HUP0302306A3 - Propionic acid derivatives with ppar-alpha activating properties - Google Patents
Propionic acid derivatives with ppar-alpha activating propertiesInfo
- Publication number
- HUP0302306A3 HUP0302306A3 HU0302306A HUP0302306A HUP0302306A3 HU P0302306 A3 HUP0302306 A3 HU P0302306A3 HU 0302306 A HU0302306 A HU 0302306A HU P0302306 A HUP0302306 A HU P0302306A HU P0302306 A3 HUP0302306 A3 HU P0302306A3
- Authority
- HU
- Hungary
- Prior art keywords
- ppar
- propionic acid
- acid derivatives
- activating properties
- alpha activating
- Prior art date
Links
- 230000003213 activating effect Effects 0.000 title 1
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 title 1
- 150000005599 propionic acid derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10049208 | 2000-10-05 | ||
| DE10124905A DE10124905A1 (de) | 2000-10-05 | 2001-05-22 | Propionsäurederivate |
| PCT/EP2001/011005 WO2002028821A2 (de) | 2000-10-05 | 2001-09-24 | Propionsäurederivate mit ppar-alpha aktivierenden eigenschaften. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302306A2 HUP0302306A2 (hu) | 2003-10-28 |
| HUP0302306A3 true HUP0302306A3 (en) | 2005-02-28 |
Family
ID=26007267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302306A HUP0302306A3 (en) | 2000-10-05 | 2001-09-24 | Propionic acid derivatives with ppar-alpha activating properties |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1328508A2 (no) |
| JP (1) | JP2004510757A (no) |
| CN (1) | CN1479716A (no) |
| AU (1) | AU2001293838A1 (no) |
| BG (1) | BG107684A (no) |
| BR (1) | BR0114437A (no) |
| CA (1) | CA2424540A1 (no) |
| CZ (1) | CZ2003964A3 (no) |
| EE (1) | EE200300140A (no) |
| HN (1) | HN2001000223A (no) |
| HR (1) | HRP20030346A2 (no) |
| HU (1) | HUP0302306A3 (no) |
| IL (1) | IL155125A0 (no) |
| MA (1) | MA25917A1 (no) |
| MX (1) | MXPA03002901A (no) |
| NO (1) | NO20031517L (no) |
| NZ (1) | NZ525119A (no) |
| PL (1) | PL361162A1 (no) |
| RU (1) | RU2003112968A (no) |
| SK (1) | SK4132003A3 (no) |
| UY (1) | UY26951A1 (no) |
| WO (1) | WO2002028821A2 (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10151390A1 (de) * | 2001-10-18 | 2003-05-08 | Bayer Ag | Essigsäurederivate |
| GB0214254D0 (en) * | 2002-06-20 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
| NZ539451A (en) * | 2002-10-21 | 2008-03-28 | Janssen Pharmaceutica Nv | Substituted tetralin and indane derivatives and their use in therapy |
| PL376325A1 (en) * | 2002-10-21 | 2005-12-27 | Janssen Pharmaceutica, N.V. | Substituted tetralins and indanes |
| NZ539432A (en) * | 2002-10-21 | 2008-04-30 | Janssen Pharmaceutica Nv | Treating syndrome X with substituted tetralins and indanes |
| US7504433B2 (en) | 2003-01-06 | 2009-03-17 | Eli Lilly And Company | Thiophene derivative PPAR modulators |
| ES2754221T3 (es) | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
| AR048931A1 (es) | 2004-04-21 | 2006-06-14 | Janssen Pharmaceutica Nv | Proceso para la preparacion de derivados de tetralina sustituida e indano sustituido y preparacion de intermediarios de sintesis |
| CN100344618C (zh) * | 2004-05-24 | 2007-10-24 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物 |
| KR100699928B1 (ko) * | 2004-10-05 | 2007-03-26 | 재단법인서울대학교산학협력재단 | 퍼록시솜 증식자 활성화 수용체 알파 리간드를 제조하기위한 중간체의 제조방법 |
| ATE541830T1 (de) | 2004-12-13 | 2012-02-15 | Ono Pharmaceutical Co | Aminocarbonsäurederivat und dessen medizinische verwendung |
| CN101054372B (zh) * | 2006-04-11 | 2010-10-13 | 中国科学院上海药物研究所 | 嘧啶取代苯丙酸衍生化合物、其制法和在治疗多囊肾疾病中的用途 |
| WO2010064633A1 (ja) | 2008-12-01 | 2010-06-10 | 田辺三菱製薬株式会社 | チアゾール環を含むカルボン酸誘導体およびその医薬用途 |
| JP5436941B2 (ja) * | 2009-06-03 | 2014-03-05 | あすか製薬株式会社 | ラクタム化合物又はその塩及びｐｐａｒ活性化剤 |
| UY34200A (es) | 2011-07-21 | 2013-02-28 | Bayer Ip Gmbh | 3-(fluorovinil)pirazoles y su uso |
| US10954272B2 (en) * | 2014-12-11 | 2021-03-23 | Centrient Pharmaceuticals Netherlands B.V. | Method for acylating a cyclic peptide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2320387A1 (de) * | 1973-04-21 | 1974-10-31 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeurederivate und verfahren zur herstellung derselben |
| GB9822473D0 (en) * | 1998-10-16 | 1998-12-09 | Glaxo Group Ltd | Chemical compounds |
-
2001
- 2001-09-24 IL IL15512501A patent/IL155125A0/xx unknown
- 2001-09-24 CN CNA018200885A patent/CN1479716A/zh active Pending
- 2001-09-24 NZ NZ525119A patent/NZ525119A/en unknown
- 2001-09-24 EP EP01974287A patent/EP1328508A2/de not_active Withdrawn
- 2001-09-24 WO PCT/EP2001/011005 patent/WO2002028821A2/de active IP Right Grant
- 2001-09-24 RU RU2003112968/04A patent/RU2003112968A/ru not_active Application Discontinuation
- 2001-09-24 BR BR0114437-5A patent/BR0114437A/pt not_active IP Right Cessation
- 2001-09-24 CA CA002424540A patent/CA2424540A1/en not_active Abandoned
- 2001-09-24 HU HU0302306A patent/HUP0302306A3/hu unknown
- 2001-09-24 CZ CZ2003964A patent/CZ2003964A3/cs unknown
- 2001-09-24 PL PL01361162A patent/PL361162A1/xx not_active Application Discontinuation
- 2001-09-24 EE EEP200300140A patent/EE200300140A/xx unknown
- 2001-09-24 AU AU2001293838A patent/AU2001293838A1/en not_active Abandoned
- 2001-09-24 SK SK413-2003A patent/SK4132003A3/sk not_active Application Discontinuation
- 2001-09-24 MX MXPA03002901A patent/MXPA03002901A/es unknown
- 2001-09-24 JP JP2002532408A patent/JP2004510757A/ja active Pending
- 2001-10-03 UY UY26951A patent/UY26951A1/es not_active Application Discontinuation
- 2001-10-04 HN HN2001000223A patent/HN2001000223A/es unknown
-
2003
- 2003-03-28 BG BG107684A patent/BG107684A/bg unknown
- 2003-04-03 NO NO20031517A patent/NO20031517L/no not_active Application Discontinuation
- 2003-04-04 MA MA27091A patent/MA25917A1/fr unknown
- 2003-05-02 HR HR20030346A patent/HRP20030346A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL155125A0 (en) | 2003-10-31 |
| SK4132003A3 (en) | 2004-02-03 |
| EE200300140A (et) | 2003-08-15 |
| CA2424540A1 (en) | 2003-04-02 |
| WO2002028821A2 (de) | 2002-04-11 |
| HN2001000223A (es) | 2001-10-25 |
| BR0114437A (pt) | 2003-07-01 |
| RU2003112968A (ru) | 2004-09-20 |
| NZ525119A (en) | 2005-04-29 |
| NO20031517L (no) | 2003-05-28 |
| CN1479716A (zh) | 2004-03-03 |
| WO2002028821A3 (de) | 2002-08-15 |
| MA25917A1 (fr) | 2003-10-01 |
| UY26951A1 (es) | 2002-06-20 |
| CZ2003964A3 (cs) | 2003-08-13 |
| MXPA03002901A (es) | 2003-10-15 |
| AU2001293838A1 (en) | 2002-04-15 |
| PL361162A1 (en) | 2004-09-20 |
| EP1328508A2 (de) | 2003-07-23 |
| HRP20030346A2 (en) | 2005-04-30 |
| HUP0302306A2 (hu) | 2003-10-28 |
| NO20031517D0 (no) | 2003-04-03 |
| JP2004510757A (ja) | 2004-04-08 |
| BG107684A (bg) | 2003-10-31 |
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