KR830003466A - 1-benzocepin-5 (2H) -one derivatives and methods for preparing these salts - Google Patents

Abstract

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Description

1-benzosepin-5 (2H) -one derivatives and methods for preparing these salts.

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Claims (4)

The acid addition salts of the above-mentioned derivatives of the following formula (II) or the following formula (IV) are reacted with the amine of the following formula (III) in the present active solvent and then A / 3-amino-1 of the following formula (I) -Benzosepin-5 (2H) -one derivatives and their acid addition salts. In the above structural formula R ₁ and R ₂ are each a hydrogen atom, a C ₁ -C ₅ -alkyl group optionally substituted with an unsubstituted phenyl group or one or two halogen atoms or a methyl or methoxy group or 3,4-methylenedioxy or 3,4- A C ₂ -C ₅ -alkyl or C ₃ -C ₄ -alkenyl group optionally terminated with a phenyl group, a hydroxyl group or a methoxy group substituted with a methylenedioxy group, or _one of R ₁ and R ₂ is a hydrogen atom or C ₁ -C ₅ - alkyl group and the other is -NR ₅ R ₆ group to the terminal-substituted C ₂ -C ₅ - alkyl group, at the R ₅ and R ₆ are each a hydrogen atom or a C ₁ -C ₅ - alkyl group, or R ₅ and R ₆ is directly connected to the other or via a heteroatom selected from oxygen, sulfur and nitrogen to form a 5-angle to 7-angle ring containing nitrogen atoms, or R ₁ and R ₂ are directly connected to the other or Alkyl linked via a heteroatom selected from oxygen, sulfur and nitrogen-R ₇ It may be a ethylene group and forms a 5-angle to 7-angle ring containing a nitrogen atom, wherein R ₇ is a hydrogen atom or a methyl-benzyl or phenyl group: R ₃ and R ₄ are each a hydrogen atom, a halogen atom or a C ₁ -group. C ₄ -alkyl, C ₁ -C ₄ -alkoxy or C ₁ -C ₄ -alkylthio group, or one of R ₃ and R ₄ is a trifluoromethyl group or nitro group and the other is a hydrogen atom: and X is chlorine Or a cancellation atom. The process as claimed in claim 1, wherein the derivative of formula (I) is recovered in the form of an acid addition salt which is continuously converted to the free base. The process as claimed in claim 1, wherein the derivative of formula (I) is recovered in the form of a free base which is subsequently converted to an acid addition salt by reaction with an inorganic or organic acid. The compound of formula (V) is reacted in the presence of an inert solvent at a boiling point temperature of -70 ° C. to a solvent with a strong base selected from lithium hydride, sodium hydride and lithium tert-butylate. A method for producing a 3,4,5-tetrahydro-1-benzocepin-3,5-dione derivative. In the above structural formula R ₃ and R ₄ are defined in claim 1 and R ₈ is a straight or cyclic C ₁ -C ₆ alkyl group. ※ Note: The disclosure is based on the initial application.