HUP0002859A2 - A nitrogén-monoxidot kibocsátó vegyületek alkalmazása rinovírus-fertőzés által előidézett kórtünetek enyhítésére - Google Patents

A nitrogén-monoxidot kibocsátó vegyületek alkalmazása rinovírus-fertőzés által előidézett kórtünetek enyhítésére

Info

Publication number
HUP0002859A2
HUP0002859A2 HU0002859A HUP0002859A HUP0002859A2 HU P0002859 A2 HUP0002859 A2 HU P0002859A2 HU 0002859 A HU0002859 A HU 0002859A HU P0002859 A HUP0002859 A HU P0002859A HU P0002859 A2 HUP0002859 A2 HU P0002859A2
Authority
HU
Hungary
Prior art keywords
nitric oxide
rhinovirus
subject
rhinovirus infection
replication
Prior art date
Application number
HU0002859A
Other languages
English (en)
Inventor
David Proud
Scherer P. Sanders
Original Assignee
The Johns Hopkins University School Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns Hopkins University School Of Medicine filed Critical The Johns Hopkins University School Of Medicine
Publication of HUP0002859A2 publication Critical patent/HUP0002859A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Atalálmány tárgya nitrogén-monoxidot (NO-t) kibocsátó vegyület,valamint humán légúti epitélsejtek nitrogén-oxid-szintázát (NOS-t)indukáló vegyület alkalmazása rinovírus-fertőzés által előidézettkórtünetek enyhítésére alkalmas gyógyászati készítmény előállítására.Atalálmány tárgya továbbá eljárás rinovírus-replikáció és rinovírusáltal előidézett citokintermelődés mértékének csökkentésére.Atalálmány tárgyát képezik továbbá eljárások vegyületek tesztelésérerinovírus-fertőzés kezelésére való alkalmasság szempontjából, továbbáorrpermetező, cseppentőüveg, inhaláló- és porlasztókészülék. Anitrogén-oxid képes gátolni rinovírusok replikációját és - különösen agyulladáskeltő - citokinek képződését egyaránt. Ennélfogva arinovírus-fertőzések kórtünetei enyhíthetők a légutakban végzett,nitrogén-oxid-koncentráció növekedését eredményező kezeléssel. Ó
HU0002859A 1997-07-11 1998-07-10 A nitrogén-monoxidot kibocsátó vegyületek alkalmazása rinovírus-fertőzés által előidézett kórtünetek enyhítésére HUP0002859A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5230797P 1997-07-11 1997-07-11

Publications (1)

Publication Number Publication Date
HUP0002859A2 true HUP0002859A2 (hu) 2001-01-29

Family

ID=21976738

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002859A HUP0002859A2 (hu) 1997-07-11 1998-07-10 A nitrogén-monoxidot kibocsátó vegyületek alkalmazása rinovírus-fertőzés által előidézett kórtünetek enyhítésére

Country Status (14)

Country Link
US (1) US6277891B1 (hu)
EP (1) EP1011657A1 (hu)
JP (1) JP2001509481A (hu)
KR (1) KR20010021749A (hu)
CN (1) CN1277552A (hu)
AU (1) AU8399098A (hu)
BR (1) BR9811473A (hu)
CA (1) CA2303430A1 (hu)
CZ (1) CZ200092A3 (hu)
HU (1) HUP0002859A2 (hu)
ID (1) ID23780A (hu)
NO (1) NO20000151L (hu)
TR (1) TR200000157T2 (hu)
WO (1) WO1999002148A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030753A1 (es) * 2000-09-25 2003-09-03 Smithkline Beecham Corp Uso de moduladores-proteina de il-8, groalfa, grobeta, grogamma, nap-2, y ena-78, para tratar infecciones viricas
GB0125222D0 (en) * 2001-10-19 2001-12-12 Barts & London Nhs Trust Composition for the treatment of microbial infections
DE10303196A1 (de) * 2003-01-28 2004-08-12 Märtz, Hans Helmut Verwendung von Erzeugnissen, Stoffen oder Stoffgemischen, aus welchen im menschlichen oder tierischen Körper Stickoxid (Formel: NO) entsteht, zur Behandlung oder Prophylaxe von Infektionskrankheiten des menschlichen oder tierischen Körpers
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
AU2004255268B2 (en) 2003-07-09 2010-04-01 Loma Linda University Use of nitrite salts for the treatment of cardiovascular conditions
US8252591B2 (en) * 2004-05-07 2012-08-28 Whitehead Institute For Biomedical Research Hormone responsive tissue culture system and uses thereof
US7362274B1 (en) * 2004-07-09 2008-04-22 Huan-Cheng Lien Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna
US8557300B2 (en) 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
GB0607402D0 (en) * 2006-04-12 2006-05-24 Barts & London Nhs Trust Therapeutic composition and use
EP2188367A4 (en) 2007-08-10 2010-10-27 Whitehead Biomedical Inst HORMONE REACTIVE TISSUE CULTURE SYSTEM, AND USES THEREOF
EP2237788A4 (en) * 2007-12-27 2013-06-05 Aires Pharmaceuticals Inc COMPOUNDS FOR OBTAINING AEROSOLIZED NITRITE AND NITRIC OXIDE AND USES THEREOF
JP5558458B2 (ja) * 2008-03-20 2014-07-23 タノメド・アクチボラゲット 普通感冒の治療用の医薬の製造における物質の使用
US11850283B2 (en) * 2017-06-27 2023-12-26 Ohio State Innovation Foundation Liponucleotide-based therapy for asthma
CN109432122A (zh) * 2018-11-19 2019-03-08 罗辉 No或no供体在制备预防和/或治疗皮肤疾病或黏膜疾病药物中的应用及药物组合物
CN109846113A (zh) * 2018-11-29 2019-06-07 南京诺全生物医疗科技有限公司 一种可自提供一氧化氮的口鼻卫生用品

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455279A (en) * 1991-04-19 1995-10-03 The Children's Medical Center Corporation Regimen method of mediating neuronal damage using nitroglycerine

Also Published As

Publication number Publication date
KR20010021749A (ko) 2001-03-15
WO1999002148A1 (en) 1999-01-21
CZ200092A3 (en) 2001-05-16
ID23780A (id) 2000-05-11
TR200000157T2 (tr) 2001-06-21
EP1011657A1 (en) 2000-06-28
BR9811473A (pt) 2001-12-26
AU8399098A (en) 1999-02-08
US6277891B1 (en) 2001-08-21
CA2303430A1 (en) 1999-01-21
JP2001509481A (ja) 2001-07-24
NO20000151D0 (no) 2000-01-11
NO20000151L (no) 2000-03-09
CN1277552A (zh) 2000-12-20

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