HUP0402643A2 - 3,4-Dihidro-1H-izokinolin-2-il-származékok, eljárás az előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
3,4-Dihidro-1H-izokinolin-2-il-származékok, eljárás az előállításukra és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0402643A2 HUP0402643A2 HU0402643A HUP0402643A HUP0402643A2 HU P0402643 A2 HUP0402643 A2 HU P0402643A2 HU 0402643 A HU0402643 A HU 0402643A HU P0402643 A HUP0402643 A HU P0402643A HU P0402643 A2 HUP0402643 A2 HU P0402643A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- aryl
- cycloalkyl
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 3,4-dihydro-1H-isoquinolin-2-yl Chemical class 0.000 abstract 15
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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Abstract
A találmány az új (I) általános képletű 3,4-dihidro-1H-izokinolin-2-il-származékokra, ezek gyógyászatilag elfogadható sóira és ilyenvegyületeket tartalmazó, NK2 antagonista hatású gyógyászatikészítményekre vonatkozik. Az (I) általános képletben R1 jelentéseR11CO-, R11CS-, R11SO2-, R11OCO-, R11SCO- vagy R11CO-CR12R13_ csoport,mimellett R11 jelentése alkil-, alkenil-, alkinil-, cikloalkil-,cikloalkilalkil-, aril-, aralkil-, heteroaril-, heteroaralkil-,tetrahidropiranil-, 1,2,3,4-tetrahidronaftalenil vagy halogénatommaladott esetben szubsztituált 4H-benzo[1,3]dioxinilcsoport, továbbá azemlített alkil-, aril-, heteroaril- és cikloalkilcsoportok mindegyikegymástól függetlenül adott esetben helyettesítve lehet, továbbá R12és R13 egymástól függetlenül hidrogénatomot vagy alkilcsoportotjelent; vagy R1 jelenté e R14R15NCO- vagy R14R15NCS- csoport,mimeIlett R14 és R15 egymástól függetlenül hidrogénatomot vagy alkil-,alkenil-, alkinil-, cikloalkil-, cikloalkilalkil-, aril- vagyaralkilcsoportot jelentenek, és az említett alkil-, aril- éscikloalkilcsoportok mindegyike adott esetben szubsztituálva lehet,vagy pedig R14 és Rl5 egytitt pirrolidinil-, piperidinil- vagyperhidroazepinilcsoportot alkotnak azzal a nitrogénatommal, amelyhezkapcsolódnak; R2 jelentése hidrogénatom, trifluormetilcsoport vagyalkilcsoport; R3-R6, R7a, R7b, R8a és R8b egymástól függetlenülhidrogén- vagy halogénatomot vagy ciano-, nitro-, alkil-, alkenil-,alkinil-, cikloalkil-, cikloalkilalkil-, amino-, alkilamino-,dialkilamino-, alkilkarbonil-, aminokarbonil-, alkilaminokarbonil-,dialkilaminokarbonil-, alkoxi-, alkiltio-, hidroxi-, trifluormetil-,trifluormetilszulfonil- vagy alkilszulfonilcsoportot jelent; m értéke2, 3, 4, 5 vagy 6; R9 jelentése bexizil-, benzoil-, 2,3-dihidrobenzofuranil- vagy mono- vagy biciklusos aril vagyheteroarilcsoport, mimellett az említett benzil-, benzoil-, aril- ésheteroarilcsoportok mindegyike adott esetben szubsztituálva lehet; Qjelentése szén- vagy nitrogénatom vagy CR10 általános képletű csoport;R10 jelentése hidrogén- vagy halogénatom vagy ciano-, nitro-, alkil-,alkenil-, alkinil-, cikloalkil-, cikloalkilalkil-, amino-,alkilamino-, dialkilamino-, alkilkarbonil-, aminokarbonil-,alkilaminokarbonil-, dialkilaminokarbonil-, alkoxi-, alkiltio-,hidroxi-, trifluormetil-, difluormetil-, fluormetil- vagytrifluormetilszulfonilcsoport, -NR30COR31 általános képletű csoport(ebben a képletben R30 hidrogénatomot vagy alkilcsoportot és R31alkilcsoportot jelent), -COOR16 általános képletű csoport (ebben aképletben R16 jelentése hidrogénatom vagy alkilcsoport) vagy -CONR17R18 általános képletű csoport (ebben a képletben R17 és R18egymástól függetlenül hidrogénatomot vagy alkilcsoportot jelent vagyR17 és R18 azzal a nitrogénatommal, amelyhez k
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34190501P | 2001-12-19 | 2001-12-19 | |
| DKPA200101916 | 2001-12-19 | ||
| PCT/DK2002/000858 WO2003051869A1 (en) | 2001-12-19 | 2002-12-16 | 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0402643A2 true HUP0402643A2 (hu) | 2005-04-28 |
Family
ID=26069113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402643A HUP0402643A2 (hu) | 2001-12-19 | 2002-12-16 | 3,4-Dihidro-1H-izokinolin-2-il-származékok, eljárás az előállításukra és az ezeket tartalmazó gyógyszerkészítmények |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7384957B2 (hu) |
| EP (1) | EP1458714A1 (hu) |
| JP (1) | JP2005518378A (hu) |
| CN (1) | CN100509805C (hu) |
| AU (1) | AU2002351733A1 (hu) |
| CA (1) | CA2470723A1 (hu) |
| EA (1) | EA006082B1 (hu) |
| HU (1) | HUP0402643A2 (hu) |
| IL (1) | IL162310A0 (hu) |
| MX (1) | MXPA04005988A (hu) |
| NO (1) | NO20042980L (hu) |
| NZ (1) | NZ533358A (hu) |
| WO (1) | WO2003051869A1 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7834008B2 (en) | 2003-08-15 | 2010-11-16 | H. Lundbeck A/S | Cyclopropyl derivatives as NK3 receptor antagonists |
| CN1867549B (zh) * | 2003-08-15 | 2011-07-06 | H·隆德贝克有限公司 | 作为nk3受体拮抗剂的环丙基衍生物 |
| MX2007002033A (es) * | 2004-08-19 | 2007-04-26 | Vertex Pharma | Moduladores de receptores muscarinicos. |
| EP1994019B1 (en) * | 2005-04-30 | 2011-11-02 | Boehringer Ingelheim International GmbH | Novel piperidin - substituted indoles and their use as ccr-3 modulators |
| AU2007221220A1 (en) * | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Spiro condensed piperidnes as modulators of muscarinic receptors |
| CN102884059B (zh) * | 2010-03-11 | 2015-08-26 | 大日本住友制药株式会社 | N-酰基环胺衍生物或其可药用盐 |
| JP5715605B2 (ja) * | 2011-09-14 | 2015-05-07 | 大日本住友製薬株式会社 | Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬 |
| CN105315267B (zh) * | 2014-07-30 | 2019-06-04 | 江苏恩华药业股份有限公司 | 一种酰胺类衍生物及其应用 |
| SI3204359T1 (sl) * | 2014-10-08 | 2020-10-30 | UCB Biopharma SRL | Tetrahidroizokinolinski derivati |
| EA036137B1 (ru) * | 2016-04-13 | 2020-10-02 | Юсб Байофарма Спрл | Производные тетрагидроизохинолина |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994891A (en) * | 1974-12-20 | 1976-11-30 | Armour Pharmaceutical Company | Tetrahydroisoquinoline compounds |
| DE3827727A1 (de) | 1988-08-16 | 1990-02-22 | Boehringer Ingelheim Kg | Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion |
| DE4104257A1 (de) * | 1991-02-13 | 1992-08-20 | Boehringer Ingelheim Kg | Verwendung von anellierten tetrahydropyridinessigsaeurederivaten fuer die behandlung neurologischer erkrankungen |
| DK0736012T3 (da) * | 1993-12-21 | 2001-01-29 | Boehringer Ingelheim Pharma | Anellerede dihydropyridiner og deres anvendelse til fremstilling af farmaceutiske præparater |
| TW458978B (en) * | 1995-11-07 | 2001-10-11 | Astra Ab | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
-
2002
- 2002-12-16 CA CA002470723A patent/CA2470723A1/en not_active Abandoned
- 2002-12-16 IL IL16231002A patent/IL162310A0/xx unknown
- 2002-12-16 HU HU0402643A patent/HUP0402643A2/hu unknown
- 2002-12-16 MX MXPA04005988A patent/MXPA04005988A/es unknown
- 2002-12-16 CN CNB028281527A patent/CN100509805C/zh not_active Expired - Fee Related
- 2002-12-16 AU AU2002351733A patent/AU2002351733A1/en not_active Abandoned
- 2002-12-16 WO PCT/DK2002/000858 patent/WO2003051869A1/en active Application Filing
- 2002-12-16 EP EP02787450A patent/EP1458714A1/en not_active Withdrawn
- 2002-12-16 US US10/499,880 patent/US7384957B2/en not_active Expired - Fee Related
- 2002-12-16 NZ NZ533358A patent/NZ533358A/xx unknown
- 2002-12-16 EA EA200400822A patent/EA006082B1/ru not_active IP Right Cessation
- 2002-12-16 JP JP2003552753A patent/JP2005518378A/ja active Pending
-
2004
- 2004-07-14 NO NO20042980A patent/NO20042980L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20050070713A1 (en) | 2005-03-31 |
| EA006082B1 (ru) | 2005-08-25 |
| CN100509805C (zh) | 2009-07-08 |
| CA2470723A1 (en) | 2003-06-26 |
| IL162310A0 (en) | 2005-11-20 |
| EP1458714A1 (en) | 2004-09-22 |
| AU2002351733A1 (en) | 2003-06-30 |
| US7384957B2 (en) | 2008-06-10 |
| JP2005518378A (ja) | 2005-06-23 |
| NO20042980L (no) | 2004-07-14 |
| EA200400822A1 (ru) | 2004-12-30 |
| WO2003051869A1 (en) | 2003-06-26 |
| CN1620452A (zh) | 2005-05-25 |
| NZ533358A (en) | 2007-05-31 |
| MXPA04005988A (es) | 2004-09-27 |
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Legal Events
| Date | Code | Title | Description |
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| FD9A | Lapse of provisional protection due to non-payment of fees |