HUP9701383A2 - New 8-methyl-7h-1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them - Google Patents

New 8-methyl-7h-1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them

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Publication number
HUP9701383A2
HUP9701383A2 HU9701383A HUP9701383A HUP9701383A2 HU P9701383 A2 HUP9701383 A2 HU P9701383A2 HU 9701383 A HU9701383 A HU 9701383A HU P9701383 A HUP9701383 A HU P9701383A HU P9701383 A2 HUP9701383 A2 HU P9701383A2
Authority
HU
Hungary
Prior art keywords
optionally substituted
alkoxy
phenyl
dioxolo
new
Prior art date
Application number
HU9701383A
Other languages
Hungarian (hu)
Inventor
József Barkóczy
Judit Cselenyák
Zoltán Rátkai
Géza Szabó
István Gacsályi
Gábor Gigler
István Gyertyán
Attila Kovács
Gyula Simig
András Egyed
György Lévay
Annamária Simó
Tamás Szabados
Károly Tihanyi
Miklós Végh
László Balázs
Imre Domán
Zoltán Greff
Nagy Péter Kótay
Péter Seres
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9701383A priority Critical patent/HUP9701383A3/en
Publication of HU9701383D0 publication Critical patent/HU9701383D0/en
Priority to PL98338681A priority patent/PL338681A1/en
Priority to JP2000506211A priority patent/JP2001512731A/en
Priority to EP98939782A priority patent/EP1015457B1/en
Priority to PCT/HU1998/000076 priority patent/WO1999007708A1/en
Priority to CA002300142A priority patent/CA2300142A1/en
Priority to BR9812119-7A priority patent/BR9812119A/en
Priority to KR1020007001458A priority patent/KR20010022856A/en
Priority to AT98939782T priority patent/ATE255112T1/en
Priority to AU88182/98A priority patent/AU748801B2/en
Priority to NZ503301A priority patent/NZ503301A/en
Priority to CN98809317A priority patent/CN1271360A/en
Priority to DE69820081T priority patent/DE69820081D1/en
Priority to RU2000106061/04A priority patent/RU2208014C2/en
Priority to SK179-2000A priority patent/SK1792000A3/en
Publication of HUP9701383A2 publication Critical patent/HUP9701383A2/en
Publication of HUP9701383A3 publication Critical patent/HUP9701383A3/en
Priority to NO20000654A priority patent/NO20000654L/en

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Abstract

1,3-Dioxolo[4,5-h][2,3] benzodiazepine derivatives (I) are new. 1,3-Dioxolo [4,5-h] [2,3] benzodiazepine derivatives of formula (I) and their acid addition salts are new. (i) A, B = H; R1 = (CH2)n-CO(CH2)mR; R = halo, pyridyl or NR3R4; R3, R4 = H, cycloalkyl, alkoxy, amino, phenyl (optionally substituted by one or two alkyl), alkyl (optionally substituted by phenyl ) or saturated 5-6 membered heterocycle containing 1-3 N or one N plus one O (optionally substituted by phenyl, itself optionally substituted by 1-3 alkoxy); or NR3R4 = (un)saturated 5-6 membered heterocycle optionally containing a further N or S (optionally substituted by phenyl, itself optionally substituted by 1-3 alkoxy); n = 0-2; m = 0-2; or (ii) A + B = a bond; R1 = CO(CH2)pR6; R6 = halo, phenoxy, alkoxy or NR7R8; R7, R8 = H, guanyl, cycloalkyl or alkyl (optionally substituted by phenyl, itself optionally substituted by 1-3 alkoxy) or 5-6 membered saturated heterocycle containing 1 or more N or one N plus one O; or NR7R8 = oxo-pyrrolidinyl, phthalimido (optionally substituted) or saturated 5-6 membered heterocycle containing one or more N or one N plus one O (optionally substituted by 1-3 of OH, phenyl (optionally substituted by 1-3 halo or alkoxy), phenoxy (optionally substituted by 1-3 halo or alkoxy) or phenoxyalkyl (optionally ring-substituted as for phenoxy and/or substituted in the alkyl by 1 or 2 OH); p = 0-2; R2 = NO2, NH2 or (1-4C) alkanoylamino; alkyl moieties have 1-4C and cycloalkyl 3-6C.
HU9701383A 1997-08-12 1997-08-12 New 8-methyl-7h-1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them HUP9701383A3 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
HU9701383A HUP9701383A3 (en) 1997-08-12 1997-08-12 New 8-methyl-7h-1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them
SK179-2000A SK1792000A3 (en) 1997-08-12 1998-08-07 1,3-DIOXOLO(4,5-H)(2,3)BENZODIAZEPINE DERIVATIVES, PROCESS FORì (54) THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION CO
AT98939782T ATE255112T1 (en) 1997-08-12 1998-08-07 1-3 DIOXOLO/4.5-H//2,3-BENZODIAZEPINE DERIVATIVES AS AMPA/KAINATE RECEPTOR INHIBITORS
NZ503301A NZ503301A (en) 1997-08-12 1998-08-07 1,3-dioxolo[4,5-h][2,3]benzodiazepine derivatives useful as AMPA/Kainate receptor inhibitors
EP98939782A EP1015457B1 (en) 1997-08-12 1998-08-07 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
PCT/HU1998/000076 WO1999007708A1 (en) 1997-08-12 1998-08-07 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
CA002300142A CA2300142A1 (en) 1997-08-12 1998-08-07 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
BR9812119-7A BR9812119A (en) 1997-08-12 1998-08-07 1,3-dioxolo / 4,5-h // 2,3 / benzodiazepine derivatives, process for their preparation and pharmaceutical composition
KR1020007001458A KR20010022856A (en) 1997-08-12 1998-08-07 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
PL98338681A PL338681A1 (en) 1997-08-12 1998-08-07 Derivatives of 1,3-dioxolo/4,5-h/2,3-benzodiazepins as inhibitors of ampa/cainate receptors
AU88182/98A AU748801B2 (en) 1997-08-12 1998-08-07 1,3-dioxolo/4,5-H//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
JP2000506211A JP2001512731A (en) 1997-08-12 1998-08-07 1,3-Dioxolo / 4,5-H / 2,3 / benzodiazepine derivatives as AMPA / Kainate receptor inhibitors
CN98809317A CN1271360A (en) 1997-08-12 1998-08-07 1,3-dioxolo/4,5-Hl/2,3/benzodiazepine derivatives as AMPA/Kainate receptor inhibitors
DE69820081T DE69820081D1 (en) 1997-08-12 1998-08-07 1-3 DIOXOLO / 4.5-H // 2,3-BENZODIAZEPINE DERIVATIVES AS AMPA / KAINATE RECEPTOR INHIBITORS
RU2000106061/04A RU2208014C2 (en) 1997-08-12 1998-08-07 Derivatives of 1,3-dioxol[4,5-h][2,3]benzodiazepine as inhibitors of ampa/kainate receptor, method for their preparing, pharmaceutical composition based on thereof and method of treatment
NO20000654A NO20000654L (en) 1997-08-12 2000-02-09 1,3-dioxolo / 4.5-H / 2.3 / Benzodiazepine derivatives as AMPA / kain receptor inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9701383A HUP9701383A3 (en) 1997-08-12 1997-08-12 New 8-methyl-7h-1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them

Publications (3)

Publication Number Publication Date
HU9701383D0 HU9701383D0 (en) 1997-10-28
HUP9701383A2 true HUP9701383A2 (en) 1999-06-28
HUP9701383A3 HUP9701383A3 (en) 2000-01-28

Family

ID=89995502

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701383A HUP9701383A3 (en) 1997-08-12 1997-08-12 New 8-methyl-7h-1,3-dioxolo[4,5-h][2,3]-benzodiazepine derivatives, pharmaceutical compositions containing them as active component, and process for producing them

Country Status (1)

Country Link
HU (1) HUP9701383A3 (en)

Also Published As

Publication number Publication date
HUP9701383A3 (en) 2000-01-28
HU9701383D0 (en) 1997-10-28

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