HUP0303437A2 - Fenil-származékok, eljárás az előállításukra és ezek tromboemboliás elváltozások vagy tumorok kezelésénél való alkalmazása és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Fenil-származékok, eljárás az előállításukra és ezek tromboemboliás elváltozások vagy tumorok kezelésénél való alkalmazása és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0303437A2
HUP0303437A2 HU0303437A HUP0303437A HUP0303437A2 HU P0303437 A2 HUP0303437 A2 HU P0303437A2 HU 0303437 A HU0303437 A HU 0303437A HU P0303437 A HUP0303437 A HU P0303437A HU P0303437 A2 HUP0303437 A2 HU P0303437A2
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Hungary
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unsubstituted
atoms
trisubstituted
mono
het
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HU0303437A
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English (en)
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Christopher Barnes
Bertram Cezanne
Dieter Dorsch
Johannes Gleitz
Horst Juraszyk
Werner Mederski
Christos Tsaklakidis
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Merck Patent Gmbh.
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Publication of HUP0303437A2 publication Critical patent/HUP0303437A2/hu

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Abstract

A találmány tárgya (I) általános képletű vegyületek,gyógyszerészetileg elfogadható származékai, szolvátjai éssztereoizomerjei és ezek bármilyen arányú keveréke - a képletben R1jelentése CN vagy -C(=NH)-NH2, CON(R3)2 vagy -[C(R4)2]nN(R3)2 csoport,amelyek mindegyike szubsztituálatlan vagy monoszubsztituált vagy egy(a) vagy (b) képletű csoport R2 jelentése H, Hal, A, OR3, N(R3)2, NO2,CN, COOR3, CON(R3)2, -[C(R4)2]n-Ar, -[C(R4)2]n-Het vagy -[C(R4)2]n-cikloalkil-, R3 jelentése H, A, -[C(R4)2]n-Ar, -[C(R4)2]n-Het vagy -[C(R4)2]n-cikloalkil-, R4 jelentése H vagy A, W jelentése -NR3CO-, -NR3COC(R4)2, NR3C(R4)2 vagy -C(R4)2NR3C(R4)2-, X jelentése -C(R3)2-, -[C(R3)2]2-, -C(R3)2O- vagy -C(R3)2NR3 Y jelentése alkilén-,cikloalkilén-, Het-diil- vagy Ar-diil-csoport, T jelentése OR3,N(R3)2, N(R3)2CON(R3)2, egy monociklusos vagy biciklusos, telített,telítetlen vagy aromás heterociklusos csoport, amely 1-4 N, O és/vagyS atomot tartalmaz és amely szubsztituálatlan vagy mono-, di- vagytriszubsztituált, vagy fenilcsoport, amely szubsztituálatlan vagymono-, di- vagy triszubsztituált, A jelentése egyenes vagy elágazóláncú 1-6 szénatomos alkilcsoport, amelyben egy vagy két CH2 csoport Ovagy S atommal és/vagy -CH=CH- csoporttal helyettesítve lehet és/vagytovábbá 1-7 hidrogénatom fluoratommal helyettesítve lehet, Arjelentése fenil-, naftil- vagy bifenilcsoport, amelyek mindegyikeszubsztituálatlan vagy mono-, di- vagy triszubsztituált, Het jelentésemonociklusos vagy biciklusos, telített, telítetlen vagy aromásheterociklusos csoport, amely 1-4 N-, O- és/vagy S-atomot tartalmaz ésamely szubsztituálatlan vagy mono-, di- vagy triszubsztituált, Haljelentése F, Cl, Br vagy I, m és n értéke egymástól függetlenül 0, 1vagy 2. A találmány oltalmi körébe tartoznak továbbá a fenti (I)általános képletű vegyületeket hatóanyagként tartalmazógyógyszerkészítmények, amelyek adott esetben még további gyógyszer-hatóanyagot is tartalmazhatnak. Ó
HU0303437A 2001-03-03 2002-02-04 Fenil-származékok, eljárás az előállításukra és ezek tromboemboliás elváltozások vagy tumorok kezelésénél való alkalmazása és ezeket tartalmazó gyógyszerkészítmények HUP0303437A2 (hu)

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DE10110325A DE10110325A1 (de) 2001-03-03 2001-03-03 Phenylderivate 2
PCT/EP2002/001114 WO2002070471A1 (en) 2001-03-03 2002-02-04 Phenyl derivatives and their use in the treatment of thromboembolic disorders or tumours

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US (1) US20040092517A1 (hu)
EP (1) EP1370522A1 (hu)
JP (1) JP2004525119A (hu)
CN (1) CN1524072A (hu)
CA (1) CA2439644A1 (hu)
DE (1) DE10110325A1 (hu)
HU (1) HUP0303437A2 (hu)
MX (1) MXPA03007866A (hu)
WO (1) WO2002070471A1 (hu)
ZA (1) ZA200307715B (hu)

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EP1846411A4 (en) 2005-01-25 2010-08-04 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
CN104557656B (zh) * 2015-01-13 2016-06-01 佛山市赛维斯医药科技有限公司 含卤苯和二烯金刚烷结构的化合物、其制备方法和用途

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CA2439644A1 (en) 2002-09-12
ZA200307715B (en) 2005-01-03
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JP2004525119A (ja) 2004-08-19
WO2002070471A1 (en) 2002-09-12

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