HUE066487T2 - Regorafenib és nivolumab kombinációja rák kezelésére - Google Patents

Regorafenib és nivolumab kombinációja rák kezelésére

Info

Publication number
HUE066487T2
HUE066487T2 HUE18725258A HUE18725258A HUE066487T2 HU E066487 T2 HUE066487 T2 HU E066487T2 HU E18725258 A HUE18725258 A HU E18725258A HU E18725258 A HUE18725258 A HU E18725258A HU E066487 T2 HUE066487 T2 HU E066487T2
Authority
HU
Hungary
Prior art keywords
regorafenib
nivolumab
combination
treating cancer
cancer
Prior art date
Application number
HUE18725258A
Other languages
English (en)
Inventor
Sabine Hoff
Lars Roese
Dieter Zopf
Fabian Kiessling
Wiltrud Lederle
Dennis Doleschel
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of HUE066487T2 publication Critical patent/HUE066487T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HUE18725258A 2017-06-02 2018-05-25 Regorafenib és nivolumab kombinációja rák kezelésére HUE066487T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17174169 2017-06-02

Publications (1)

Publication Number Publication Date
HUE066487T2 true HUE066487T2 (hu) 2024-08-28

Family

ID=58992733

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE18725258A HUE066487T2 (hu) 2017-06-02 2018-05-25 Regorafenib és nivolumab kombinációja rák kezelésére

Country Status (21)

Country Link
US (4) US11951166B2 (hu)
EP (2) EP3630112B9 (hu)
JP (3) JP7303122B2 (hu)
KR (2) KR102673422B1 (hu)
CN (3) CN117899212A (hu)
AU (2) AU2018276273B2 (hu)
BR (1) BR112019025478A8 (hu)
CA (1) CA3065125A1 (hu)
DK (1) DK3630112T3 (hu)
ES (1) ES2978337T3 (hu)
FI (1) FI3630112T3 (hu)
HR (1) HRP20240551T1 (hu)
HU (1) HUE066487T2 (hu)
IL (1) IL270948A (hu)
LT (1) LT3630112T (hu)
MX (1) MX2023001721A (hu)
PL (1) PL3630112T3 (hu)
PT (1) PT3630112T (hu)
RS (1) RS65488B9 (hu)
SI (1) SI3630112T1 (hu)
WO (1) WO2018219807A1 (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3630112T (lt) * 2017-06-02 2024-05-10 Bayer Healthcare Llc Regorafenibo ir nivolumabo derinys, skirtas vėžio gydymui
CN111001004A (zh) * 2019-10-08 2020-04-14 广州医科大学附属第二医院 一种治疗肝癌的药物组合及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52625B (en) 2003-07-23 2013-06-28 Bayer Healthcare Llc FLUORO SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR TREATMENT AND PREVENTION OF DISEASES AND DISEASES
EP1948144A2 (en) 2005-11-10 2008-07-30 Bayer HealthCare AG Diaryl urea for treating diabetic neuropathy
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
AR092439A1 (es) * 2012-09-06 2015-04-22 Bayer Healthcare Llc Composicion farmaceutica recubierta que contiene regorafenib
CA2885688C (en) 2012-09-25 2021-03-02 Bayer Pharma Aktiengesellschaft Combination of regorafenib and acetylsalicylic acid for treating cancer
JP5653489B1 (ja) 2013-07-24 2015-01-14 三菱エンジニアリングプラスチックス株式会社 薄肉光学部材用ポリカーボネート樹脂ペレット及びその製造方法
HUE041469T2 (hu) 2014-02-04 2019-05-28 Pfizer PD-1 antagonista és VEGFR inhibitor kombinációja rák kezelésére
ES2808728T3 (es) 2014-02-21 2021-03-01 Idac Theranostics Inc Agente terapéutico para cáncer sólido
SG10202007111TA (en) * 2014-07-15 2020-09-29 Genentech Inc Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
WO2016010879A1 (en) 2014-07-15 2016-01-21 The Johns Hopkins University Suppression of myeloid derived suppressor cells and immune checkpoint blockade
EP3192517A4 (en) * 2014-08-19 2018-04-25 National University Corporation Okayama University Method for enhancing immune cell function and method for assessing immune cell multifunctionality
JP2017535528A (ja) * 2014-10-03 2017-11-30 ノバルティス アーゲー 組み合わせ治療
KR20220054710A (ko) 2014-11-13 2022-05-03 더 존스 홉킨스 유니버시티 관문 차단 및 미소부수체 불안정성
WO2016173959A1 (en) * 2015-04-28 2016-11-03 Bayer Pharma Aktiengesellschaft Regorafenib for treating colorectal cancer
US20190022092A1 (en) 2015-09-15 2019-01-24 Acerta Pharma B.V. Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist
EP3463456A1 (en) 2016-06-03 2019-04-10 ImClone LLC Combination of ramucirumab and pembrolizumab for the treatment of certain cancers
US10251888B2 (en) 2016-06-13 2019-04-09 Chemocentryx, Inc. Method of treating pancreatic cancer
LT3630112T (lt) 2017-06-02 2024-05-10 Bayer Healthcare Llc Regorafenibo ir nivolumabo derinys, skirtas vėžio gydymui
KR102692379B1 (ko) * 2017-06-05 2024-08-05 얀센 바이오테크 인코포레이티드 Pd-1과 특이적으로 결합하는 항체 및 사용 방법

Also Published As

Publication number Publication date
EP4342542A2 (en) 2024-03-27
CA3065125A1 (en) 2018-12-06
JP7303122B2 (ja) 2023-07-04
FI3630112T3 (fi) 2024-05-02
EP3630112A1 (en) 2020-04-08
US11951166B2 (en) 2024-04-09
ES2978337T3 (es) 2024-09-10
WO2018219807A1 (en) 2018-12-06
CN117899212A (zh) 2024-04-19
US20200179354A1 (en) 2020-06-11
EP3630112B1 (en) 2024-01-31
KR102673422B1 (ko) 2024-06-07
BR112019025478A8 (pt) 2022-12-06
RS65488B9 (sr) 2024-09-30
RS65488B1 (sr) 2024-05-31
IL270948A (en) 2020-01-30
BR112019025478A2 (pt) 2020-06-23
CN117582495A (zh) 2024-02-23
RU2019143599A3 (hu) 2021-09-10
PL3630112T3 (pl) 2024-07-01
MX2023001721A (es) 2023-02-22
EP4342542A3 (en) 2024-06-05
EP3630112B9 (en) 2024-06-26
US20200155674A1 (en) 2020-05-21
CN110662540A (zh) 2020-01-07
DK3630112T3 (da) 2024-04-22
CN110662540B (zh) 2024-01-26
AU2023282197A1 (en) 2024-01-04
PT3630112T (pt) 2024-04-23
HRP20240551T1 (hr) 2024-07-05
JP2024096905A (ja) 2024-07-17
AU2018276273B2 (en) 2023-12-21
JP2022169780A (ja) 2022-11-09
JP2020521786A (ja) 2020-07-27
RU2019143599A (ru) 2021-07-09
KR20200011971A (ko) 2020-02-04
JP7475402B2 (ja) 2024-04-26
AU2018276273A1 (en) 2019-12-12
US11517622B2 (en) 2022-12-06
SI3630112T1 (sl) 2024-06-28
US20220133888A1 (en) 2022-05-05
KR20240091188A (ko) 2024-06-21
US20200188372A1 (en) 2020-06-18
LT3630112T (lt) 2024-05-10

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