HUP0200013A2 - 3,6-disubstituted penam sulfone derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
3,6-disubstituted penam sulfone derivatives, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- HUP0200013A2 HUP0200013A2 HU0200013A HUP0200013A HUP0200013A2 HU P0200013 A2 HUP0200013 A2 HU P0200013A2 HU 0200013 A HU0200013 A HU 0200013A HU P0200013 A HUP0200013 A HU P0200013A HU P0200013 A2 HUP0200013 A2 HU P0200013A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- disubstituted
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- -1 3,6-disubstituted penam sulfone Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 1
- 125000005205 alkoxycarbonyloxyalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány (I) és (II) általános képletű vegyületekre ésgyógyászatilag elfogadható sóira vonatkozik. Az (I) és (II) általánosképletben n értéke 0 vagy 1 és amikor n értéke 1, R jelentése 5- vagy 6-tagúheterociklusos gyűrű, hidroxilcsoport, halogénatom, oxo-, karbamoil-,alkoxi- vagy diszubsztituált aminocsoport; amikor n értéke 0,Rjelentése észter-, ciano- vagy amidcsoport; X jelentése =CH- vagy -NH- képletű csoport; R3 jelentése ciano-, metoxi- vagyacetamidocsoport; R1 jelentése hidrogénatom, alkilcsoport, negatívtöltés, egy kation, mégpedig nátrium-, kálium-, vagytetralkilammóniumion, aciloxialkil- vagy alkoxikarboniloxialkil-csoport és R2 jelentése hidrogénatom, acil-, triszubsztituált szilil-,karbamoil-, dialkil-aminokarbonil-csoport vagy egy aminosavmaradék. Atalálmány kiterjed, a fenti vegyületek előállítására, továbbá azezeket tartalmazó antibakteriális hatású gyógyszerkészítményekre is. ÓThe invention relates to compounds of formulas (I) and (II) and their pharmaceutically acceptable salts. In formulas (I) and (II), n is 0 or 1 and when n is 1, R is a 5- or 6-membered heterocyclic ring, hydroxyl group, halogen atom, oxo-, carbamoyl-, alkoxy- or disubstituted amino group; when n is 0, R is an ester, cyano or amide group; X is a group of formula =CH- or -NH-; R 3 is cyano, methoxy or acetamido; R1 is a hydrogen atom, an alkyl group, a negative charge, a cation, namely a sodium, potassium or tetraalkylammonium ion, an acyloxyalkyl or alkoxycarbonyloxyalkyl group and R2 is a hydrogen atom, an acyl, trisubstituted silyl, carbamoyl, dialkylaminocarbonyl group or an amino acid residue. The invention covers the production of the above compounds, as well as pharmaceutical preparations containing them with an antibacterial effect. HE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23772699A | 1999-01-26 | 1999-01-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0200013A2 true HUP0200013A2 (en) | 2002-05-29 |
| HUP0200013A3 HUP0200013A3 (en) | 2002-10-28 |
Family
ID=22894903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0200013A HUP0200013A3 (en) | 1999-01-26 | 2000-01-26 | 3,6-disubstituted penam sulfone derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1144418A1 (en) |
| JP (1) | JP2002535335A (en) |
| KR (1) | KR20010101649A (en) |
| CN (1) | CN1188417C (en) |
| AU (1) | AU2624600A (en) |
| BG (1) | BG105737A (en) |
| BR (1) | BR0007729A (en) |
| CA (1) | CA2355738A1 (en) |
| CZ (1) | CZ20012691A3 (en) |
| EA (1) | EA200100813A1 (en) |
| HK (1) | HK1038747A1 (en) |
| HU (1) | HUP0200013A3 (en) |
| ID (1) | ID29400A (en) |
| IL (1) | IL144116A0 (en) |
| NO (1) | NO20013640D0 (en) |
| PL (1) | PL349874A1 (en) |
| SK (1) | SK10142001A3 (en) |
| TR (1) | TR200102133T2 (en) |
| WO (1) | WO2000043399A1 (en) |
| ZA (1) | ZA200104323B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5705751B2 (en) * | 2009-03-10 | 2015-04-22 | レール・リキード−ソシエテ・アノニム・プール・レテュード・エ・レクスプロワタシオン・デ・プロセデ・ジョルジュ・クロード | Cyclic amino compounds for low-k silylation |
| CN109422765B (en) * | 2017-09-05 | 2020-08-28 | 香港理工大学深圳研究院 | C-class beta-lactamase inhibitor and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2076812A (en) * | 1980-05-22 | 1981-12-09 | Ciba Geigy Ag | Penam-dioxide compounds, processes for their manufacture, and their use |
| GR77151B (en) * | 1982-01-11 | 1984-09-07 | Prizer | |
| US4562073A (en) * | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| US4503040A (en) * | 1984-02-27 | 1985-03-05 | Pfizer Inc. | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
| US4591459A (en) * | 1984-12-03 | 1986-05-27 | Pfizer Inc. | Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides |
| TW383308B (en) * | 1993-08-24 | 2000-03-01 | Hoffmann La Roche | 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors |
-
2000
- 2000-01-26 JP JP2000594815A patent/JP2002535335A/en active Pending
- 2000-01-26 WO PCT/US2000/001630 patent/WO2000043399A1/en not_active Application Discontinuation
- 2000-01-26 EA EA200100813A patent/EA200100813A1/en unknown
- 2000-01-26 CN CNB008030766A patent/CN1188417C/en not_active Expired - Fee Related
- 2000-01-26 SK SK1014-2001A patent/SK10142001A3/en unknown
- 2000-01-26 CZ CZ20012691A patent/CZ20012691A3/en unknown
- 2000-01-26 CA CA002355738A patent/CA2355738A1/en not_active Abandoned
- 2000-01-26 ID IDW00200101522A patent/ID29400A/en unknown
- 2000-01-26 KR KR1020017009276A patent/KR20010101649A/en not_active Application Discontinuation
- 2000-01-26 BR BR0007729-1A patent/BR0007729A/en not_active IP Right Cessation
- 2000-01-26 EP EP00904498A patent/EP1144418A1/en not_active Withdrawn
- 2000-01-26 HU HU0200013A patent/HUP0200013A3/en unknown
- 2000-01-26 PL PL00349874A patent/PL349874A1/en not_active Application Discontinuation
- 2000-01-26 IL IL14411600A patent/IL144116A0/en unknown
- 2000-01-26 AU AU26246/00A patent/AU2624600A/en not_active Abandoned
- 2000-01-26 TR TR2001/02133T patent/TR200102133T2/en unknown
-
2001
- 2001-05-25 ZA ZA200104323A patent/ZA200104323B/en unknown
- 2001-07-24 NO NO20013640A patent/NO20013640D0/en not_active Application Discontinuation
- 2001-07-26 BG BG105737A patent/BG105737A/en unknown
-
2002
- 2002-01-10 HK HK02100179.1A patent/HK1038747A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2355738A1 (en) | 2000-07-27 |
| SK10142001A3 (en) | 2002-07-02 |
| JP2002535335A (en) | 2002-10-22 |
| TR200102133T2 (en) | 2001-12-21 |
| CZ20012691A3 (en) | 2002-06-12 |
| BR0007729A (en) | 2001-10-30 |
| CN1337965A (en) | 2002-02-27 |
| HUP0200013A3 (en) | 2002-10-28 |
| BG105737A (en) | 2002-05-31 |
| WO2000043399A1 (en) | 2000-07-27 |
| HK1038747A1 (en) | 2002-03-28 |
| CN1188417C (en) | 2005-02-09 |
| ZA200104323B (en) | 2002-08-26 |
| NO20013640L (en) | 2001-07-24 |
| EA200100813A1 (en) | 2003-02-27 |
| KR20010101649A (en) | 2001-11-14 |
| IL144116A0 (en) | 2002-05-23 |
| PL349874A1 (en) | 2002-09-23 |
| ID29400A (en) | 2001-08-30 |
| EP1144418A1 (en) | 2001-10-17 |
| NO20013640D0 (en) | 2001-07-24 |
| AU2624600A (en) | 2000-08-07 |
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