HUP0105327A2 - Eljárás 3-[2-(3,4-dimetoxi-benzoil)-4,5-dimetoxi-fenil]-pentán-2-on elżállítására - Google Patents

Eljárás 3-[2-(3,4-dimetoxi-benzoil)-4,5-dimetoxi-fenil]-pentán-2-on elżállítására

Info

Publication number
HUP0105327A2
HUP0105327A2 HU0105327A HUP0105327A HUP0105327A2 HU P0105327 A2 HUP0105327 A2 HU P0105327A2 HU 0105327 A HU0105327 A HU 0105327A HU P0105327 A HUP0105327 A HU P0105327A HU P0105327 A2 HUP0105327 A2 HU P0105327A2
Authority
HU
Hungary
Prior art keywords
dimethoxy
benzoyl
phenyl
dimethoxyphenyl
pentane
Prior art date
Application number
HU0105327A
Other languages
English (en)
Inventor
dr. Samu Erika Molnárné
Gyula Simig
Pál Vágó
Zoltán Greff
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU0105327A priority Critical patent/HUP0105327A3/hu
Publication of HU0105327D0 publication Critical patent/HU0105327D0/hu
Priority to CZ2004792A priority patent/CZ2004792A3/cs
Priority to PCT/HU2002/000141 priority patent/WO2003050092A2/en
Priority to PL02370036A priority patent/PL370036A1/xx
Priority to SK279-2004A priority patent/SK2792004A3/sk
Priority to AU2002348942A priority patent/AU2002348942A1/en
Priority to EP02781451A priority patent/EP1465879A2/en
Publication of HUP0105327A2 publication Critical patent/HUP0105327A2/hu
Priority to BG108801A priority patent/BG108801A/xx
Publication of HUP0105327A3 publication Critical patent/HUP0105327A3/hu

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány a (I) képletű 3-[2-(3,4-dimetoxi-benzoil)-4,5-dimetoxi-fenil]-pentán-2-on előállítására vonatkozik, oly módon, hogy a (II)képletű vegyületet brómozzák; a kapott (III) képletű vegyületet 1-4szénatomos alifás alkohollal vagy 2-6 szénatomos alifás diollalreagáltatják; a kapott (IV) általános képletű vegyületet (ahol R1 ésR2 jelentése 1-4 szénatomos alkilcsoport vagy R1 és R2 együtt 2-6szénatomos alkiléncsoportot képez) közvetlenül vagy az (V) általánosképletű vegyületen keresztül (VI) általános képletű vegyülettéalakítják; majd a kapott (VI) általános képletű vegyületethidrolizálják. Az (I) képletű vegyület ismert gyógyászati közbensőtermék, amely a tofisopam nemzetközi szabadnevű anxiolitikumelőállításánál alkalmazható. Ó
HU0105327A 2001-12-13 2001-12-13 Process for the production of 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentane-2-one HUP0105327A3 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
HU0105327A HUP0105327A3 (en) 2001-12-13 2001-12-13 Process for the production of 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentane-2-one
CZ2004792A CZ2004792A3 (cs) 2001-12-13 2002-12-12 Způsob přípravy farmaceutických meziproduktů
PCT/HU2002/000141 WO2003050092A2 (en) 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates
PL02370036A PL370036A1 (en) 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates
SK279-2004A SK2792004A3 (en) 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates
AU2002348942A AU2002348942A1 (en) 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates
EP02781451A EP1465879A2 (en) 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates
BG108801A BG108801A (en) 2001-12-13 2004-07-13 Process for the preparation of pharmaceutical intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0105327A HUP0105327A3 (en) 2001-12-13 2001-12-13 Process for the production of 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentane-2-one

Publications (3)

Publication Number Publication Date
HU0105327D0 HU0105327D0 (en) 2002-02-28
HUP0105327A2 true HUP0105327A2 (hu) 2003-09-29
HUP0105327A3 HUP0105327A3 (en) 2005-11-28

Family

ID=89979995

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105327A HUP0105327A3 (en) 2001-12-13 2001-12-13 Process for the production of 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentane-2-one

Country Status (1)

Country Link
HU (1) HUP0105327A3 (hu)

Also Published As

Publication number Publication date
HUP0105327A3 (en) 2005-11-28
HU0105327D0 (en) 2002-02-28

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Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU