HUP0303656A3 - Modulators of bruton's tyrosine kinase, their identification and use - Google Patents

Modulators of bruton's tyrosine kinase, their identification and use

Info

Publication number
HUP0303656A3
HUP0303656A3 HU0303656A HUP0303656A HUP0303656A3 HU P0303656 A3 HUP0303656 A3 HU P0303656A3 HU 0303656 A HU0303656 A HU 0303656A HU P0303656 A HUP0303656 A HU P0303656A HU P0303656 A3 HUP0303656 A3 HU P0303656A3
Authority
HU
Hungary
Prior art keywords
bruton
modulators
identification
tyrosine kinase
tyrosine
Prior art date
Application number
HU0303656A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of HUP0303656A2 publication Critical patent/HUP0303656A2/hu
Publication of HUP0303656A3 publication Critical patent/HUP0303656A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
HU0303656A 2000-10-23 2001-10-22 Modulators of bruton's tyrosine kinase, their identification and use HUP0303656A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24247100P 2000-10-23 2000-10-23
PCT/US2001/051415 WO2002038797A2 (en) 2000-10-23 2001-10-22 Modulators of bruton's tyrosine kinase, their identification and use

Publications (2)

Publication Number Publication Date
HUP0303656A2 HUP0303656A2 (hu) 2004-03-01
HUP0303656A3 true HUP0303656A3 (en) 2006-03-28

Family

ID=22914900

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303656A HUP0303656A3 (en) 2000-10-23 2001-10-22 Modulators of bruton's tyrosine kinase, their identification and use

Country Status (7)

Country Link
US (1) US20030040461A1 (hu)
EP (1) EP1373554A2 (hu)
JP (1) JP2004533209A (hu)
AU (1) AU2002236692A1 (hu)
CA (1) CA2426508A1 (hu)
HU (1) HUP0303656A3 (hu)
WO (1) WO2002038797A2 (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090118139A1 (en) * 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
EP2322201A3 (en) * 2002-10-29 2011-07-27 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
DE10331202A1 (de) 2003-07-10 2005-03-31 S.K. Enterprise Gmbh Verwendung von Molkenpermeat zur Behandlung des Metabolischen Syndroms
CN101421269A (zh) * 2006-01-13 2009-04-29 环状药物公司 酪氨酸激酶抑制剂及其用途
DE102006036285A1 (de) * 2006-08-03 2008-02-07 "S.U.K." Beteiligungs Gmbh Fraktionen aus Molkepermeat und deren Verwendung zur Prävention und Therapie des Typ-2 Diabetes und des Metabolischen Syndroms
JP2010502751A (ja) * 2006-09-11 2010-01-28 シージーアイ ファーマシューティカルズ，インコーポレイティド キナーゼ阻害物質、およびキナーゼ阻害物質の使用および同定方法
EP2532235A1 (en) 2006-09-22 2012-12-12 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
WO2008077022A2 (en) * 2006-12-18 2008-06-26 The Johns Hopkins University Himf and btk in pulmonary, cardiac, and inflammation disorders
CA2680589A1 (en) 2007-03-14 2008-09-18 Universita' Degli Studi Di Milano - Bicocca Modulator compounds of the drug resistance in epithelial tumour cells
US8809273B2 (en) 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
US20090301928A1 (en) * 2008-06-05 2009-12-10 United Comb & Novelty Corporation Packaging For Lipped Containers
MX2011000661A (es) 2008-07-16 2011-05-25 Pharmacyclics Inc Inhibidores de tirosina cinasa de bruton para el tratamiento de tumores solidos.
CA3240281A1 (en) 2010-06-03 2011-12-08 Pharmacyclics Llc Use of inhibitors of bruton's tyrosine kinase (btk) in the treatment of follicular lymphoma
KR20140058543A (ko) 2011-07-08 2014-05-14 노파르티스 아게 신규 피롤로 피리미딘 유도체
EP2731612A4 (en) 2011-07-13 2015-04-08 Pharmacyclics Inc BRUTON TYROSINE KINASE HEMMER
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
CN104736178A (zh) 2012-06-04 2015-06-24 药品循环公司 布鲁顿酪氨酸激酶抑制剂的晶形
EP2877598A1 (en) 2012-07-24 2015-06-03 Pharmacyclics, Inc. Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
SG11201503842PA (en) 2012-11-15 2015-06-29 Pharmacyclics Inc Pyrrolopyrimidine compounds as kinase inhibitors
TWI649081B (zh) 2013-08-02 2019-02-01 製藥公司 治療固態腫瘤之方法
CA2920534A1 (en) 2013-08-12 2015-02-19 Pharmacyclics Llc Methods for the treatment of her2 amplified cancer
EP3052486A1 (en) 2013-09-30 2016-08-10 Pharmacyclics LLC Inhibitors of bruton's tyrosine kinase
KR102357526B1 (ko) 2013-10-25 2022-02-04 파마싸이클릭스 엘엘씨 이식편 대 숙주 질환의 치료 및 예방 방법
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
CA2942528A1 (en) 2014-03-20 2015-09-24 Pharmacyclics Inc. Phospholipase c gamma 2 and resistance associated mutations
AU2015296215A1 (en) 2014-08-01 2017-03-23 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
MX2017001671A (es) 2014-08-07 2017-07-04 Pharmacyclics Llc Formulaciones novedosas de un inhibidor de la tirosina cinasa de bruton.
IL315294A (en) 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of proton tyrosine kinase inhibitor
US11118233B2 (en) 2016-05-18 2021-09-14 The University Of Chicago BTK mutation and ibrutinib resistance

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968304A1 (en) * 1997-02-11 2000-01-05 Merck & Co., Inc. Identification of inhibitors of protein tyrosine kinase 2
JP2002501757A (ja) * 1998-01-29 2002-01-22 メルク エンド カムパニー インコーポレーテッド ストレス応答性キナーゼのモジュレーターの特定方法
DE69918089T2 (de) * 1998-04-17 2005-07-14 Parker Hughes Institute, St. Paul Btk inhibitoren und verfahren zur identifizierung und verwendung
US6306897B1 (en) * 1999-03-19 2001-10-23 Parker Hughes Institute Calanolides for inhibiting BTK
GB0025804D0 (en) * 2000-10-20 2000-12-06 Glaxo Group Ltd Assay

Also Published As

Publication number Publication date
CA2426508A1 (en) 2002-05-16
EP1373554A2 (en) 2004-01-02
JP2004533209A (ja) 2004-11-04
AU2002236692A1 (en) 2002-05-21
WO2002038797A2 (en) 2002-05-16
US20030040461A1 (en) 2003-02-27
HUP0303656A2 (hu) 2004-03-01
WO2002038797A3 (en) 2003-10-09

Similar Documents

Publication Publication Date Title
HUP0303656A3 (en) Modulators of bruton's tyrosine kinase, their identification and use
US5919813C1 (en) Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
IL178864A0 (en) 3'-prodrugs of 2'-deoxy-??-l-nucleosides
HUP0402113A3 (en) 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity, preparation and use thereof
AU2002359123A8 (en) Benzodiazepine derivatives, preparation thereof and use thereof
IL159067A0 (en) METHODS FOR PREPARATION AND USE OF 1alpha,24 (S) -DIHYDROXYVITAMIN D2
HUP0202048A2 (en) Use of alpha1betha1 integrin receptor inhibitors and tgf-betha1 inhibitors in the treatment of kidney disease
IL135150A0 (en) A method and a system for secured identification of user's identity
HK1047548A1 (zh) 包含有米氮平和哲比隆的治療抑鬱症及其它機能紊亂症的合成藥物
HK1042504A1 (en) Human cervical cancer 1 protooncogene and protein encoded therein
AU2001247008A1 (en) Variants of the human amp-activated protein kinase gamma 3 subunit
AU2001263492A1 (en) 21956 and 25856, human aminopeptidases and uses thereof
EP1317271A4 (en) THERAPEUTIC AND COSMETIC USES OF HEPARANASES
AU2001263287A1 (en) Human protein kinase "13305" and uses therefor
GB0005495D0 (en) Issuing and distribution of tokens
IL151493A0 (en) Use of dermaciclane for the treatment of anxiety and depression
AU5719501A (en) Novel human kinase proteins and polynucleotides encoding the same
AU2001296780A1 (en) 48120, 23479, and 46689, novel human hydrolases and uses thereof
IL154297A0 (en) Glycoproteins, their preparation and use
AU2002225852A1 (en) "67118", "67067" and "62092", human proteins and methods of use thereof
AU2002245158A1 (en) Human proteins 55562 and 21617, and methods of use thereof
AU2888399A (en) Identification and expression of human kir5.1
HK1060358A1 (en) Derivatives of cyano-aryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines, their preparation and application
Rosenwinkel et al. The enemies of energy
AU2002228882A1 (en) 58569 and 50111, human anion exchange proteins and methods of use thereof

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees