HUP0203188A3 - Intermediates for making a benzofuran or benzothiophene derivative nitrated in position 5 and uses thereof - Google Patents
Intermediates for making a benzofuran or benzothiophene derivative nitrated in position 5 and uses thereofInfo
- Publication number
- HUP0203188A3 HUP0203188A3 HU0203188A HUP0203188A HUP0203188A3 HU P0203188 A3 HUP0203188 A3 HU P0203188A3 HU 0203188 A HU0203188 A HU 0203188A HU P0203188 A HUP0203188 A HU P0203188A HU P0203188 A3 HUP0203188 A3 HU P0203188A3
- Authority
- HU
- Hungary
- Prior art keywords
- nitrated
- benzofuran
- intermediates
- making
- benzothiophene derivative
- Prior art date
Links
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 2
- HQALDKFFRYFTKP-UHFFFAOYSA-N 2-[4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2-bromo-6-(3-methoxyphenyl)phenoxy]acetic acid Chemical compound COC1=CC=CC(C=2C(=C(Br)C=C(C=2)C=2C=CC(=CC=2)C=2C3=CC=CC=C3SC=2CC=2C=CC=CC=2)OCC(O)=O)=C1 HQALDKFFRYFTKP-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9913250A FR2800067B1 (fr) | 1999-10-21 | 1999-10-21 | Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations |
| PCT/FR2000/002937 WO2001028974A2 (fr) | 1999-10-21 | 2000-10-23 | Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0203188A2 HUP0203188A2 (hu) | 2003-03-28 |
| HUP0203188A3 true HUP0203188A3 (en) | 2003-04-28 |
Family
ID=9551278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0203188A HUP0203188A3 (en) | 1999-10-21 | 2000-10-23 | Intermediates for making a benzofuran or benzothiophene derivative nitrated in position 5 and uses thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6855842B1 (hu) |
| EP (1) | EP1222159B1 (hu) |
| JP (1) | JP2003512347A (hu) |
| CN (1) | CN1268601C (hu) |
| AT (1) | ATE296795T1 (hu) |
| AU (1) | AU1032401A (hu) |
| BR (1) | BR0014808A (hu) |
| CA (1) | CA2387713A1 (hu) |
| DE (1) | DE60020587T2 (hu) |
| DK (1) | DK1222159T3 (hu) |
| ES (1) | ES2239623T3 (hu) |
| FR (1) | FR2800067B1 (hu) |
| HU (1) | HUP0203188A3 (hu) |
| PT (1) | PT1222159E (hu) |
| WO (1) | WO2001028974A2 (hu) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60007164T2 (de) * | 1999-10-21 | 2004-09-16 | Rhodia Chimie | Verfahren zur herstellung von benzofuranen oder benzothiophenen |
| IL146389A0 (en) | 2001-11-08 | 2002-07-25 | Isp Finetech Ltd | Process for the preparation of dronedarone |
| DE10237819A1 (de) | 2002-08-19 | 2004-03-04 | Bayer Ag | 5-Nitrobenzofurane |
| UY32657A (es) | 2009-05-27 | 2010-12-31 | Sanofi Aventis | Procedimiento para la fabricación de productos intermedios de dronedarona |
| UY32656A (es) | 2009-05-27 | 2010-12-31 | Sanofi Aventis | Procedimiento para producir benzofuranos |
| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| WO2012032545A1 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Processes for preparing dronedarone and its intermediates |
| CN101948455B (zh) * | 2010-10-18 | 2012-11-14 | 山东邹平大展新材料有限公司 | 一种2-正丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃的制备方法 |
| WO2012120544A2 (en) | 2011-03-10 | 2012-09-13 | Sun Pharmaceutical Industries Ltd. | PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
| EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
| WO2013121235A2 (en) | 2012-02-13 | 2013-08-22 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| US9249119B2 (en) | 2012-02-14 | 2016-02-02 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| US9382223B2 (en) | 2012-02-22 | 2016-07-05 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| US9238636B2 (en) | 2012-05-31 | 2016-01-19 | Sanofi | Process for preparation of dronedarone by Grignard reaction |
| CN115847629B (zh) * | 2022-11-30 | 2023-09-29 | 江苏富乐徳石英科技有限公司 | 一种高效节能环保的石英环制备工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5659718A (en) * | 1979-10-19 | 1981-05-23 | Ihara Chem Ind Co Ltd | Preparation of substituted phenoxycarboxylic acid derivative |
| DE3031738A1 (de) * | 1980-08-22 | 1982-04-01 | Troponwerke GmbH & Co KG, 5000 Köln | Verfahren zur herstellung von benzo (b) thiophen-derivaten und ihre verwendung als zwischenprodukte |
| US4537984A (en) * | 1983-05-19 | 1985-08-27 | Nissan Chemical Industries Ltd. | Process for producing 2-(4-hydroxyphenoxy) propionate derivatives |
| PL152990B1 (pl) * | 1987-06-20 | 1991-02-28 | Sposób wytwarzania kwasu 2-(o-formylofenoksy) heksanowego | |
| FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| WO1997024122A1 (en) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
-
1999
- 1999-10-21 FR FR9913250A patent/FR2800067B1/fr not_active Expired - Fee Related
-
2000
- 2000-10-23 WO PCT/FR2000/002937 patent/WO2001028974A2/fr active IP Right Grant
- 2000-10-23 DK DK00971474T patent/DK1222159T3/da active
- 2000-10-23 CN CNB008144761A patent/CN1268601C/zh not_active Expired - Fee Related
- 2000-10-23 EP EP00971474A patent/EP1222159B1/fr not_active Expired - Lifetime
- 2000-10-23 JP JP2001531779A patent/JP2003512347A/ja active Pending
- 2000-10-23 DE DE60020587T patent/DE60020587T2/de not_active Expired - Lifetime
- 2000-10-23 CA CA002387713A patent/CA2387713A1/fr not_active Abandoned
- 2000-10-23 PT PT00971474T patent/PT1222159E/pt unknown
- 2000-10-23 AT AT00971474T patent/ATE296795T1/de not_active IP Right Cessation
- 2000-10-23 US US10/110,441 patent/US6855842B1/en not_active Expired - Fee Related
- 2000-10-23 AU AU10324/01A patent/AU1032401A/en not_active Abandoned
- 2000-10-23 ES ES00971474T patent/ES2239623T3/es not_active Expired - Lifetime
- 2000-10-23 HU HU0203188A patent/HUP0203188A3/hu unknown
- 2000-10-23 BR BR0014808-3A patent/BR0014808A/pt not_active Application Discontinuation
-
2004
- 2004-10-25 US US10/972,575 patent/US20050113596A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0014808A (pt) | 2002-06-11 |
| CN1268601C (zh) | 2006-08-09 |
| PT1222159E (pt) | 2005-08-31 |
| ATE296795T1 (de) | 2005-06-15 |
| WO2001028974A2 (fr) | 2001-04-26 |
| US6855842B1 (en) | 2005-02-15 |
| US20050113596A1 (en) | 2005-05-26 |
| JP2003512347A (ja) | 2003-04-02 |
| CN1379754A (zh) | 2002-11-13 |
| DK1222159T3 (da) | 2005-08-08 |
| WO2001028974A3 (fr) | 2001-12-06 |
| EP1222159B1 (fr) | 2005-06-01 |
| AU1032401A (en) | 2001-04-30 |
| FR2800067A1 (fr) | 2001-04-27 |
| DE60020587T2 (de) | 2005-11-10 |
| ES2239623T3 (es) | 2005-10-01 |
| HUP0203188A2 (hu) | 2003-03-28 |
| CA2387713A1 (fr) | 2001-04-26 |
| DE60020587D1 (de) | 2005-07-07 |
| FR2800067B1 (fr) | 2004-12-17 |
| EP1222159A2 (fr) | 2002-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0203188A3 (en) | Intermediates for making a benzofuran or benzothiophene derivative nitrated in position 5 and uses thereof | |
| AP9801255A0 (en) | 4"-substituted-9-deoxo-9a-aza-9a-homoerythromyci N a derivatives | |
| HK1029300A1 (en) | Movable frog toy | |
| IL149775A0 (en) | Protective material | |
| PL328610A1 (en) | Latch-type locating mechanism | |
| IL121200A (en) | Marker | |
| IL152894A0 (en) | Novel benzothiophene derivatives | |
| EP0979076A4 (en) | INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF BENZO b] THIOPHENES | |
| GB9924893D0 (en) | Impact resistant material | |
| GB9716724D0 (en) | A casting roll | |
| GB9901323D0 (en) | Freeface 1 | |
| GB9816620D0 (en) | Casting rolls | |
| GB9916299D0 (en) | Dogex 1 | |
| GB9809109D0 (en) | Lactone | |
| GB9620419D0 (en) | A game | |
| GB9705712D0 (en) | A game | |
| GB2328171B (en) | Casting rolls | |
| IL145865A (en) | Benzothiophene derivatives | |
| ZA959752B (en) | Thiophene derivatives | |
| GB0004338D0 (en) | J-prop 5 | |
| GB9904188D0 (en) | J-prop 3 | |
| GB9929169D0 (en) | 7430556002 | |
| GB9923703D0 (en) | Sealguard 1 | |
| GB9919752D0 (en) | Auto-mat 2000 | |
| GB9917686D0 (en) | Pedulator 2 |