HUP9700566A1 - Amino-alkyl- and acyl-amino-alkyl-ethers, process for producing them and their use as bradiquinine-receptor-antagonists - Google Patents

Amino-alkyl- and acyl-amino-alkyl-ethers, process for producing them and their use as bradiquinine-receptor-antagonists

Info

Publication number
HUP9700566A1
HUP9700566A1 HU9700566A HUP9700566A HUP9700566A1 HU P9700566 A1 HUP9700566 A1 HU P9700566A1 HU 9700566 A HU9700566 A HU 9700566A HU P9700566 A HUP9700566 A HU P9700566A HU P9700566 A1 HUP9700566 A1 HU P9700566A1
Authority
HU
Hungary
Prior art keywords
alkyl
amino
hydrogen
acyl
ethers
Prior art date
Application number
HU9700566A
Other languages
Hungarian (hu)
Inventor
Holger Heitsch
Gerhard Nölken
Bernward Schölkens
Adalbert Wagner
Klaus Wirth
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Publication of HU9700566D0 publication Critical patent/HU9700566D0/en
Publication of HUP9700566A1 publication Critical patent/HUP9700566A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

Atalálmány az (I) általánős képletű - ahől R1, R2, R3jelentése alkil-, aril-, alkil-aril-csőpőrt, halőgén- vagyhidrőgénatőm, ciklőalkilcsőpőrt, CHO, -CO-O-alkil, COOH; R4, R5jelentése hidrőgén- vagy halőgénatőm, alkőxi-, nitrő-, cianő-,S-alkil-csőpőrt; R6 jelentése hidrőgénatőm, alkil-, alkil-alkenil-, alkil-aril-csőpőrt; R7 jelentése hidrőgénatőm vagy adőtt esetben szűbsztitűáltacilcsőpőrt; n értéke 1-8-, aminő-alkil- és acil-aminő-alkil-éterekrevőnatkőzik. A találmány szerinti vegyületek kiemelkedőbradikininreceptőr-antagőnista hatással és megnövelt vízőldékőnysággalrendelkeznek. A találmány tővábbá az (I) általánős képletű vegyületekelőállítására és az ezeket tartalmazó gyógyszerkészítményekre isvőnatkőzik. ŕThe invention has the general formula (I) - where R1, R2, R3 are alkyl, aryl, alkyl-aryl, halogen or hydrogen, cyclic alkyl, CHO, -CO-O-alkyl, COOH; R4, R5 is a hydrogen or halogen atom, alkyloxy, nitro, cyano, S-alkyl; R6 is hydrogen, alkyl, alkylalkenyl, alkylaryl; R7 represents a hydrogen atom or optionally a substituted alkyl group; The value of n depends on 1-8-, amino-alkyl- and acyl-amino-alkyl ethers. The compounds according to the invention have an outstanding bradykinin receptor antagonist effect and increased water solubility. The invention further relates to the production of compounds of general formula (I) and pharmaceutical preparations containing them. ŕ

HU9700566A 1996-03-13 1997-03-11 Amino-alkyl- and acyl-amino-alkyl-ethers, process for producing them and their use as bradiquinine-receptor-antagonists HUP9700566A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19609827A DE19609827A1 (en) 1996-03-13 1996-03-13 Aminoalkyl and acylaminoalkyl ethers, processes for their preparation and their use as bradykinin receptor antagonists

Publications (2)

Publication Number Publication Date
HU9700566D0 HU9700566D0 (en) 1997-04-28
HUP9700566A1 true HUP9700566A1 (en) 2000-08-28

Family

ID=7788139

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700566A HUP9700566A1 (en) 1996-03-13 1997-03-11 Amino-alkyl- and acyl-amino-alkyl-ethers, process for producing them and their use as bradiquinine-receptor-antagonists

Country Status (26)

Country Link
US (1) US6140341A (en)
EP (1) EP0795547B1 (en)
JP (1) JP4317597B2 (en)
KR (1) KR970065521A (en)
AR (1) AR006189A1 (en)
AT (1) ATE192738T1 (en)
AU (1) AU1621797A (en)
BR (1) BR9701267A (en)
CA (1) CA2199771A1 (en)
CZ (1) CZ76697A3 (en)
DE (2) DE19609827A1 (en)
DK (1) DK0795547T3 (en)
ES (1) ES2148858T3 (en)
GR (1) GR3033415T3 (en)
HR (1) HRP970138A2 (en)
HU (1) HUP9700566A1 (en)
ID (1) ID16217A (en)
IL (1) IL120427A0 (en)
NO (1) NO971136L (en)
PL (1) PL318923A1 (en)
PT (1) PT795547E (en)
SI (1) SI0795547T1 (en)
SK (1) SK32097A3 (en)
TR (1) TR199700184A2 (en)
TW (1) TW363891B (en)
ZA (1) ZA972129B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
HUP0003364A3 (en) 1997-06-19 2002-03-28 Sepracor Inc Marlborough Quinoline-indole antimicrobial agents, uses and compositions related thereto
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (en) * 2002-06-07 2003-12-09 Menarini Ricerche Spa NON-PEPTID BASIC ANTAGONISTS OF BRADICHININE AND THEIR USE PHARMACEUTICAL INFORMATION
TWI407960B (en) 2007-03-23 2013-09-11 Jerini Ag Small molecule bradykinin b2 receptor modulators
TWI446904B (en) 2007-11-01 2014-08-01 Acucela Inc Amine derivative compounds for treating ophthalmic diseases and disorders
SG11202004653TA (en) 2017-11-24 2020-06-29 Pharvaris Netherlands B V Novel bradykinin b2 receptor antagonists
AR118983A1 (en) 2019-05-23 2021-11-17 Pharvaris Gmbh CYCLIC BRADYKININ RECEPTOR ANTAGONISTS
AR118982A1 (en) 2019-05-23 2021-11-17 Pharvaris Gmbh CYCLIC BRADYKININ RECEPTOR ANTAGONISTS
AU2022323749A1 (en) 2021-08-05 2024-02-08 Pharvaris Gmbh Lipid-based composition for oral administration of bradykinin b2-receptor antagonists
TW202345810A (en) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 Solid extended-release composition comprising bradykinin b2-receptor antagonists
WO2023180575A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Solid composition comprising solubilised bradykinin b2-receptor antagonists
WO2023180577A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Therapeutic uses of bradykinin b2-receptor antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
US5288725A (en) * 1992-10-15 1994-02-22 Merck & Co., Inc. Pyrroloquinoline Bradykinin antagonist
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
AU705883B2 (en) * 1994-10-27 1999-06-03 Fujisawa Pharmaceutical Co., Ltd. Pyridopyrimidones, quinolines and fused N-heretocycles as bradykinin antagonists
FR2735128B1 (en) * 1995-06-07 1997-07-25 Fournier Ind & Sante NOVEL BENZENESULFONAMIDE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USE.
FR2737892B1 (en) * 1995-08-17 1997-10-24 Fournier Ind & Sante NOVEL BENZENESULFONAMIDE COMPOUNDS, PREPARATION METHOD AND THERAPEUTIC USE

Also Published As

Publication number Publication date
DK0795547T3 (en) 2000-09-18
JP4317597B2 (en) 2009-08-19
DE19609827A1 (en) 1997-09-18
PT795547E (en) 2000-10-31
NO971136L (en) 1997-09-15
EP0795547A1 (en) 1997-09-17
TW363891B (en) 1999-07-11
ES2148858T3 (en) 2000-10-16
HRP970138A2 (en) 1998-04-30
IL120427A0 (en) 1997-07-13
TR199700184A2 (en) 1997-10-21
CA2199771A1 (en) 1997-09-13
CZ76697A3 (en) 1997-10-15
HU9700566D0 (en) 1997-04-28
ATE192738T1 (en) 2000-05-15
PL318923A1 (en) 1997-09-15
SI0795547T1 (en) 2000-10-31
AR006189A1 (en) 1999-08-11
US6140341A (en) 2000-10-31
AU1621797A (en) 1997-09-18
MX9701857A (en) 1997-09-30
ZA972129B (en) 1997-09-15
BR9701267A (en) 1999-01-12
SK32097A3 (en) 1998-01-14
JPH101472A (en) 1998-01-06
DE59701617D1 (en) 2000-06-15
ID16217A (en) 1997-09-11
NO971136D0 (en) 1997-03-12
GR3033415T3 (en) 2000-09-29
KR970065521A (en) 1997-10-13
EP0795547B1 (en) 2000-05-10

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