HUE071685T2 - Tiadiazolon-származékok és alkalmazásuk AMPK agonistákként diabétesz és kapcsolódó rendellenességek kezelésében - Google Patents

Tiadiazolon-származékok és alkalmazásuk AMPK agonistákként diabétesz és kapcsolódó rendellenességek kezelésében

Info

Publication number
HUE071685T2
HUE071685T2 HUE21816508A HUE21816508A HUE071685T2 HU E071685 T2 HUE071685 T2 HU E071685T2 HU E21816508 A HUE21816508 A HU E21816508A HU E21816508 A HUE21816508 A HU E21816508A HU E071685 T2 HUE071685 T2 HU E071685T2
Authority
HU
Hungary
Prior art keywords
thiadiazolone
diabetes
derivatives
treatment
related disorders
Prior art date
Application number
HUE21816508A
Other languages
English (en)
Hungarian (hu)
Inventor
Thomas Edlund
Jacob Westman
Original Assignee
Betagenon Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Betagenon Ab filed Critical Betagenon Ab
Publication of HUE071685T2 publication Critical patent/HUE071685T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/081,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539Five-membered rings
    • C07F9/65392Five-membered rings containing two nitrogen atoms
    • C07F9/65397Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HUE21816508A 2020-10-01 2021-09-30 Tiadiazolon-származékok és alkalmazásuk AMPK agonistákként diabétesz és kapcsolódó rendellenességek kezelésében HUE071685T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2015585.9A GB202015585D0 (en) 2020-10-01 2020-10-01 New compounds

Publications (1)

Publication Number Publication Date
HUE071685T2 true HUE071685T2 (hu) 2025-09-28

Family

ID=73223766

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE21816508A HUE071685T2 (hu) 2020-10-01 2021-09-30 Tiadiazolon-származékok és alkalmazásuk AMPK agonistákként diabétesz és kapcsolódó rendellenességek kezelésében

Country Status (13)

Country Link
US (1) US20230382930A1 (https=)
EP (1) EP4222147B1 (https=)
JP (1) JP7793614B2 (https=)
KR (1) KR20230079163A (https=)
CN (1) CN116368141B (https=)
AU (1) AU2021352146A1 (https=)
CA (1) CA3193947A1 (https=)
ES (1) ES3018732T3 (https=)
GB (1) GB202015585D0 (https=)
HU (1) HUE071685T2 (https=)
MX (1) MX2023003825A (https=)
PL (1) PL4222147T3 (https=)
WO (1) WO2022069894A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11691954B2 (en) 2019-10-18 2023-07-04 Betagenon Ab Formulations
GB202112529D0 (en) * 2021-09-02 2021-10-20 Betagenon Bio Ab New compounds
EP4600642A1 (en) * 2022-10-05 2025-08-13 Sawai Pharmaceutical Co., Ltd. Method for selecting additive capable of inhibiting nitrosation reaction, and preparation prevented from generation of nitroso compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5982281B2 (ja) * 2009-07-08 2016-08-31 バルティック バイオ アーベー 医薬として有用な化合物
WO2013108026A1 (en) * 2012-01-17 2013-07-25 Baltic Bio Ab Thiadiazolone derivatives useful in the treatment of diabetes
AU2018448511B2 (en) * 2018-11-05 2025-07-03 Betagenon Ab Methods of treating diabetes in severe insulin-resistant diabetic subjects

Also Published As

Publication number Publication date
CA3193947A1 (en) 2022-04-07
JP7793614B2 (ja) 2026-01-05
CN116368141A (zh) 2023-06-30
ES3018732T3 (en) 2025-05-19
PL4222147T3 (pl) 2025-06-09
EP4222147C0 (en) 2025-03-19
JP2023543924A (ja) 2023-10-18
EP4222147A1 (en) 2023-08-09
AU2021352146A1 (en) 2023-06-01
MX2023003825A (es) 2023-06-06
EP4222147B1 (en) 2025-03-19
GB202015585D0 (en) 2020-11-18
WO2022069894A1 (en) 2022-04-07
KR20230079163A (ko) 2023-06-05
US20230382930A1 (en) 2023-11-30
CN116368141B (zh) 2025-09-23

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