HUE055832T2 - Virulenciájában gyengített baktériumokon alapuló fehérjeszállítás - Google Patents
Virulenciájában gyengített baktériumokon alapuló fehérjeszállításInfo
- Publication number
- HUE055832T2 HUE055832T2 HUE17837961A HUE17837961A HUE055832T2 HU E055832 T2 HUE055832 T2 HU E055832T2 HU E17837961 A HUE17837961 A HU E17837961A HU E17837961 A HUE17837961 A HU E17837961A HU E055832 T2 HUE055832 T2 HU E055832T2
- Authority
- HU
- Hungary
- Prior art keywords
- based protein
- protein delivery
- attenuated bacteria
- bacteria based
- virulence attenuated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16205439 | 2016-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE055832T2 true HUE055832T2 (hu) | 2021-12-28 |
Family
ID=57629346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17837961A HUE055832T2 (hu) | 2016-12-20 | 2017-12-20 | Virulenciájában gyengített baktériumokon alapuló fehérjeszállítás |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US11518789B2 (hu) |
| EP (2) | EP3957645A1 (hu) |
| JP (1) | JP6976351B2 (hu) |
| KR (1) | KR102569949B1 (hu) |
| CN (1) | CN110325545B (hu) |
| AU (1) | AU2017384611B2 (hu) |
| BR (1) | BR112019012338A2 (hu) |
| CA (1) | CA3046852A1 (hu) |
| CL (1) | CL2019001698A1 (hu) |
| CO (1) | CO2019006675A2 (hu) |
| CY (1) | CY1124488T1 (hu) |
| DK (1) | DK3559022T3 (hu) |
| EA (1) | EA201991157A1 (hu) |
| ES (1) | ES2886672T3 (hu) |
| HR (1) | HRP20211516T1 (hu) |
| HU (1) | HUE055832T2 (hu) |
| IL (1) | IL267346A (hu) |
| LT (1) | LT3559022T (hu) |
| MA (1) | MA47119B1 (hu) |
| MX (1) | MX2019007264A (hu) |
| MY (1) | MY192537A (hu) |
| NZ (1) | NZ754510A (hu) |
| PE (1) | PE20191356A1 (hu) |
| PH (1) | PH12019550092A1 (hu) |
| PL (1) | PL3559022T3 (hu) |
| PT (1) | PT3559022T (hu) |
| RS (1) | RS62303B1 (hu) |
| SI (1) | SI3559022T1 (hu) |
| WO (1) | WO2018115140A2 (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201692025A1 (ru) | 2014-05-21 | 2017-05-31 | Университет Базель | Доставка белков, осуществляемая на основе бактерий |
| US11166987B2 (en) | 2015-11-19 | 2021-11-09 | Universitaet Basel | Virulence attenuated bacteria for treatment of malignant solid tumors |
| SI3377634T1 (sl) | 2015-11-19 | 2021-01-29 | Universitaet Basel | Dostava na bakterijah osnovanih proteinov |
| WO2017123675A1 (en) | 2016-01-11 | 2017-07-20 | Synlogic, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
| BR112019012338A2 (pt) | 2016-12-20 | 2019-11-26 | Univ Basel | liberação de proteína à base de bactérias de virulência atenuada |
| CA3110870A1 (en) * | 2018-09-06 | 2020-03-12 | Dana-Farber Cancer Institute, Inc. | Cgas/dncv-like nucleotidyltransferases and uses thereof |
| CN109825464B (zh) * | 2019-01-17 | 2021-06-15 | 浙江海洋大学 | 敲除t6ss-1基因簇的杀香鱼假单胞菌鱼用减毒疫苗 |
| US20220362361A1 (en) * | 2019-10-18 | 2022-11-17 | University Of Virginia Patent Foundation | Compositions and methods for producing enhanced immune responses and rapid antibody production |
| WO2022067219A1 (en) * | 2020-09-28 | 2022-03-31 | The Regents Of The University Of Michigan | Methods and compositions for intestinal inflammation |
| CN116802196A (zh) * | 2020-10-27 | 2023-09-22 | T3制药股份公司 | 基于细菌的蛋白质递送 |
| WO2022164937A1 (en) * | 2021-01-26 | 2022-08-04 | Christopher Bradley | Treatment of cancer using mrna-mediated virus vaccination antigens delivered by attenuated bacteria |
| CN112852698B (zh) * | 2021-01-30 | 2022-11-29 | 军事科学院军事医学研究院军事兽医研究所 | 牛种布鲁氏菌A19株asd基因缺失株的构建方法和应用 |
| AU2022244124A1 (en) * | 2021-03-25 | 2023-11-09 | T3 Pharmaceuticals Ag | Pharmaceutical combinations for treating cancer |
| CN117425671A (zh) * | 2021-03-25 | 2024-01-19 | T3制药股份公司 | 用于治疗癌症的药物组合 |
| CN113480611B (zh) * | 2021-06-28 | 2022-12-02 | 武汉大学 | Rig-i的半胱天冬酶激活募集结构域抗病毒多肽、载体及其在制备抗病毒药物中的应用 |
| CN113699088B (zh) * | 2021-08-27 | 2023-09-15 | 集美大学 | 一株溶藻弧菌pstS基因稳定沉默菌株及其应用 |
| CN114181881A (zh) * | 2021-12-15 | 2022-03-15 | 浙江农林大学 | 基于氨基酸改造的新型减毒单增李斯特菌构建方法及应用 |
| WO2023164454A2 (en) * | 2022-02-22 | 2023-08-31 | Board Of Regents For The Oklahoma Agricultural And Mechanical Colleges | Compositions and methods for improved rhizobium-mediated plant transformation |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965381A (en) * | 1998-03-06 | 1999-10-12 | Ludwig Institute For Cancer Research | Delivery of proteins into eukaryotic cells with recombinant yersinia |
| AU5209399A (en) | 1998-07-10 | 2000-02-01 | Cornell Research Foundation Inc. | Recombinant constructs and systems for secretion of proteins via type iii secretion systems |
| US6291245B1 (en) * | 1998-07-15 | 2001-09-18 | Roche Diagnostics Gmbh | Host-vector system |
| WO2002026819A2 (en) * | 2000-09-26 | 2002-04-04 | Roger Williams Hospital | Recombinant bcg vaccines for the prevention and treatment of cancer |
| WO2002077249A2 (en) | 2001-03-26 | 2002-10-03 | Universite Catholique De Louvain | Type iii bacterial strains for use in medicine |
| FR2862312B1 (fr) | 2003-11-13 | 2006-02-17 | Univ Grenoble 1 | Outil de transfert et de production de proteines mettant en oeuvre le systeme de secretion de type iii de pseudomonas |
| WO2007044406A2 (en) | 2005-10-04 | 2007-04-19 | Ludwig Institute For Cancer Research | Methods for stimulating an immune response using bacterial antigen delivery system |
| WO2008019183A2 (en) | 2006-05-18 | 2008-02-14 | The Regents Of The University Of California | Biopolymer and protein production using type iii secretion systems of gram negative bacteria |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| JP5670875B2 (ja) | 2008-03-17 | 2015-02-18 | ウニベルジテーツクリニクム ミュンスター | カーゴ分子の送達ビヒクルおよび炎症反応を免疫調節するための生物学的治療剤としてのＹｏｐＭ |
| AU2015227479B2 (en) * | 2008-11-21 | 2017-05-04 | Københavns Universitet (University Of Copenhagen) | Priming of an immune response |
| AU2014225717B2 (en) * | 2013-03-07 | 2019-01-17 | President And Fellows Of Harvard College | Compositions and methods for bacterial delivery of polypeptides |
| CA2925417C (en) | 2013-09-24 | 2023-10-24 | Fahar Merchant | Interleukin-4 receptor-binding fusion proteins and uses thereof |
| US10143743B2 (en) | 2013-11-18 | 2018-12-04 | Yale University | Non-replicating bacterial nanoparticle delivery system and methods of use |
| EA201692025A1 (ru) | 2014-05-21 | 2017-05-31 | Университет Базель | Доставка белков, осуществляемая на основе бактерий |
| US11166987B2 (en) | 2015-11-19 | 2021-11-09 | Universitaet Basel | Virulence attenuated bacteria for treatment of malignant solid tumors |
| SI3377634T1 (sl) | 2015-11-19 | 2021-01-29 | Universitaet Basel | Dostava na bakterijah osnovanih proteinov |
| BR112019012338A2 (pt) | 2016-12-20 | 2019-11-26 | Univ Basel | liberação de proteína à base de bactérias de virulência atenuada |
-
2017
- 2017-12-20 BR BR112019012338A patent/BR112019012338A2/pt unknown
- 2017-12-20 CA CA3046852A patent/CA3046852A1/en active Pending
- 2017-12-20 MX MX2019007264A patent/MX2019007264A/es unknown
- 2017-12-20 SI SI201730906T patent/SI3559022T1/sl unknown
- 2017-12-20 DK DK17837961.6T patent/DK3559022T3/da active
- 2017-12-20 LT LTEPPCT/EP2017/083853T patent/LT3559022T/lt unknown
- 2017-12-20 ES ES17837961T patent/ES2886672T3/es active Active
- 2017-12-20 HU HUE17837961A patent/HUE055832T2/hu unknown
- 2017-12-20 JP JP2019554020A patent/JP6976351B2/ja active Active
- 2017-12-20 HR HRP20211516TT patent/HRP20211516T1/hr unknown
- 2017-12-20 EP EP21182133.5A patent/EP3957645A1/en active Pending
- 2017-12-20 WO PCT/EP2017/083853 patent/WO2018115140A2/en unknown
- 2017-12-20 EP EP17837961.6A patent/EP3559022B1/en active Active
- 2017-12-20 KR KR1020197020458A patent/KR102569949B1/ko active IP Right Grant
- 2017-12-20 EA EA201991157A patent/EA201991157A1/ru unknown
- 2017-12-20 MY MYPI2019003404A patent/MY192537A/en unknown
- 2017-12-20 AU AU2017384611A patent/AU2017384611B2/en active Active
- 2017-12-20 MA MA47119A patent/MA47119B1/fr unknown
- 2017-12-20 CN CN201780086910.8A patent/CN110325545B/zh active Active
- 2017-12-20 US US16/471,264 patent/US11518789B2/en active Active
- 2017-12-20 RS RS20211101A patent/RS62303B1/sr unknown
- 2017-12-20 NZ NZ754510A patent/NZ754510A/en unknown
- 2017-12-20 PE PE2019001289A patent/PE20191356A1/es unknown
- 2017-12-20 PT PT178379616T patent/PT3559022T/pt unknown
- 2017-12-20 PL PL17837961T patent/PL3559022T3/pl unknown
-
2019
- 2019-06-06 PH PH12019550092A patent/PH12019550092A1/en unknown
- 2019-06-13 IL IL267346A patent/IL267346A/en unknown
- 2019-06-19 CL CL2019001698A patent/CL2019001698A1/es unknown
- 2019-06-21 CO CONC2019/0006675A patent/CO2019006675A2/es unknown
-
2021
- 2021-08-31 CY CY20211100768T patent/CY1124488T1/el unknown
-
2022
- 2022-10-18 US US18/047,586 patent/US20230250138A1/en active Pending
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