BG108801A - Process for the preparation of pharmaceutical intermediates - Google Patents

Process for the preparation of pharmaceutical intermediates

Info

Publication number
BG108801A
BG108801A BG108801A BG10880104A BG108801A BG 108801 A BG108801 A BG 108801A BG 108801 A BG108801 A BG 108801A BG 10880104 A BG10880104 A BG 10880104A BG 108801 A BG108801 A BG 108801A
Authority
BG
Bulgaria
Prior art keywords
preparation
general formula
pharmaceutical intermediates
dimethoxy
tofisopam
Prior art date
Application number
BG108801A
Other languages
Bulgarian (bg)
Inventor
Samu Erika Molnarne
Gyula Simig
Pal Vago
Zoltan Greff
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0105326A external-priority patent/HU225411B1/en
Priority claimed from HU0105327A external-priority patent/HUP0105327A3/en
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of BG108801A publication Critical patent/BG108801A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a new process for the preparation of 3-[2-(3,4-dimethoxy-benzoyl)-4,5-dimethoxy-phenyl]-pentane-2-on-ketals with general formula which comprises reacting a compound of general formula wherein every R1 and R2 independently each stands for C1-4 alkyl or together form C2-C6-alkylene group, with 3-4-dimethoxybenzaldehyde. The compounds with general formula II are pharmaceutical intermediates useful for the synthesis of the anxiolytic agent tofisopam.
BG108801A 2001-12-13 2004-07-13 Process for the preparation of pharmaceutical intermediates BG108801A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0105326A HU225411B1 (en) 2001-12-13 2001-12-13 Process for producing tofisopam
HU0105327A HUP0105327A3 (en) 2001-12-13 2001-12-13 Process for the production of 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentane-2-one

Publications (1)

Publication Number Publication Date
BG108801A true BG108801A (en) 2005-04-30

Family

ID=89979996

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108801A BG108801A (en) 2001-12-13 2004-07-13 Process for the preparation of pharmaceutical intermediates

Country Status (7)

Country Link
EP (1) EP1465879A2 (en)
AU (1) AU2002348942A1 (en)
BG (1) BG108801A (en)
CZ (1) CZ2004792A3 (en)
PL (1) PL370036A1 (en)
SK (1) SK2792004A3 (en)
WO (1) WO2003050092A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227044B1 (en) * 2002-12-16 2010-05-28 Egis Gyogyszergyar Nyilvanosan Process for producing 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentan-2-one
FR2996845A1 (en) * 2012-10-12 2014-04-18 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF 3- (2-BROMO-4,5-DIMETHOXYPHENYL) PROPANENITRILE, AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA712798B (en) * 1970-11-06 1972-02-23 Egyt Gyogyszervegyeszeti Gyar New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same

Also Published As

Publication number Publication date
SK2792004A3 (en) 2004-11-03
CZ2004792A3 (en) 2004-12-15
EP1465879A2 (en) 2004-10-13
AU2002348942A1 (en) 2003-06-23
WO2003050092A2 (en) 2003-06-19
PL370036A1 (en) 2005-05-16
WO2003050092A3 (en) 2003-11-06
AU2002348942A8 (en) 2003-06-23

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