HUP0104719A2 - Biológiai vizsgálati eljárás béta/alfa-ösztrogénreceptorra szelektív modulátorok azonosítására - Google Patents

Biológiai vizsgálati eljárás béta/alfa-ösztrogénreceptorra szelektív modulátorok azonosítására

Info

Publication number
HUP0104719A2
HUP0104719A2 HU0104719A HUP0104719A HUP0104719A2 HU P0104719 A2 HUP0104719 A2 HU P0104719A2 HU 0104719 A HU0104719 A HU 0104719A HU P0104719 A HUP0104719 A HU P0104719A HU P0104719 A2 HUP0104719 A2 HU P0104719A2
Authority
HU
Hungary
Prior art keywords
betha
bioassay
alfa
estrogen receptor
selective modulators
Prior art date
Application number
HU0104719A
Other languages
English (en)
Inventor
Ramesh A. Bhat
Heather Harris
Original Assignee
American Home Products Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp. filed Critical American Home Products Corp.
Publication of HUP0104719A2 publication Critical patent/HUP0104719A2/hu
Publication of HUP0104719A3 publication Critical patent/HUP0104719A3/hu

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A tal lm ny t rgya hormonreceptorokkal kapcsolatos. A tal lm ny t rgyt elj r sok képezik olyan vegyületek azonosít s ra, amelyekszelektíven képesek alfa és béta altípusú "sztrogénreceptorokat (ER)aktiv lni. A tal lm ny t rgy t képezik tov bb a tal lm ny szerinti eljr sok végrehajt s ra alkalmas teszt-reagenskészletek. A tal lm nyszerinti megold s alkalmas "sztrogénreceptorokkal k"lcs"nhat sba lépőgyógy szati hatóanyagok kutat s ra, tesztelésére. Ó
HU0104719A 1998-12-18 1999-12-17 Bioassay for identifying estrogen receptor-betha/alfa selective modulators HUP0104719A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11279098P 1998-12-18 1998-12-18
PCT/US1999/029856 WO2000037681A1 (en) 1998-12-18 1999-12-17 BIOASSAY FOR IDENTIFYING ESTROGEN RECEPTOR-β/α SELECTIVE MODULATORS

Publications (2)

Publication Number Publication Date
HUP0104719A2 true HUP0104719A2 (hu) 2002-04-29
HUP0104719A3 HUP0104719A3 (en) 2004-03-01

Family

ID=22345864

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104719A HUP0104719A3 (en) 1998-12-18 1999-12-17 Bioassay for identifying estrogen receptor-betha/alfa selective modulators

Country Status (9)

Country Link
EP (1) EP1141405A1 (hu)
JP (1) JP2002533098A (hu)
CN (1) CN1352699A (hu)
AU (1) AU760784B2 (hu)
CA (1) CA2352203A1 (hu)
HU (1) HUP0104719A3 (hu)
NO (1) NO20012999L (hu)
NZ (1) NZ512347A (hu)
WO (1) WO2000037681A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660468B1 (en) 1998-10-27 2003-12-09 Board Of Trustees Of The University Of Arkansas Vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
EP1400810A3 (en) * 1999-04-09 2005-03-02 Karo Bio Ab Estrogen receptors and bone disease
CA2418952A1 (en) 2000-08-08 2002-02-14 Wyeth A novel member of the lysyl oxidase gene family
DE10046647A1 (de) * 2000-09-20 2002-03-28 Ludwig Wildt Verfahren zur Bestimmung der Peptidhormon-Aktivitäten oder der Steroidhormon-Aktivitäten eines Materials oder Stoffgemisches
EP1310799B1 (en) 2001-11-07 2005-12-21 Schering AG In vitro screening for ligands of the estrogen receptor
CN1314966C (zh) * 2004-12-03 2007-05-09 湖南农业大学 一种猪金属硫蛋白的检测方法
WO2010040446A1 (en) * 2008-10-09 2010-04-15 Merck Patent Gmbh Estrogen and anti-estrogen marker genes
CN109295214A (zh) * 2018-11-02 2019-02-01 张磊 雌激素受体α基因与女性眼病发生时间相关

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
JP2001514843A (ja) * 1997-09-04 2001-09-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＡＰ１部位でのエストロゲンレセプターＥＲαおよびＥＲβの弁別的なリガンド活性化

Also Published As

Publication number Publication date
EP1141405A1 (en) 2001-10-10
NO20012999D0 (no) 2001-06-15
CN1352699A (zh) 2002-06-05
NO20012999L (no) 2001-08-15
AU2187900A (en) 2000-07-12
HUP0104719A3 (en) 2004-03-01
WO2000037681A1 (en) 2000-06-29
JP2002533098A (ja) 2002-10-08
AU760784B2 (en) 2003-05-22
CA2352203A1 (en) 2000-06-29
NZ512347A (en) 2003-12-19

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