HUP0301957A2 - Karbaminsav-észterek mint Xa-faktor inhibitorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Karbaminsav-észterek mint Xa-faktor inhibitorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0301957A2
HUP0301957A2 HU0301957A HUP0301957A HUP0301957A2 HU P0301957 A2 HUP0301957 A2 HU P0301957A2 HU 0301957 A HU0301957 A HU 0301957A HU P0301957 A HUP0301957 A HU P0301957A HU P0301957 A2 HUP0301957 A2 HU P0301957A2
Authority
HU
Hungary
Prior art keywords
things
inhibitors
factor
pharmaceutical compositions
acid esters
Prior art date
Application number
HU0301957A
Other languages
English (en)
Inventor
Christopher Barnes
Dieter Dorsch
Johannes Gleitz
Horst Juraszyk
Werner Mederski
Christos Tsaklakidis
Original Assignee
Merck Patent Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh. filed Critical Merck Patent Gmbh.
Publication of HUP0301957A2 publication Critical patent/HUP0301957A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Confectionery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya (I) általános képletű vegyületek - ahol a képletbenR jelentése - egyebek mellett - CO-N=C(NH2)2-, NH-C(=NH)-NH2 vagyC(=NH)-NH2-csoport, R1 jelentése - egyebek mellett - egyenesláncú,elágazó vagy gyűrűs 1-20 szénatomot tartalmazó alkilcsoport, amelybenegy vagy két CH2-csoportot O- vagy S-atomok helyettesíthetnek, R2jelentése - egyebek mellett - fenilcsoport, és azok gyógyászatilagelfogadható sói és szolvátjai. A találmány tárgyát képezi továbbá atalálmány szerinti legalább egy gyógyszerhatóanyagot, kívánt esetbensegédanyagokat és/vagy kiegészítő anyagokat és kívánt esetben máshatóanyagokat tartalmazó gyógyászati készítmény és egy vagy többtalálmány szerinti vegyület és/vagy azok fiziológiailag elfogadhatósói alkalmazása betegségek leküzdésére szolgáló gyógyszerelőállítására. Ó
HU0301957A 2000-05-31 2001-04-10 Karbaminsav-észterek mint Xa-faktor inhibitorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények HUP0301957A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10027024A DE10027024A1 (de) 2000-05-31 2000-05-31 Carbaminsäureester
PCT/EP2001/004112 WO2001092214A1 (de) 2000-05-31 2001-04-10 Carbaminsäureester als inhibitoren des faktors xa

Publications (1)

Publication Number Publication Date
HUP0301957A2 true HUP0301957A2 (hu) 2003-11-28

Family

ID=7644254

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301957A HUP0301957A2 (hu) 2000-05-31 2001-04-10 Karbaminsav-észterek mint Xa-faktor inhibitorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Country Status (17)

Country Link
US (1) US20030199698A1 (hu)
EP (1) EP1289941A1 (hu)
JP (1) JP2003535074A (hu)
KR (1) KR20030007752A (hu)
AR (1) AR029931A1 (hu)
AU (1) AU2001260193A1 (hu)
BR (1) BR0111059A (hu)
CA (1) CA2410628A1 (hu)
CZ (1) CZ20023588A3 (hu)
DE (1) DE10027024A1 (hu)
HU (1) HUP0301957A2 (hu)
MX (1) MXPA02011801A (hu)
NO (1) NO20025740D0 (hu)
PL (1) PL358688A1 (hu)
SK (1) SK15522002A3 (hu)
WO (1) WO2001092214A1 (hu)
ZA (1) ZA200210301B (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200410921A (en) * 2002-11-25 2004-07-01 Hoffmann La Roche Mandelic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19530996A1 (de) * 1995-08-23 1997-02-27 Boehringer Mannheim Gmbh Cyclische Guanidine, Verfahren zu ihrer Herstellung und Arzneimittel
DE19755268A1 (de) * 1997-12-12 1999-06-17 Merck Patent Gmbh Benzamidinderivate
DE19819548A1 (de) * 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenylderivate

Also Published As

Publication number Publication date
AR029931A1 (es) 2003-07-23
WO2001092214A1 (de) 2001-12-06
NO20025740L (no) 2002-11-29
KR20030007752A (ko) 2003-01-23
PL358688A1 (en) 2004-08-09
SK15522002A3 (sk) 2003-03-04
DE10027024A1 (de) 2001-12-06
ZA200210301B (en) 2004-09-06
BR0111059A (pt) 2003-04-15
NO20025740D0 (no) 2002-11-29
EP1289941A1 (de) 2003-03-12
US20030199698A1 (en) 2003-10-23
CZ20023588A3 (cs) 2003-02-12
AU2001260193A1 (en) 2001-12-11
MXPA02011801A (es) 2003-04-10
JP2003535074A (ja) 2003-11-25
CA2410628A1 (en) 2002-11-28

Similar Documents

Publication Publication Date Title
NO20062051L (no) Farmasoytisk virkestoffinneholdende formulering med belegg
ATE424810T1 (de) Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung
HUP0302131A2 (hu) Gyógyászati tramadolsók, ezeket tartalmazó gyógyszerkészítmények
HUP0302571A2 (hu) Szerves vegyületek keverékét tartalmazó gyógyszerkészítmény légúti betegségek kezelésére
CY1109457T1 (el) Παραγωγο aminoαλκοολης ή παραγωγο φωσφονικου οξεος και φαρμακευτικη συνθεση που τα περιεχει
TNSN03110A1 (en) Azaindoles.
HK1076605A1 (en) Formulations
GEP20074208B (en) Substituted amides active at the cannabinoid-1 receptor
BR0213562A (pt) Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna
EA200700049A1 (ru) Препаративные формы оральных лекарственных форм мемантина с модифицированным высвобождением
CY1107850T1 (el) Παραγωγα θειαδιαζολυλοπιπεραζiνης mε χρησιμοτητα στην αποτροπη ή στην αγωγη εναντι tου αλγους
BR0317294A (pt) Composto, formulação farmacêutica, uso de um composto, métodos de prevenção e/ou tratamento de condições associadas com a glicogênio sintase quinase-3 e de prevenção e/ou tratamento de doenças, e, uso dos intermediários
EA200400007A1 (ru) ФАРМАЦЕВТИЧЕСКИЙ СОСТАВ ДЛЯ ЭФФЕКТИВНОГО ВВЕДЕНИЯ АПОМОРФИНА, 6aR-(-)-N-ПРОПИЛ-НОРАПОМОРФИНА, ИХ ПРОИЗВОДНЫХ И ИХ ПРОЛЕКАРСТВ
SE9901573D0 (sv) New compounds
HUP0100520A1 (hu) Csontfelszívódást és sejtösszenövést gátló új szulfonamidszármazékok
SG147450A1 (en) Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof
DE50203456D1 (de) Deuterierte 3-piperidinopropiophenone sowie diese verbindungen enthaltende arzneimittel
HUP0203844A2 (hu) Növekedési hormon kibocsátó tulajdonságú vegyület, ezt tartalmazó gyógyszerkészítmény és alkalmazása
HUP0100024A2 (hu) Alzheimer-kór kezelésére szolgáló hatóanyagként karvedilolszármazékokat tartalmazó gyógyszerkészítmények
SE0102440D0 (sv) New compound
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
TW200740440A (en) Novel combinations of medicaments for the treatment of respiratory diseases containing long-acting beta-agonists and at least one additional active ingredient
SE9901572D0 (sv) New compounds
DE602005017629D1 (de) Pharmazeutische zusammensetzungen zur behandlung von leishmaniasis
HUP0301957A2 (hu) Karbaminsav-észterek mint Xa-faktor inhibitorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények