EA200100813A1 - 3,6-DESIGNED DERIVATIVES OF PENAMUSPHONE AS BACTERICIDAL SUBSTANCES - Google Patents
3,6-DESIGNED DERIVATIVES OF PENAMUSPHONE AS BACTERICIDAL SUBSTANCESInfo
- Publication number
- EA200100813A1 EA200100813A1 EA200100813A EA200100813A EA200100813A1 EA 200100813 A1 EA200100813 A1 EA 200100813A1 EA 200100813 A EA200100813 A EA 200100813A EA 200100813 A EA200100813 A EA 200100813A EA 200100813 A1 EA200100813 A1 EA 200100813A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- penamusphone
- cyano
- hydrogen
- bactericidal substances
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Предоставляются соединения, имеющие формулы (I) и (II), в которых n равно 0 или 1, и когда n=1, R представляет 5- или 6-членное гетероциклическое кольцо, гидрокси, галоген, оксо, карбамоил, алкокси или дизамещенный амино, когда n=0, R представляет сложный эфир, циано или амидную группу; Х представляет СН или NH; Rпредставляет циано, метокси или ацетамидо; Rпредставляет водород, алкил, отрицательный заряд, катион, выбранный из группы, состоящей из натрия, калия и тетраалкиламмония, и ацилоксиалкил или алкоксикарбонилоксиалкил; и Rпредставляет водород, ацил, тризамещенный силилкарбамоил или аминокислотный остаток; или их фармацевтически приемлемые соли.Международная заявка была опубликована вместе с отчетом о международном поиске.Compounds of formulas (I) and (II) are provided in which n is 0 or 1, and when n = 1, R represents a 5- or 6-membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino when n = 0, R is an ester, cyano or amide group; X is CH or NH; R 1 is cyano, methoxy, or acetamido; R 1 is hydrogen, alkyl, negative charge, a cation selected from the group consisting of sodium, potassium and tetraalkylammonium, and acyloxyalkyl or alkoxycarbonyloxyalkyl; and R 5 is hydrogen, acyl, trisubstituted silylcarbamoyl, or amino acid residue; or their pharmaceutically acceptable salts. The international application was published along with an international search report.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23772699A | 1999-01-26 | 1999-01-26 | |
| PCT/US2000/001630 WO2000043399A1 (en) | 1999-01-26 | 2000-01-26 | 3,6-disubstituted penam sulfone derivatives as antibacterials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200100813A1 true EA200100813A1 (en) | 2003-02-27 |
Family
ID=22894903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100813A EA200100813A1 (en) | 1999-01-26 | 2000-01-26 | 3,6-DESIGNED DERIVATIVES OF PENAMUSPHONE AS BACTERICIDAL SUBSTANCES |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1144418A1 (en) |
| JP (1) | JP2002535335A (en) |
| KR (1) | KR20010101649A (en) |
| CN (1) | CN1188417C (en) |
| AU (1) | AU2624600A (en) |
| BG (1) | BG105737A (en) |
| BR (1) | BR0007729A (en) |
| CA (1) | CA2355738A1 (en) |
| CZ (1) | CZ20012691A3 (en) |
| EA (1) | EA200100813A1 (en) |
| HK (1) | HK1038747A1 (en) |
| HU (1) | HUP0200013A3 (en) |
| ID (1) | ID29400A (en) |
| IL (1) | IL144116A0 (en) |
| NO (1) | NO20013640D0 (en) |
| PL (1) | PL349874A1 (en) |
| SK (1) | SK10142001A3 (en) |
| TR (1) | TR200102133T2 (en) |
| WO (1) | WO2000043399A1 (en) |
| ZA (1) | ZA200104323B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2406267B1 (en) * | 2009-03-10 | 2019-02-20 | L'Air Liquide Société Anonyme pour l'Etude et l'Exploitation des Procédés Georges Claude | Cyclic amino compounds for low-k silylation |
| CN109422765B (en) * | 2017-09-05 | 2020-08-28 | 香港理工大学深圳研究院 | C-class beta-lactamase inhibitor and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2076812A (en) * | 1980-05-22 | 1981-12-09 | Ciba Geigy Ag | Penam-dioxide compounds, processes for their manufacture, and their use |
| EP0083977A1 (en) * | 1982-01-11 | 1983-07-20 | Pfizer Inc. | 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor |
| US4562073A (en) * | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| US4503040A (en) * | 1984-02-27 | 1985-03-05 | Pfizer Inc. | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
| US4591459A (en) * | 1984-12-03 | 1986-05-27 | Pfizer Inc. | Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides |
| TW383308B (en) * | 1993-08-24 | 2000-03-01 | Hoffmann La Roche | 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors |
-
2000
- 2000-01-26 IL IL14411600A patent/IL144116A0/en unknown
- 2000-01-26 AU AU26246/00A patent/AU2624600A/en not_active Abandoned
- 2000-01-26 HU HU0200013A patent/HUP0200013A3/en unknown
- 2000-01-26 PL PL00349874A patent/PL349874A1/en not_active Application Discontinuation
- 2000-01-26 CN CNB008030766A patent/CN1188417C/en not_active Expired - Fee Related
- 2000-01-26 JP JP2000594815A patent/JP2002535335A/en active Pending
- 2000-01-26 EP EP00904498A patent/EP1144418A1/en not_active Withdrawn
- 2000-01-26 CZ CZ20012691A patent/CZ20012691A3/en unknown
- 2000-01-26 ID IDW00200101522A patent/ID29400A/en unknown
- 2000-01-26 BR BR0007729-1A patent/BR0007729A/en not_active IP Right Cessation
- 2000-01-26 TR TR2001/02133T patent/TR200102133T2/en unknown
- 2000-01-26 SK SK1014-2001A patent/SK10142001A3/en unknown
- 2000-01-26 KR KR1020017009276A patent/KR20010101649A/en not_active Application Discontinuation
- 2000-01-26 EA EA200100813A patent/EA200100813A1/en unknown
- 2000-01-26 CA CA002355738A patent/CA2355738A1/en not_active Abandoned
- 2000-01-26 WO PCT/US2000/001630 patent/WO2000043399A1/en not_active Application Discontinuation
-
2001
- 2001-05-25 ZA ZA200104323A patent/ZA200104323B/en unknown
- 2001-07-24 NO NO20013640A patent/NO20013640D0/en not_active Application Discontinuation
- 2001-07-26 BG BG105737A patent/BG105737A/en unknown
-
2002
- 2002-01-10 HK HK02100179.1A patent/HK1038747A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1038747A1 (en) | 2002-03-28 |
| BG105737A (en) | 2002-05-31 |
| CZ20012691A3 (en) | 2002-06-12 |
| TR200102133T2 (en) | 2001-12-21 |
| IL144116A0 (en) | 2002-05-23 |
| EP1144418A1 (en) | 2001-10-17 |
| AU2624600A (en) | 2000-08-07 |
| HUP0200013A2 (en) | 2002-05-29 |
| BR0007729A (en) | 2001-10-30 |
| NO20013640L (en) | 2001-07-24 |
| HUP0200013A3 (en) | 2002-10-28 |
| PL349874A1 (en) | 2002-09-23 |
| KR20010101649A (en) | 2001-11-14 |
| WO2000043399A1 (en) | 2000-07-27 |
| ID29400A (en) | 2001-08-30 |
| ZA200104323B (en) | 2002-08-26 |
| SK10142001A3 (en) | 2002-07-02 |
| JP2002535335A (en) | 2002-10-22 |
| CN1337965A (en) | 2002-02-27 |
| NO20013640D0 (en) | 2001-07-24 |
| CN1188417C (en) | 2005-02-09 |
| CA2355738A1 (en) | 2000-07-27 |
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