HUP0103452A2 - MMP inhibitor hidroxi-pipekolát-hidroxámsav származékok és a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

MMP inhibitor hidroxi-pipekolát-hidroxámsav származékok és a vegyületeket tartalmazó gyógyászati készítmények

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Publication number
HUP0103452A2
HUP0103452A2 HU0103452A HUP0103452A HUP0103452A2 HU P0103452 A2 HUP0103452 A2 HU P0103452A2 HU 0103452 A HU0103452 A HU 0103452A HU P0103452 A HUP0103452 A HU P0103452A HU P0103452 A2 HUP0103452 A2 HU P0103452A2
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Hungary
Prior art keywords
alkyl
heteroaryl
aryl
carbon
atom
Prior art date
Application number
HU0103452A
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English (en)
Inventor
Louis Stanley Chupak
Michael Anthony Letavic
Kim Francis Mcclure
Mark Carl Noe
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Pfizer Products Inc.
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Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0103452A2 publication Critical patent/HUP0103452A2/hu
Publication of HUP0103452A3 publication Critical patent/HUP0103452A3/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
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    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

A jelen tal lm ny t rgy t azok az (I) ltal nos képletű vegyületekképezik, ahol a képletben szereplő R1, R2, R3, R4, R5, R6, R7, R8, R9,valamint Ar jelentése az al bbiakban kerül ismertetésre, amelyek azarthritis, a rosszindulatú daganatos betegségek vagy egyéb m trixmetalloprotein z vagy emberi reprolizin aktivit ssal jellemzett egyébbetegség kezelésére alkalmasak. Emellett a jelen tal lm ny szerintivegyületek felhaszn lhatók standard nem szteroid gyullad sellenesgyógyszerekkel (NAID's), COX-2 inhibitorokkal és analgetikumokkalkombin lt ter pi kban és olyan citotoxikus gyógyszerekkel kombin lva,mint az adriamycin, daunomycin, cisz-platinum, etoposid, taxol,taxoter és egyéb olyan alkaloidok, mint a vincristin, a rosszindulatúdaganatos betegségek kezelésében. R1-R8 jelentése a hidroxicsoport,hidrogénatom, halogénatom (előny"sen klór- vagy fluoratom), -CN, 1-6szénatomos alkil, 2-6 szénatomos alkenil, (6-10 szénatomos aril)-(2-6szénatomos alkenil), (2-9 szénatomos heteroaril)-(2-6 szénatomosalkenil), 2-6 szénatomos alkinil, (6-10 szénatomos aril)-(2-6szénatomos alkinil), (2-9 szénatomos heteroaril)-(2-6 szénatomosalkinil), 1-6 szénatomos alkil-amino, 1-6 szénatomos alkiltio, 1-6szénatomos alkoxi, perfluor-(1-6 szénatomos alkil), 6-10 szénatomosaril, 2-9 szénatomos heteroaril, 6-10 szénatomos aril-amino, 6-10szénatomos aril-tio, 6-10 szénatomos ariloxi, 2-9 szénatomosheteroaril-amino, 2-9 szénatomos heteroaril-tio, 2-9 szénatomosheteroaril-oxi, 3-6 szénatomos cikloalkil, (1-6 szénatomos alkil)-(hidroxi-metilén), piperidil, (1-6 szénatomos alkil)-piperidil, 1-6szénatomos acilamino, 1-6 szénatomos acil-tio, 1-6 szénatomos aciloxi,(1-6 szénatomos alkoxi)-(C=O)-, -CO2H, (1-6 szénatomos alkil)-NH-(C=O)- és[(1-6 szénatomos alkil)]2-N-(C=O)-csoport; Ar jelentése (6-10 szénatomos aril)-(1-6 szénatomos alkoxi)-6-10 szénatomos aril), (6-10 szénatomos aril)-(1-6 szénatomos alkoxi)-(2-9 szénatomosheteroaril), (2-9 szénatomos heteroaril)-(1-6 szénatomos alkoxi)-(6-10szénatomos aril), (2-9 szénatomos heteroaril)-(1-6 szénatomos alkoxi)-(2-9 szénatomos heteroaril) csoport, amelyek adott esetben egy vagyt"bb szubsztituenssel helyettesítettek. Ó
HU0103452A 1998-08-12 1999-08-05 Hydroxy pipecolate hydroxamic acid derivatives as mmp inhibitors and pharmaceutical compositions containing the compounds HUP0103452A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9623298P 1998-08-12 1998-08-12
PCT/IB1999/001388 WO2000009485A1 (en) 1998-08-12 1999-08-05 Hydroxy pipecolate hydroxamic acid derivatives as mmp inhibitors

Publications (2)

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HUP0103452A2 true HUP0103452A2 (hu) 2002-04-29
HUP0103452A3 HUP0103452A3 (en) 2002-10-28

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US (2) US6329397B1 (hu)
EP (1) EP1104403B1 (hu)
JP (1) JP2002522528A (hu)
KR (1) KR20010085374A (hu)
CN (1) CN1316995A (hu)
AP (1) AP2001002070A0 (hu)
AR (1) AR019241A1 (hu)
AT (1) ATE325791T1 (hu)
AU (1) AU766366B2 (hu)
BG (1) BG105323A (hu)
BR (1) BR9912909A (hu)
CA (1) CA2340202C (hu)
CZ (1) CZ2001484A3 (hu)
DE (1) DE69931266T2 (hu)
DZ (1) DZ2870A1 (hu)
EA (1) EA200100126A1 (hu)
EE (1) EE200100086A (hu)
ES (1) ES2263279T3 (hu)
GE (1) GEP20033117B (hu)
GT (1) GT199900131A (hu)
HK (1) HK1040242A1 (hu)
HN (1) HN1999000131A (hu)
HR (1) HRP20010098A2 (hu)
HU (1) HUP0103452A3 (hu)
ID (1) ID27840A (hu)
IL (1) IL141030A0 (hu)
IS (1) IS5813A (hu)
MA (1) MA26675A1 (hu)
NO (1) NO20010686L (hu)
NZ (1) NZ509296A (hu)
OA (1) OA11594A (hu)
PA (1) PA8479201A1 (hu)
PE (1) PE20000951A1 (hu)
PL (1) PL346041A1 (hu)
SK (1) SK1872001A3 (hu)
SV (1) SV1999000123A (hu)
TN (1) TNSN99156A1 (hu)
TR (1) TR200100474T2 (hu)
UA (1) UA59453C2 (hu)
UY (1) UY25993A1 (hu)
WO (1) WO2000009485A1 (hu)
YU (1) YU5201A (hu)
ZA (1) ZA200101042B (hu)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846799B1 (en) 1998-08-18 2005-01-25 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
US7354894B2 (en) 1998-08-18 2008-04-08 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
US6531488B1 (en) * 1998-08-31 2003-03-11 Merck & Co., Inc. Method of treating neurodegenerative diseases
US6509337B1 (en) * 1998-09-17 2003-01-21 Pfizer Inc. Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1081137A1 (en) * 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
EP1138680A1 (en) * 2000-03-29 2001-10-04 Pfizer Products Inc. Gem substituted sulfonyl hydroxamic acids as MMP inhibitors
JP2001322977A (ja) * 2000-05-12 2001-11-20 Kotobuki Seiyaku Kk ピペコリン酸誘導体及びその製造方法並びにこれを含有する医薬組成物
JP2002105073A (ja) * 2000-09-27 2002-04-10 Shionogi & Co Ltd 新規マトリックスメタロプロテアーゼ阻害剤
EP1368323B1 (en) 2001-02-14 2010-06-30 Warner-Lambert Company LLC Pyrimidine matrix metalloproteinase inhibitors
PA8539501A1 (es) 2001-02-14 2002-09-30 Warner Lambert Co Compuestos triazolo como inhibidores de mmp
DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
CA2462442A1 (en) 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkyne matrix metalloproteinase inhibitors
US6962922B2 (en) 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
KR20050013616A (ko) * 2002-06-26 2005-02-04 카나 바이오사이언스 인코포레이션 신규 아자당 유도체 및 이것을 유효성분으로 하는 약제
EP1525030A1 (en) * 2002-07-17 2005-04-27 Warner-Lambert Company LLC Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
MXPA05000476A (es) * 2002-07-17 2005-03-23 Warner Lambert Co Combinacion de un inhibidor alquino alosterico de metaloproteinasa-13 de matriz con celecoxib o valdecoxib.
CA2497658A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Chromone derivatives as matrix metalloproteinase inhibitors
WO2004014909A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
AU2003250466A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
JP2006500351A (ja) 2002-08-13 2006-01-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー マトリックスメタロプロテアーゼ−１３阻害剤としてのピリミジン−２，４−ジオン誘導体
AU2003249540A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Fused bicyclic metalloproteinase inhibitors
WO2004014923A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Pyrimidinone fused bicyclic metalloproteinase inhibitors
PA8578101A1 (es) 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
WO2004014908A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Heterobicylcic metalloproteinase inhibitors
BR0313459A (pt) 2002-08-13 2005-06-21 Warner Lambert Co Derivados monocìclicos como inibidores de metaloproteinases de matriz
AU2003249531A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
WO2006131836A2 (en) * 2005-03-22 2006-12-14 Innodia Inc. Compounds and compositions for use in the prevention and treatment of obesity and related syndromes
ATE494926T1 (de) 2008-03-25 2011-01-15 Affectis Pharmaceuticals Ag Neuartige p2x7r-antagonisten und ihre verwendung
MX2011010810A (es) 2009-04-14 2012-01-12 Affectis Pharmaceuticals Ag Nuevos antagonistas de p2x7r y su uso.
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
DE202016007195U1 (de) 2016-11-16 2017-11-17 Bernhard Kohler Strombegrenzende Schalteinrichtung
WO2020160140A1 (en) * 2019-01-29 2020-08-06 Darsha Llc Compositions and methods for treating pulmonary disease with matrix metalloproteinase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0821671T3 (da) * 1995-04-20 2001-04-23 Pfizer Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
US6153757A (en) * 1995-12-08 2000-11-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors and intermediates useful for their preparation
WO1998008815A1 (en) * 1996-08-28 1998-03-05 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
PT977733E (pt) * 1997-02-03 2003-12-31 Pfizer Prod Inc Derivados de acido arilsulfonilamino-hidroxamico
BR9807678A (pt) * 1997-02-11 2000-02-15 Pfizer Derivados de ácidos arilsulfonil-hidroxâmicos
WO1998050348A1 (en) * 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses

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