama City University Compound that specifically binds to AMPA receptor
RU2634594C1 (en) * 2016-11-30 2017-11-01 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Inhibitors of formation of glycation end products based on azo-derivative phenylsulphonic acids
JPWO2023042887A1 (en) 2021-09-15 2023-03-23
JPWO2023042888A1 (en) 2021-09-15 2023-03-23

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU206719B (en) 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (en) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Process for producing n-acyl-2,3-benzodiazepine derivatives, their acid additional salts and pharmaceutical compositions containing them and a grop of the compounds and pharmaceutical compositions containing them
HU219777B (en) 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optical active 1-(4-nitrophenyl)-4-methyl-7,8-methylen dioxi-3,4-dihydro-5h-2,3-benzodiazepine and process for producing it
DE4428835A1 (en) * 1994-08-01 1996-02-08 Schering Ag New 3-substituted 3H-2,3-benzodiazepine derivatives, their production and use as medicines
TR199501070A2 (en) * 1994-08-31 1996-06-21 Lilly Co Eli Crystalline form of the dihydro-2,3-benzodiazepine derivative.
TR199501071A2 (en) * 1994-08-31 1996-06-21 Lilly Co Eli Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives.
DE19604919A1 (en) * 1996-02-01 1997-08-07 Schering Ag New 2,3-benzodiazepine derivatives, their production and use as medicines

Also Published As

Publication number Publication date
JP2001512730A (en) 2001-08-28
EP1003749B1 (en) 2003-10-22
NZ503300A (en) 2001-06-29
US6562810B1 (en) 2003-05-13
SK1772000A3 (en) 2000-10-09
DE69819166D1 (en) 2003-11-27
NO20000655L (en) 2000-04-10
RU2208013C2 (en) 2003-07-10
CN1272846A (en) 2000-11-08
BR9812120A (en) 2001-11-20
DE69819166T2 (en) 2004-07-22
KR20010022862A (en) 2001-03-26
ATE252586T1 (en) 2003-11-15
CN1109033C (en) 2003-05-21
PL338680A1 (en) 2000-11-20
AU735490B2 (en) 2001-07-12
AU8818198A (en) 1999-03-01
EP1003749A1 (en) 2000-05-31
NO20000655D0 (en) 2000-02-09
UA67749C2 (en) 2004-07-15
CA2300302A1 (en) 1999-02-18
WO1999007707A1 (en) 1999-02-18

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