HUP0402549A2 - Parenterális paracetamol készítmény - Google Patents
Parenterális paracetamol készítményInfo
- Publication number
- HUP0402549A2 HUP0402549A2 HU0402549A HUP0402549A HUP0402549A2 HU P0402549 A2 HUP0402549 A2 HU P0402549A2 HU 0402549 A HU0402549 A HU 0402549A HU P0402549 A HUP0402549 A HU P0402549A HU P0402549 A2 HUP0402549 A2 HU P0402549A2
- Authority
- HU
- Hungary
- Prior art keywords
- additional
- disodium
- active pharmaceutical
- synthetic
- paracetamol
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229960005489 paracetamol Drugs 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 abstract 1
- BCXHDORHMMZBBZ-DORFAMGDSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;sulfuric acid Chemical compound OS(O)(=O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC BCXHDORHMMZBBZ-DORFAMGDSA-N 0.000 abstract 1
- BVDRUCCQKHGCRX-UHFFFAOYSA-N 2,3-dihydroxypropyl formate Chemical compound OCC(O)COC=O BVDRUCCQKHGCRX-UHFFFAOYSA-N 0.000 abstract 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 abstract 1
- QPJVMBTYPHYUOC-UHFFFAOYSA-N Methyl benzoate Natural products COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- HOZOZZFCZRXYEK-GSWUYBTGSA-M butylscopolamine bromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CCCC)=CC=CC=C1 HOZOZZFCZRXYEK-GSWUYBTGSA-M 0.000 abstract 1
- 229960001948 caffeine Drugs 0.000 abstract 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 abstract 1
- OFZCIYFFPZCNJE-UHFFFAOYSA-N carisoprodol Chemical compound NC(=O)OCC(C)(CCC)COC(=O)NC(C)C OFZCIYFFPZCNJE-UHFFFAOYSA-N 0.000 abstract 1
- 229960004587 carisoprodol Drugs 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229960004415 codeine phosphate Drugs 0.000 abstract 1
- 229960003871 codeine sulfate Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000019262 disodium citrate Nutrition 0.000 abstract 1
- 239000002526 disodium citrate Substances 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- 229910000397 disodium phosphate Inorganic materials 0.000 abstract 1
- 235000019800 disodium phosphate Nutrition 0.000 abstract 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 1
- 229960001687 orphenadrine citrate Drugs 0.000 abstract 1
- MMMNTDFSPSQXJP-UHFFFAOYSA-N orphenadrine citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=C(C)C=1C(OCCN(C)C)C1=CC=CC=C1 MMMNTDFSPSQXJP-UHFFFAOYSA-N 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgya parenterálisan injektálható, stabil, gyógyszerkénthasználható oldat, amely a) egyedüli gyógyszer-hatóanyagként, vagypedig további vegyületekkel együtt, például egy vagy több továbbigyógyszer-hatóanyaggal, mint például hioszcin-N-butil-bromiddal,kodein-foszfáttal vagy kodein-szulfáttal, karizoprodollal, orfenadrin-citráttal, acetil-szalicilsavval, koffeinnel és/vagy valamelyszintetikus vagy félszintetikus morfinszármazékkal együttparacetamolt, b) egy glicerin-formált, valamely alkoholt, példáuletanolt, benzil-alkoholt vagy propilén-glikolt, valamint vizetmeghatározott térfogatarányban tartalmazó oldószerelegyet, és c) p-hidroxi-benzoesav-metil-észter és p-hidroxi-benzoesav-propil-észterantioxidánsoknak keverékét és/vagy további antioxidáns anyagokat, ezenkívül az oldat pH-jának 5 és 6,5 közé, előnyösen 5,5 és 6 közé; és mégelőnyösebben 5;5 és 5,6 közé való beállítása céljából dinátrium-foszfátot, nátrium-hidroxidot, nátrium-karbonátot és/vagy dinátrium-citrátot, továbbá kelátképző anyagként etilén-diamin-tetraecetsav-dinátriumsót tartalmaz.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GR2001/000047 WO2003051398A1 (en) | 2001-12-18 | 2001-12-18 | Parenteral composition of paracetamol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0402549A2 true HUP0402549A2 (hu) | 2005-10-28 |
| HUP0402549A3 HUP0402549A3 (en) | 2006-01-30 |
Family
ID=10927136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402549A HUP0402549A3 (en) | 2001-12-18 | 2001-12-18 | Parenteral composition of paracetamol |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050203175A1 (hu) |
| EP (1) | EP1469885A1 (hu) |
| CN (1) | CN1582170B (hu) |
| EA (1) | EA006939B1 (hu) |
| EE (1) | EE200400094A (hu) |
| HK (1) | HK1072001A1 (hu) |
| HR (1) | HRPK20040615B3 (hu) |
| HU (1) | HUP0402549A3 (hu) |
| ME (1) | ME00483B (hu) |
| RS (1) | RS53804A (hu) |
| SK (1) | SK2822004A3 (hu) |
| WO (1) | WO2003051398A1 (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006346318B2 (en) | 2006-07-18 | 2011-02-10 | Genfarma Laboratorio S.L. | Injectable liquid paracetamol formulation |
| AR067047A1 (es) * | 2007-06-18 | 2009-09-30 | Combino Pharm Sl | Formulaciones acuosas de acetaminofen para inyeccion. |
| WO2009098716A2 (en) * | 2008-01-17 | 2009-08-13 | Aptuit Laurus Private Limited | Stable pharmaceutical aqueous compositions |
| EP2243477A1 (de) * | 2009-04-22 | 2010-10-27 | Fresenius Kabi Deutschland GmbH | Paracetamol zur parenteralen Verabreichung |
| HUE027032T2 (hu) * | 2009-07-23 | 2016-08-29 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S A | Stabil, azonnal alkalmazható injektálható paracetamol készítmény |
| EP2308463A1 (en) * | 2009-10-12 | 2011-04-13 | EMP Pharma GmbH | Aqueous acetaminophen compositions and method of preparation |
| EP2377514A3 (en) * | 2010-04-19 | 2012-04-11 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | Liquid parenteral formulation comprising a tramadol material and paracetamol |
| BR112013023062B1 (pt) | 2011-03-10 | 2022-01-18 | Xeris Pharmaceuticals, Inc | Solução estável para a injeção parenteral e método de fabricação da mesma |
| SG11201401921YA (en) | 2011-10-31 | 2014-05-29 | Xeris Pharmaceuticals Inc | Formulations for the treatment of diabetes |
| US9125805B2 (en) | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
| ITMI20121154A1 (it) * | 2012-06-29 | 2013-12-30 | Sint Sa | Soluzione iniettabile di acetaminofene per la somministrazione spinale |
| US9018162B2 (en) | 2013-02-06 | 2015-04-28 | Xeris Pharmaceuticals, Inc. | Methods for rapidly treating severe hypoglycemia |
| CN106573106B (zh) | 2014-08-06 | 2021-06-22 | Xeris药物公司 | 用于皮内和/或皮下注射糊剂的注射器、试剂盒和方法 |
| US9649364B2 (en) | 2015-09-25 | 2017-05-16 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic formulations in aprotic polar solvents |
| US11590205B2 (en) | 2015-09-25 | 2023-02-28 | Xeris Pharmaceuticals, Inc. | Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents |
| KR20240036128A (ko) | 2017-06-02 | 2024-03-19 | 엑스에리스 파머수티클스, 인크. | 침전 방지 저분자 약물 제제 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2454424C3 (de) * | 1974-11-16 | 1978-10-12 | Messerschmitt-Boelkow-Blohm Gmbh, 8000 Muenchen | Schaltung für einen elektronischen Sensor zur Auslösung einer Sicherheitsvorrichtung |
| GB2058562B (en) * | 1979-09-14 | 1983-11-30 | Beecham Group Ltd | Pharmaceutical compositions containing paracetamol and ascorbic acid |
| EP0620001A1 (en) * | 1993-04-16 | 1994-10-19 | McNEIL-PPC, INC. | Aqueous pharmaceutical suspension and process for preparation thereof |
| US5510389A (en) * | 1994-03-02 | 1996-04-23 | The Procter & Gamble Company | Concentrated acetaminophen solution compositions |
| US5502056A (en) * | 1994-05-27 | 1996-03-26 | Breitbarth; Richard | Caffeine containing composition |
| US5662353A (en) * | 1995-12-06 | 1997-09-02 | Trw Vehicle Safety Systems Inc. | Electrical conductor for air bag inflator |
| FR2751875B1 (fr) * | 1996-08-05 | 1998-12-24 | Scr Newpharm | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
| DE59712694D1 (de) * | 1997-04-18 | 2006-08-24 | Fritz Stanislaus | Stabilisiertes arzneimittel enthaltend cysteinylderivate |
| DK1285667T3 (da) * | 1997-11-18 | 2006-09-11 | Uni Pharma Kleon Tsetis Pharmaceutical Lab Sa | Farmaceutisk injicerbar oplösning af paracetamol og kombinationer af paracetamol med andre aktive bestanddele |
| US7157103B2 (en) * | 2001-08-06 | 2007-01-02 | Euro-Celtique S.A. | Pharmaceutical formulation containing irritant |
| EP2218443B1 (en) * | 2007-11-21 | 2014-03-26 | Dainippon Sumitomo Pharma Co., Ltd. | Orally disintegrating tablet |
| US9072799B2 (en) * | 2008-10-31 | 2015-07-07 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
-
2001
- 2001-12-18 EP EP01274999A patent/EP1469885A1/en not_active Ceased
- 2001-12-18 ME MEP-2008-762A patent/ME00483B/me unknown
- 2001-12-18 US US10/498,878 patent/US20050203175A1/en not_active Abandoned
- 2001-12-18 HU HU0402549A patent/HUP0402549A3/hu not_active Application Discontinuation
- 2001-12-18 SK SK282-2004A patent/SK2822004A3/sk not_active Application Discontinuation
- 2001-12-18 EE EEP200400094A patent/EE200400094A/xx unknown
- 2001-12-18 WO PCT/GR2001/000047 patent/WO2003051398A1/en active Application Filing
- 2001-12-18 EA EA200400819A patent/EA006939B1/ru not_active IP Right Cessation
- 2001-12-18 CN CN018239285A patent/CN1582170B/zh not_active Expired - Fee Related
- 2001-12-18 RS YU53804A patent/RS53804A/sr unknown
-
2004
- 2004-07-06 HR HR20040615A patent/HRPK20040615B3/xx not_active IP Right Cessation
-
2005
- 2005-06-08 HK HK05104820.3A patent/HK1072001A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003051398A8 (en) | 2004-07-22 |
| ME00483B (me) | 2011-10-10 |
| HUP0402549A3 (en) | 2006-01-30 |
| US20050203175A1 (en) | 2005-09-15 |
| SK2822004A3 (sk) | 2005-01-03 |
| EE200400094A (et) | 2004-08-16 |
| EP1469885A1 (en) | 2004-10-27 |
| EA006939B1 (ru) | 2006-06-30 |
| WO2003051398A1 (en) | 2003-06-26 |
| EA200400819A1 (ru) | 2004-12-30 |
| HRPK20040615B3 (en) | 2005-10-31 |
| HRP20040615A2 (en) | 2004-12-31 |
| RS53804A (en) | 2006-12-15 |
| CN1582170B (zh) | 2010-05-05 |
| HK1072001A1 (en) | 2005-08-12 |
| CN1582170A (zh) | 2005-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0402549A2 (hu) | Parenterális paracetamol készítmény | |
| UY27320A1 (es) | Nuevas composiciones farmacéuticas | |
| NZ330369A (en) | aqueous medicaments containing 9-hydroxy-risperidone fatty acid ester | |
| ES2091441T3 (es) | Composicion farmaceutica. | |
| NO20062019L (no) | P-glykoproteininhibitor, fremgangsmater for fremstilling av denne samt farmasoytiske preparater inneholdende den samme | |
| ATE386508T1 (de) | Feste orale dosierungsform enthaltend einen resorptionsverstärker | |
| RU2695274C3 (ru) | Новые композиции и способы их стабилизации | |
| BRPI0415121A (pt) | material particulado, forma de dosagem sólida, método para fabricar a mesma, e, uso de um material particulado ou de uma forma de dosagem sólida | |
| FI931031A0 (fi) | Mometasonfuroatmonohydrat, foerfarande foer dess framstaellning och farmaceutiska sammansaettningar | |
| MY101536A (en) | Anti-inflammatory and analgesic tape for external use | |
| EA199700201A1 (ru) | Парентеральные фармацевтические композиции, содержащие алкиламмониевые соли 2-арилпропиновых кислот | |
| MY130857A (en) | Pharmaceutical preparations for external use containing non-steroidal anti-inflammatory and analgesic agents | |
| MX167912B (es) | Metodo para la produccion de una preparacion de nicorandil estable | |
| PE20011223A1 (es) | Composicion farmaceutica que comprende pemetrexed y un antioxidante como monotioglicerol, l-cisteina y acido tioglicolico | |
| TW225536B (hu) | ||
| EA199801028A1 (ru) | Применение производных п-аминофенола для проготовления фармацевтических композиций, используемых при лечении нейродегенеративных заболеваний | |
| KR890006644A (ko) | 결정성 β-락탐 수화물 | |
| NZ331083A (en) | Pharmaceutical preparations of cilansetron stabilized against racemization | |
| KR900001675A (ko) | 기관지확장 작용을 갖는 화합물 | |
| ES2174388T3 (es) | Solucion liquida de medicamento para administracion oral. | |
| AP1530A (en) | Pharmaceutical composition for intramuscular injection containing loxoprofen. | |
| ATE14437T1 (de) | Aminoglycosid-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und solche derivate zur verwendung als arzneimittel. | |
| JPS57156418A (en) | Carcinostatic | |
| JPS57158719A (en) | Rectal administration pharmaceutical | |
| NZ505080A (en) | Pharmaceutical formulations containing a compound having an amidine group stabilized by an acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC4A | Lapse of provisional application due to refusal |