HUP0102975A2 - Kemotaxis-gátló Staphylococcus protein (CHIPS) és annak alkalmazása - Google Patents
Kemotaxis-gátló Staphylococcus protein (CHIPS) és annak alkalmazásaInfo
- Publication number
- HUP0102975A2 HUP0102975A2 HU0102975A HUP0102975A HUP0102975A2 HU P0102975 A2 HUP0102975 A2 HU P0102975A2 HU 0102975 A HU0102975 A HU 0102975A HU P0102975 A HUP0102975 A HU P0102975A HU P0102975 A2 HUP0102975 A2 HU P0102975A2
- Authority
- HU
- Hungary
- Prior art keywords
- chips
- protein
- staphylococcus
- chemotaxis
- relates
- Prior art date
Links
- 241000191940 Staphylococcus Species 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 230000035605 chemotaxis Effects 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 101710191541 Chemotaxis inhibitory protein Proteins 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- PRQROPMIIGLWRP-UHFFFAOYSA-N N-formyl-methionyl-leucyl-phenylalanin Chemical compound CSCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(C(O)=O)CC1=CC=CC=C1 PRQROPMIIGLWRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000005482 chemotactic factor Substances 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000003714 granulocyte Anatomy 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Unknown Constitution (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A találmány kemotaxist gátló hatású Staphylococcus fehérjére és annakbiológiailag aktív fragmenseire vonatkozik, amelyek akut és krónikusgyulladásos reakciók és a HIV fertőzés kezelésében való használatraalkalmasak. A találmány szerinti protein molekulatömege mintegy 17 kD,N-terminális aminosav-szekvenciája az 1. szekvencia és biológiaiaktivitása folytán képes megakadályozni kemotaktikus faktorok,különösen az fMLP és/vagy a C5a megkötődését a granulocitákon. Atalálmány tárgyát képezik olyan gyógyászati készítmények, amelyekgyógyászati szempontból elfogadható vivőanyagok mellett hatóanyagkéntilyen CHIPS proteint tartalmaznak. A találmány tárgyát képezik továbbáaz említett CHIPS proteinek elleni antitestek, valamint az ilyenantitesteket hatóanyagként tartalmazó gyógyászati készítmények,amelyek Staphylococcus fertőzések kezelésére használhatók. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1009614 | 1998-07-10 | ||
PCT/NL1999/000442 WO2000002913A1 (en) | 1998-07-10 | 1999-07-12 | Chemotaxis-inhibiting protein of staphylococcus (chips) and its use |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0102975A2 true HUP0102975A2 (hu) | 2001-11-28 |
Family
ID=19767471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102975A HUP0102975A2 (hu) | 1998-07-10 | 1999-07-12 | Kemotaxis-gátló Staphylococcus protein (CHIPS) és annak alkalmazása |
Country Status (22)
Country | Link |
---|---|
US (2) | US20050143307A1 (hu) |
EP (1) | EP1095059B1 (hu) |
JP (1) | JP2002520336A (hu) |
KR (1) | KR20010053290A (hu) |
CN (1) | CN1309662A (hu) |
AT (1) | ATE328898T1 (hu) |
AU (1) | AU4935999A (hu) |
BG (1) | BG105120A (hu) |
BR (1) | BR9911944A (hu) |
CA (1) | CA2333898A1 (hu) |
CY (1) | CY1105343T1 (hu) |
DE (1) | DE69931784T2 (hu) |
DK (1) | DK1095059T3 (hu) |
ES (1) | ES2270609T3 (hu) |
HU (1) | HUP0102975A2 (hu) |
IL (1) | IL140768A0 (hu) |
NO (1) | NO20010140L (hu) |
NZ (1) | NZ509051A (hu) |
PL (1) | PL345452A1 (hu) |
PT (1) | PT1095059E (hu) |
WO (1) | WO2000002913A1 (hu) |
ZA (1) | ZA200100092B (hu) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1309662A (zh) * | 1998-07-10 | 2001-08-22 | 亚利制药有限公司 | 葡萄球菌属的趋化性抑制蛋白(chips)及其应用 |
EP1118663A1 (en) * | 2000-01-07 | 2001-07-25 | Universiteit Utrecht | Nucleic acids encoding chemotaxis inhibitory polypeptides |
US20020086292A1 (en) | 2000-12-22 | 2002-07-04 | Shigeaki Harayama | Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules |
WO2003006048A1 (en) * | 2001-07-11 | 2003-01-23 | Jari Pharmaceuticals B.V. | Combination of chips (chemotaxis inhibiting protein from staphylococcus aureus)-based compounds |
DE602004031836D1 (de) * | 2003-07-08 | 2011-04-28 | Umc Utrecht Holding Bv | Therapeutische verwendung von lpi, einem inhibitor des lectinwegs in staphylokokken bei entzündungskrankheiten |
EP1586583A3 (en) * | 2004-04-16 | 2005-11-16 | Alligator Bioscience AB (publ) | Compounds that block C5a complement receptor and their use in therapy |
US20090186111A1 (en) | 2004-07-26 | 2009-07-23 | Zeev Trainin | Novel Bacteria and Pharmaceutically Active Products Obtained Therefrom |
GB2432366B (en) * | 2005-11-19 | 2007-11-21 | Alligator Bioscience Ab | A method for in vitro molecular evolution of protein function |
GB0607798D0 (en) | 2006-04-20 | 2006-05-31 | Alligator Bioscience Ab | Novel polypeptides and use thereof |
GB0905790D0 (en) | 2009-04-03 | 2009-05-20 | Alligator Bioscience Ab | Novel polypeptides and use thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4772584A (en) * | 1986-05-23 | 1988-09-20 | Cleary Paul P | Inhibitor of C5a-mediated chemotaxis |
AU2509592A (en) * | 1991-08-22 | 1993-03-16 | Washington University | Polynucleotide probes for salmonella |
US5514555A (en) * | 1993-03-12 | 1996-05-07 | Center For Blood Research, Inc. | Assays and therapeutic methods based on lymphocyte chemoattractants |
US5514455A (en) * | 1994-07-08 | 1996-05-07 | Union Carbide Chemicals & Plastics Technology Corporation | Film extruded from an in situ blend of ethylene copolymers |
US5817476A (en) * | 1995-06-07 | 1998-10-06 | Genetics Institute, Inc. | Polynucleotides encoding interleukin-1 receptor intracellular ligand proteins |
US7153655B2 (en) * | 1998-06-16 | 2006-12-26 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence |
CN1309662A (zh) * | 1998-07-10 | 2001-08-22 | 亚利制药有限公司 | 葡萄球菌属的趋化性抑制蛋白(chips)及其应用 |
JP3722194B2 (ja) * | 1999-05-20 | 2005-11-30 | セイコーエプソン株式会社 | 画像表示システム |
EP1118663A1 (en) * | 2000-01-07 | 2001-07-25 | Universiteit Utrecht | Nucleic acids encoding chemotaxis inhibitory polypeptides |
US6958213B2 (en) * | 2000-12-12 | 2005-10-25 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function |
US20020086292A1 (en) * | 2000-12-22 | 2002-07-04 | Shigeaki Harayama | Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules |
WO2003097834A2 (en) * | 2002-05-17 | 2003-11-27 | Alligator Bioscience Ab | A method for in vitro molecular evolution of protein function |
-
1999
- 1999-07-12 CN CN99808416A patent/CN1309662A/zh active Pending
- 1999-07-12 WO PCT/NL1999/000442 patent/WO2000002913A1/en active IP Right Grant
- 1999-07-12 PT PT99933284T patent/PT1095059E/pt unknown
- 1999-07-12 BR BR9911944-7A patent/BR9911944A/pt not_active IP Right Cessation
- 1999-07-12 AT AT99933284T patent/ATE328898T1/de not_active IP Right Cessation
- 1999-07-12 DE DE69931784T patent/DE69931784T2/de not_active Expired - Lifetime
- 1999-07-12 JP JP2000559142A patent/JP2002520336A/ja active Pending
- 1999-07-12 NZ NZ509051A patent/NZ509051A/xx unknown
- 1999-07-12 IL IL14076899A patent/IL140768A0/xx unknown
- 1999-07-12 ES ES99933284T patent/ES2270609T3/es not_active Expired - Lifetime
- 1999-07-12 AU AU49359/99A patent/AU4935999A/en not_active Abandoned
- 1999-07-12 EP EP99933284A patent/EP1095059B1/en not_active Expired - Lifetime
- 1999-07-12 HU HU0102975A patent/HUP0102975A2/hu unknown
- 1999-07-12 PL PL99345452A patent/PL345452A1/xx unknown
- 1999-07-12 CA CA002333898A patent/CA2333898A1/en not_active Abandoned
- 1999-07-12 KR KR1020007015012A patent/KR20010053290A/ko not_active Application Discontinuation
- 1999-07-12 DK DK99933284T patent/DK1095059T3/da active
-
2001
- 2001-01-04 ZA ZA200100092A patent/ZA200100092B/en unknown
- 2001-01-08 BG BG105120A patent/BG105120A/xx unknown
- 2001-01-09 NO NO20010140A patent/NO20010140L/no unknown
-
2005
- 2005-02-22 US US11/063,324 patent/US20050143307A1/en not_active Abandoned
-
2006
- 2006-09-06 CY CY20061101273T patent/CY1105343T1/el unknown
-
2007
- 2007-03-27 US US11/691,745 patent/US20080242605A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR9911944A (pt) | 2001-09-25 |
NO20010140D0 (no) | 2001-01-09 |
NZ509051A (en) | 2003-01-31 |
JP2002520336A (ja) | 2002-07-09 |
DK1095059T3 (da) | 2006-10-02 |
NO20010140L (no) | 2001-03-01 |
PL345452A1 (en) | 2001-12-17 |
DE69931784T2 (de) | 2007-06-14 |
DE69931784D1 (de) | 2006-07-20 |
AU4935999A (en) | 2000-02-01 |
WO2000002913B1 (en) | 2000-03-30 |
BG105120A (en) | 2001-11-30 |
US20080242605A1 (en) | 2008-10-02 |
CY1105343T1 (el) | 2010-03-03 |
KR20010053290A (ko) | 2001-06-25 |
EP1095059B1 (en) | 2006-06-07 |
IL140768A0 (en) | 2002-02-10 |
ES2270609T3 (es) | 2007-04-01 |
EP1095059A1 (en) | 2001-05-02 |
PT1095059E (pt) | 2006-10-31 |
US20050143307A1 (en) | 2005-06-30 |
ATE328898T1 (de) | 2006-06-15 |
CA2333898A1 (en) | 2000-01-20 |
ZA200100092B (en) | 2001-07-23 |
CN1309662A (zh) | 2001-08-22 |
WO2000002913A1 (en) | 2000-01-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE389724T1 (de) | Menschliche dnase i hyperaktive varianten | |
DE59905954D1 (de) | Dialkylfumarate zur behandlung von autoimmunerkrankungen | |
ES2130574T3 (es) | Agentes de restriccion de las citoquinas. | |
ATE309271T1 (de) | Zusammensetzungen von kollagenbindungsprotein und verfahren zur deren verwendungen | |
IL134830A0 (en) | Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them | |
ES2163444T3 (es) | Composiciones y metodos para la administracion oral de farmacos. | |
Mitani et al. | Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses. | |
RU98120519A (ru) | Аутоантиген и структурно-родственные ему белки для применения при иммунотерапии аутоиммунных заболеваний | |
CY1105008T1 (el) | Αντιμικροβιακη ενεργοτητα του πρωτου κατιονικου συγκροτηματος της ανθρωπινης λακτοφερρινης | |
HUP0001136A2 (hu) | Limfatikus tumorok kezelésére szolgáló gyógyszerkészítmények | |
HUP0102975A2 (hu) | Kemotaxis-gátló Staphylococcus protein (CHIPS) és annak alkalmazása | |
PT1079849E (pt) | Utilizacao de proteinas hmg para a preparacao de medicamentos com actividade citotoxica | |
RU2001132140A (ru) | Рекомбинантный рецептор коллагена на тромбоцитах гликопротеин VI и его применение в фармацевтике | |
LTIP1753A (en) | Dna sequences coding for proteins, biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins | |
CA2306441A1 (fr) | Peptides issus de gene env du virus de l'immunodeficience feline et leurs applications | |
ATE395064T1 (de) | Kombinationspräparate von 3-n- formylhydroxylaminopropylphosphonsäurederivaten oder 3-n- acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen | |
BG103905A (en) | New bpc peptide salts with organoprotective activity, method for their preparation and application in medicine | |
IL145403A0 (en) | Fragments of virus protein 2 or 3 of the polyoma virus, use for transporting active ingredients | |
FR2694938B1 (fr) | Nouveaux peptides, anticorps diriges contre ces peptides, anticorps anti-idiotypiques, application a titre de medicaments, compositions pharmaceutiques et kits de diagnostic les renfermant. | |
DK0811068T3 (da) | Humane DNase I varianter | |
RU95105249A (ru) | Гидрохлорид ng монометил-l-аргинина, способы его получения, способ получения фармацевтического препарата и способ лечения | |
FI961505A0 (fi) | Uudet veren koaguloitumisjärjestelmässä terapeuttisesti aktiiviset peptidiyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset | |
ATE282704T1 (de) | Isolierte und gereinigte humane lösliche guanylylcyclase alpha1/beta1 (hsgc alpha1/beta1) | |
FR2792639B1 (fr) | Nouveaux immunogenes anti-vih (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida | |
Ryden | Studies on interactions between staphylococcal cells and some connective tissue components. |