HUP0401371A2 - LTB4 antagonistát tartalmazó gyógyszerforma és eljárás az előállítására - Google Patents
LTB4 antagonistát tartalmazó gyógyszerforma és eljárás az előállításáraInfo
- Publication number
- HUP0401371A2 HUP0401371A2 HU0401371A HUP0401371A HUP0401371A2 HU P0401371 A2 HUP0401371 A2 HU P0401371A2 HU 0401371 A HU0401371 A HU 0401371A HU P0401371 A HUP0401371 A HU P0401371A HU P0401371 A2 HUP0401371 A2 HU P0401371A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- alkyl
- preparation
- phe
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000002615 leukotriene B4 derivatives Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005002 aryl methyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 150000002338 glycosides Chemical class 0.000 abstract 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 abstract 1
- -1 oxyxylyleneoxy Chemical group 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány tárgyát olyan tablettaformájú gyógyszerkészítmény,előállítása és alkalmazása képezi, amely hatóanyagként egy általánosképletű LTB4 antagonistát - ahol A -O-CmH2m-O-(PHE)n- általánosképletű csoport, ahol m = 2-6; n = 0 vagy 1 és PHE = adott esetbenszubsztituált p-feniléncsoport; vagy oxi-xililén-oxicsoport; R1 H, -OH, -CN, -CHO és -CORl0 vagy -COOR10 általános képletű csoport; R2 H,Br, C1, F, CHF2-, CF3-, -OH, HSO3-O-, alkil-, alkoxi-, cikloalkil-,aril-, aril-oxi-, aril-metilcsoport, -CONR8R9, -CR5R6-aril vagy -C(CH3)2-R7 általános képletű csoport; R3 H, C1, F, -OH, alkil- vagyalkoxicsoport; R4 H vagy alkilcsoport - vagy gyógyszerészetilegelfogadható savaddíciós sóit, glikozidjait és O-szulfátjait, valamintlegalább egy betegségek kezelésére vagy megelőzésére alkalmasgyógyszerkészítmény előállítására elfogadható segédanyagot és legalábbegy nedvesítőszert tartalmaz. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10134377 | 2001-07-14 | ||
| DE10206241A DE10206241A1 (de) | 2001-07-14 | 2002-02-15 | Arzneimittelformulierung enthaldend einen LTB Antagonisten |
| PCT/EP2002/007618 WO2003007922A2 (de) | 2001-07-14 | 2002-07-09 | Arzneimittelformulierung enthaltend einen ltb4 antagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401371A2 true HUP0401371A2 (hu) | 2004-12-28 |
| HUP0401371A3 HUP0401371A3 (en) | 2010-01-28 |
Family
ID=26009704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401371A HUP0401371A3 (en) | 2001-07-14 | 2002-07-09 | Pharmaceutical formulation containing an ltb4 antagonist and process for its preparation |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1408943B1 (hu) |
| JP (1) | JP2005502630A (hu) |
| KR (1) | KR100912196B1 (hu) |
| CN (1) | CN1298316C (hu) |
| AT (1) | ATE298564T1 (hu) |
| AU (1) | AU2002333235B2 (hu) |
| BR (1) | BR0211090A (hu) |
| CA (1) | CA2452357A1 (hu) |
| ES (1) | ES2244821T3 (hu) |
| HU (1) | HUP0401371A3 (hu) |
| IL (1) | IL159493A0 (hu) |
| MX (1) | MXPA04000384A (hu) |
| NZ (1) | NZ530973A (hu) |
| PL (1) | PL368613A1 (hu) |
| RU (1) | RU2004102399A (hu) |
| UY (1) | UY27376A1 (hu) |
| WO (1) | WO2003007922A2 (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10232120A1 (de) | 2002-07-16 | 2004-02-05 | Fev Motorentechnik Gmbh | Verfahren und Vorrichtung zum künstlichen Altern eines Kraftfahrzeugkatalysators |
| RS20050390A (en) * | 2002-11-26 | 2008-04-04 | Boehringer Ingelheim Pharma Gmbh. & Co.Kg., | Pharmaceutical composition comprising a ltb4 antagonist and a cox-2 inhibitor or a combined cox 1/2 inhibitor |
| EP1750669A1 (en) * | 2004-05-04 | 2007-02-14 | Boehringer Ingelheim International Gmbh | Solid pharmaceutical form comprising an ltb4 antagonist |
| JP7373191B2 (ja) | 2017-05-12 | 2023-11-02 | 国立研究開発法人理化学研究所 | クラスａ ｇｐｃｒ結合性化合物改変体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| AU673343B2 (en) * | 1992-02-05 | 1996-11-07 | Boehringer Ingelheim International Gmbh | Novel amidine derivatives, their preparation and their use as mediaments with LTB4 antagonistic effect |
| DE4424713A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
| DE19546452A1 (de) * | 1995-12-13 | 1997-06-19 | Boehringer Ingelheim Kg | Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel |
| DE19636689A1 (de) * | 1996-09-10 | 1998-03-12 | Boehringer Ingelheim Kg | Neue Benzamidinderivate |
| DE19637123A1 (de) * | 1996-09-12 | 1998-03-19 | Boehringer Ingelheim Kg | Neue Pyranosidderivate |
| DE19948428A1 (de) * | 1999-10-07 | 2001-04-12 | Boehringer Ingelheim Pharma | Neuer LTB¶4¶-Antagonist, Verfahren zu dessen Herstellung und dessen Verwendung als Arzneimittel |
-
2002
- 2002-07-09 BR BR0211090-3A patent/BR0211090A/pt not_active Expired - Fee Related
- 2002-07-09 RU RU2004102399/15A patent/RU2004102399A/ru not_active Application Discontinuation
- 2002-07-09 IL IL15949302A patent/IL159493A0/xx unknown
- 2002-07-09 CN CNB028139763A patent/CN1298316C/zh not_active Expired - Fee Related
- 2002-07-09 HU HU0401371A patent/HUP0401371A3/hu unknown
- 2002-07-09 AU AU2002333235A patent/AU2002333235B2/en not_active Ceased
- 2002-07-09 JP JP2003513531A patent/JP2005502630A/ja active Pending
- 2002-07-09 MX MXPA04000384A patent/MXPA04000384A/es active IP Right Grant
- 2002-07-09 CA CA002452357A patent/CA2452357A1/en not_active Abandoned
- 2002-07-09 WO PCT/EP2002/007618 patent/WO2003007922A2/de active IP Right Grant
- 2002-07-09 PL PL02368613A patent/PL368613A1/xx not_active Application Discontinuation
- 2002-07-09 AT AT02787119T patent/ATE298564T1/de not_active IP Right Cessation
- 2002-07-09 ES ES02787119T patent/ES2244821T3/es not_active Expired - Lifetime
- 2002-07-09 NZ NZ530973A patent/NZ530973A/en unknown
- 2002-07-09 KR KR1020047000585A patent/KR100912196B1/ko not_active IP Right Cessation
- 2002-07-09 EP EP02787119A patent/EP1408943B1/de not_active Expired - Lifetime
- 2002-07-11 UY UY27376A patent/UY27376A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1298316C (zh) | 2007-02-07 |
| ES2244821T3 (es) | 2005-12-16 |
| AU2002333235B2 (en) | 2007-07-12 |
| RU2004102399A (ru) | 2005-05-27 |
| IL159493A0 (en) | 2004-06-01 |
| MXPA04000384A (es) | 2004-05-04 |
| JP2005502630A (ja) | 2005-01-27 |
| UY27376A1 (es) | 2003-02-28 |
| EP1408943A2 (de) | 2004-04-21 |
| WO2003007922A3 (de) | 2003-04-17 |
| PL368613A1 (en) | 2005-04-04 |
| HUP0401371A3 (en) | 2010-01-28 |
| ATE298564T1 (de) | 2005-07-15 |
| BR0211090A (pt) | 2004-06-15 |
| WO2003007922A2 (de) | 2003-01-30 |
| CN1527705A (zh) | 2004-09-08 |
| KR20040016988A (ko) | 2004-02-25 |
| KR100912196B1 (ko) | 2009-08-14 |
| NZ530973A (en) | 2006-07-28 |
| CA2452357A1 (en) | 2003-01-30 |
| EP1408943B1 (de) | 2005-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |