AU760784B2 - Bioassay for identifying estrogen receptor-beta/alpha selective modulators - Google Patents

Bioassay for identifying estrogen receptor-beta/alpha selective modulators Download PDF

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Publication number
AU760784B2
AU760784B2 AU21879/00A AU2187900A AU760784B2 AU 760784 B2 AU760784 B2 AU 760784B2 AU 21879/00 A AU21879/00 A AU 21879/00A AU 2187900 A AU2187900 A AU 2187900A AU 760784 B2 AU760784 B2 AU 760784B2
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AU
Australia
Prior art keywords
cells
expression
polypeptide
estrogen
transformed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU21879/00A
Other languages
English (en)
Other versions
AU2187900A (en
Inventor
Ramesh A. Bhat
Heather Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of AU2187900A publication Critical patent/AU2187900A/en
Assigned to WYETH reassignment WYETH Amend patent request/document other than specification (104) Assignors: AMERICAN HOME PRODUCTS CORPORATION
Application granted granted Critical
Publication of AU760784B2 publication Critical patent/AU760784B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743Steroid hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU21879/00A 1998-12-18 1999-12-17 Bioassay for identifying estrogen receptor-beta/alpha selective modulators Ceased AU760784B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11279098P 1998-12-18 1998-12-18
US60/112790 1998-12-18
PCT/US1999/029856 WO2000037681A1 (en) 1998-12-18 1999-12-17 BIOASSAY FOR IDENTIFYING ESTROGEN RECEPTOR-β/α SELECTIVE MODULATORS

Publications (2)

Publication Number Publication Date
AU2187900A AU2187900A (en) 2000-07-12
AU760784B2 true AU760784B2 (en) 2003-05-22

Family

ID=22345864

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21879/00A Ceased AU760784B2 (en) 1998-12-18 1999-12-17 Bioassay for identifying estrogen receptor-beta/alpha selective modulators

Country Status (9)

Country Link
EP (1) EP1141405A1 (hu)
JP (1) JP2002533098A (hu)
CN (1) CN1352699A (hu)
AU (1) AU760784B2 (hu)
CA (1) CA2352203A1 (hu)
HU (1) HUP0104719A3 (hu)
NO (1) NO20012999L (hu)
NZ (1) NZ512347A (hu)
WO (1) WO2000037681A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660468B1 (en) 1998-10-27 2003-12-09 Board Of Trustees Of The University Of Arkansas Vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
EP1400810A3 (en) * 1999-04-09 2005-03-02 Karo Bio Ab Estrogen receptors and bone disease
CA2418952A1 (en) 2000-08-08 2002-02-14 Wyeth A novel member of the lysyl oxidase gene family
DE10046647A1 (de) * 2000-09-20 2002-03-28 Ludwig Wildt Verfahren zur Bestimmung der Peptidhormon-Aktivitäten oder der Steroidhormon-Aktivitäten eines Materials oder Stoffgemisches
EP1310799B1 (en) 2001-11-07 2005-12-21 Schering AG In vitro screening for ligands of the estrogen receptor
CN1314966C (zh) * 2004-12-03 2007-05-09 湖南农业大学 一种猪金属硫蛋白的检测方法
WO2010040446A1 (en) * 2008-10-09 2010-04-15 Merck Patent Gmbh Estrogen and anti-estrogen marker genes
CN109295214A (zh) * 2018-11-02 2019-02-01 张磊 雌激素受体α基因与女性眼病发生时间相关

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
JP2001514843A (ja) * 1997-09-04 2001-09-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア AP1部位でのエストロゲンレセプターERαおよびERβの弁別的なリガンド活性化

Also Published As

Publication number Publication date
HUP0104719A2 (hu) 2002-04-29
EP1141405A1 (en) 2001-10-10
NO20012999D0 (no) 2001-06-15
CN1352699A (zh) 2002-06-05
NO20012999L (no) 2001-08-15
AU2187900A (en) 2000-07-12
HUP0104719A3 (en) 2004-03-01
WO2000037681A1 (en) 2000-06-29
JP2002533098A (ja) 2002-10-08
CA2352203A1 (en) 2000-06-29
NZ512347A (en) 2003-12-19

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Owner name: WYETH

Free format text: FORMER NAME: AMERICAN HOME PRODUCTS CORPORATION

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