HUP0500617A2 - Eljárások szabálytalan sejtproliferációval járó rendellenességekkel összefüggő polipeptid-antigének azonosítására, valamint készítmények ilyen rendellenességek kezelésére - Google Patents
Eljárások szabálytalan sejtproliferációval járó rendellenességekkel összefüggő polipeptid-antigének azonosítására, valamint készítmények ilyen rendellenességek kezeléséreInfo
- Publication number
- HUP0500617A2 HUP0500617A2 HU0500617A HUP0500617A HUP0500617A2 HU P0500617 A2 HUP0500617 A2 HU P0500617A2 HU 0500617 A HU0500617 A HU 0500617A HU P0500617 A HUP0500617 A HU P0500617A HU P0500617 A2 HUP0500617 A2 HU P0500617A2
- Authority
- HU
- Hungary
- Prior art keywords
- methods
- disorders
- mitosis
- cancerous cells
- polypeptide antigens
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 230000001594 aberrant effect Effects 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 230000011278 mitosis Effects 0.000 abstract 4
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 abstract 3
- 230000004540 complement-dependent cytotoxicity Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 231100000433 cytotoxic Toxicity 0.000 abstract 2
- 230000001472 cytotoxic effect Effects 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány tárgyát eljárások és készítmények képezik hatékonyrákterápiák kifejlesztésére mitózisgátlók alkalmazásával, melymitózisgátlók a normális, nem rákos sejtekre és szövetekre korlátozottmértékben fejtenek ki általános toxicitást. A találmány szerintieljárásokban és készítményekben citotoxikus vegyületeket alkalmaznak,amelyek mitózisgátló vegyülethez (pl. maytansinoidhoz) konjugáltsejtkötő ágensből (pl. antitestből) állnak. A találmány tárgyátképezik továbbá olyan antitestek, amelyek lényegében nem képesekantitest-dependens sejtközvetítette citotoxicitást (ADCC) vagykomplementdependens citotoxicitást (CDC) indukálni, ami biztosítja,hogy a terápiás hatást elsősorban a citotoxikus vegyület mitózisgátlókomponense, s nem az ADCC- és/vagy CDC-reakció által közvetítettindirekt sejthalál. A találmány szerinti antitestek képesekmegkülönböztetni azon polipeptid-antigéneket, amelyek a proliferálódórákos sejteken nagyobb mennyiségben expresszálódnak, mint aproliferálódó nem rákos sejteken.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31750401P | 2001-09-05 | 2001-09-05 | |
| PCT/US2002/028176 WO2003020909A2 (en) | 2001-09-05 | 2002-09-04 | Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0500617A2 true HUP0500617A2 (hu) | 2005-10-28 |
| HUP0500617A3 HUP0500617A3 (en) | 2012-05-02 |
Family
ID=23233944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500617A HUP0500617A3 (en) | 2001-09-05 | 2002-09-04 | Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1432446B1 (hu) |
| JP (2) | JP5224632B2 (hu) |
| KR (3) | KR20100061863A (hu) |
| CN (2) | CN101446590A (hu) |
| AT (1) | ATE506965T1 (hu) |
| AU (1) | AU2002332838B2 (hu) |
| BR (1) | BR0212641A (hu) |
| CA (1) | CA2457541C (hu) |
| DE (1) | DE60239881D1 (hu) |
| DK (1) | DK1432446T3 (hu) |
| HU (1) | HUP0500617A3 (hu) |
| IL (2) | IL160659A0 (hu) |
| MX (1) | MXPA04002084A (hu) |
| NZ (1) | NZ531515A (hu) |
| PL (1) | PL374363A1 (hu) |
| WO (1) | WO2003020909A2 (hu) |
| ZA (1) | ZA200401751B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8088387B2 (en) * | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| BRPI0410748B8 (pt) * | 2003-05-20 | 2021-05-25 | Immunogen Inc | compostos de maitansinóides, suas composições farmacêuticas, métodos de esterificação de maitansinóides, bem como métodos para a sua produção, e conjugado de maitansinóide-agente de ligação celular |
| CN101087611B (zh) * | 2003-10-10 | 2019-04-23 | 伊缪诺金公司 | 用经不可切割接头连接的细胞结合剂美登木素生物碱偶联物靶向特定细胞群的方法、所述偶联物和制备所述偶联物的方法 |
| EP2247304B1 (en) * | 2008-04-02 | 2016-05-25 | MacroGenics, Inc. | Her2/neu-specific antibodies and methods of using same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2026147C (en) * | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| DE60020529T2 (de) * | 1999-03-01 | 2006-04-27 | Genentech Inc., San Francisco | Antikörper zur krebsbehandlung und -diagnose |
| EP1226177B1 (en) * | 1999-10-29 | 2008-07-09 | Genentech, Inc. | Anti-prostate stem cell antigen (psca) antibody compositions and methods of use |
| WO2001055720A2 (en) * | 2000-01-26 | 2001-08-02 | Ventana Medical Systems, Inc. | A system for developing assays for personalized medicine |
-
2002
- 2002-09-04 DK DK02797854.3T patent/DK1432446T3/da active
- 2002-09-04 WO PCT/US2002/028176 patent/WO2003020909A2/en active Application Filing
- 2002-09-04 EP EP02797854A patent/EP1432446B1/en not_active Expired - Lifetime
- 2002-09-04 IL IL16065902A patent/IL160659A0/xx unknown
- 2002-09-04 JP JP2003525613A patent/JP5224632B2/ja not_active Expired - Fee Related
- 2002-09-04 AU AU2002332838A patent/AU2002332838B2/en not_active Ceased
- 2002-09-04 PL PL02374363A patent/PL374363A1/xx not_active IP Right Cessation
- 2002-09-04 NZ NZ531515A patent/NZ531515A/en not_active IP Right Cessation
- 2002-09-04 KR KR1020107011044A patent/KR20100061863A/ko not_active Application Discontinuation
- 2002-09-04 HU HU0500617A patent/HUP0500617A3/hu unknown
- 2002-09-04 MX MXPA04002084A patent/MXPA04002084A/es active IP Right Grant
- 2002-09-04 KR KR10-2004-7003327A patent/KR20040044850A/ko not_active Application Discontinuation
- 2002-09-04 AT AT02797854T patent/ATE506965T1/de not_active IP Right Cessation
- 2002-09-04 KR KR1020097019746A patent/KR20090104925A/ko not_active Application Discontinuation
- 2002-09-04 BR BR0212641-9A patent/BR0212641A/pt active Pending
- 2002-09-04 DE DE60239881T patent/DE60239881D1/de not_active Expired - Lifetime
- 2002-09-04 CN CNA2008101656506A patent/CN101446590A/zh active Pending
- 2002-09-04 CN CNA02821529XA patent/CN1578673A/zh active Pending
- 2002-09-04 CA CA2457541A patent/CA2457541C/en not_active Expired - Fee Related
-
2004
- 2004-03-01 IL IL160659A patent/IL160659A/en not_active IP Right Cessation
- 2004-03-03 ZA ZA2004/01751A patent/ZA200401751B/en unknown
-
2010
- 2010-08-04 JP JP2010175090A patent/JP2010280691A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1432446B1 (en) | 2011-04-27 |
| IL160659A0 (en) | 2004-08-31 |
| AU2002332838B2 (en) | 2007-08-02 |
| ZA200401751B (en) | 2005-07-27 |
| CN101446590A (zh) | 2009-06-03 |
| BR0212641A (pt) | 2005-04-12 |
| EP1432446A4 (en) | 2004-09-08 |
| EP1432446A2 (en) | 2004-06-30 |
| ATE506965T1 (de) | 2011-05-15 |
| CA2457541A1 (en) | 2003-03-13 |
| DK1432446T3 (da) | 2011-07-18 |
| PL374363A1 (en) | 2005-10-17 |
| MXPA04002084A (es) | 2004-06-07 |
| WO2003020909A3 (en) | 2003-11-20 |
| HUP0500617A3 (en) | 2012-05-02 |
| JP5224632B2 (ja) | 2013-07-03 |
| JP2010280691A (ja) | 2010-12-16 |
| JP2005517155A (ja) | 2005-06-09 |
| CN1578673A (zh) | 2005-02-09 |
| KR20040044850A (ko) | 2004-05-31 |
| KR20090104925A (ko) | 2009-10-06 |
| DE60239881D1 (de) | 2011-06-09 |
| NZ531515A (en) | 2007-11-30 |
| KR20100061863A (ko) | 2010-06-09 |
| WO2003020909A2 (en) | 2003-03-13 |
| IL160659A (en) | 2011-07-31 |
| CA2457541C (en) | 2013-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1575509A4 (en) | EPHA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHOD OF USE THEREOF | |
| PL1896507T3 (pl) | Przeciwciała monoklonalne anty-CD71 i ich zastosowanie do leczenia złośliwych komórek nowotworowych | |
| WO2020236817A8 (en) | Mcl-1 inhibitor antibody-drug conjugates and methods of use | |
| ATE365562T1 (de) | Zielgerichtete kombinations-immuntherapie für krebs | |
| WO2004032828A3 (en) | Anti-cd20 antibody-drug conjugates for the treatment of cancer and immune disorders | |
| WO2004018000A3 (en) | Compositions and methods for treating cancer using maytansinoid cd44 antibody immonoconjugates and chemotherapeutic agents | |
| SI2269656T1 (sl) | Izbrana protitelesa, ki se veĹľejo na aminofosfolipide, in njihova uporaba v zdravljanju raka | |
| MY136095A (en) | Use of human anti-ctla-4 antibodies for treatment of cancer | |
| EP2399935A3 (en) | An anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof | |
| EA200301159A1 (ru) | Цитотоксические иммуноконъюгаты антитела к cd44 | |
| IL176007A0 (en) | Antibodies specific to c35 and pharmaceutical compositions containing the same | |
| WO2008091620A3 (en) | Combination therapy comprising romidepsin and i.a. bortezomib | |
| WO2005049082A3 (en) | Chimeric anti cd44 antibodies and their use for treating acute myeloid leukemia | |
| CA2093667A1 (en) | Mouse monoclonal antibodies and uses thereof | |
| IL153680A0 (en) | Aplidine derivatives and methods for the preparation thereof | |
| WO2006088464A3 (en) | A method of using an anti-cd137 antibody as an agent for radioimmunotherapy or radioimmunodetection | |
| HUP0500617A2 (hu) | Eljárások szabálytalan sejtproliferációval járó rendellenességekkel összefüggő polipeptid-antigének azonosítására, valamint készítmények ilyen rendellenességek kezelésére | |
| MX2022013393A (es) | Receptores de antígenos quiméricos dirigidos a cd19 y uso de los mismos. | |
| AU2001233917A1 (en) | Bcmp-7 as marker for diagnosis of breast cancer | |
| BR0008305A (pt) | Utilização de uma proteìna ompa de enterobactéria, ou de um de seus fragmentos e composição farmacêutica | |
| JP2016511257A (ja) | 癌の治療における抗ｇｃｃ抗体−薬物複合体及びｄｎａ損傷剤の投与 | |
| WO2002026730A3 (en) | Fluorinated quinolones as antimitotic and antitumor agents | |
| AU2003293665A1 (en) | Compositions and methods for treating cancer using cytotoxic cd44 antibody immunoconjugates and radiotherapy | |
| MXPA02008014A (es) | Composiciones inhibidoras de tumores de 1-nitroacridina. | |
| WO2004064748A3 (en) | Compositions and methods for treatment of ovarian cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |