HUE052269T2 - NRF2-t aktiváló vegyületek és alkalmazásuk - Google Patents
NRF2-t aktiváló vegyületek és alkalmazásukInfo
- Publication number
- HUE052269T2 HUE052269T2 HUE17705261A HUE17705261A HUE052269T2 HU E052269 T2 HUE052269 T2 HU E052269T2 HU E17705261 A HUE17705261 A HU E17705261A HU E17705261 A HUE17705261 A HU E17705261A HU E052269 T2 HUE052269 T2 HU E052269T2
- Authority
- HU
- Hungary
- Prior art keywords
- activating compounds
- nrf2 activating
- nrf2
- compounds
- activating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662290748P | 2016-02-03 | 2016-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE052269T2 true HUE052269T2 (hu) | 2021-04-28 |
Family
ID=58044203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17705261A HUE052269T2 (hu) | 2016-02-03 | 2017-02-02 | NRF2-t aktiváló vegyületek és alkalmazásuk |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9845307B2 (hu) |
| EP (1) | EP3411361B1 (hu) |
| JP (1) | JP7106453B2 (hu) |
| CN (2) | CN108699011B (hu) |
| CA (1) | CA3013080A1 (hu) |
| DK (1) | DK3411361T3 (hu) |
| ES (1) | ES2846886T3 (hu) |
| HU (1) | HUE052269T2 (hu) |
| PT (1) | PT3411361T (hu) |
| WO (1) | WO2017136589A1 (hu) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7202184B2 (ja) | 2016-02-03 | 2023-01-11 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｎｒｆ２活性化化合物およびその使用 |
| JP2021523197A (ja) * | 2018-05-16 | 2021-09-02 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｎｒｆ２活性化化合物のプロドラッグおよびその使用 |
| WO2021002473A1 (ja) * | 2019-07-03 | 2021-01-07 | 千寿製薬株式会社 | Ｎｒｆ２活性化化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW424087B (en) * | 1995-04-06 | 2001-03-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives |
| DE19823131A1 (de) * | 1998-05-23 | 1999-11-25 | Bayer Ag | Sulfonylamino(thio)carbonyltriazolin(thi)one mit Alkenyl-Substituenten |
| US8101373B2 (en) | 2007-10-12 | 2012-01-24 | Discoverx Corporation | β-galactosidase donor fragments |
| WO2011109799A1 (en) * | 2010-03-05 | 2011-09-09 | Karyopharm Therapeutics, Inc. | Nuclear transport modulatiors and uses thereof |
| US8795904B2 (en) | 2010-05-13 | 2014-08-05 | The United States Of America As Represented By The Secretary Of The Army | Nonaqueous electrolyte solvents and additives |
| KR101438655B1 (ko) * | 2012-04-30 | 2014-09-17 | 한국과학기술연구원 | 산화질소 생성 억제 효과와 Ｎｒｆ2 활성 효과를 통해 뇌신경 질환 예방 및 치료용으로 사용 가능한 활성화된 비닐기를 포함하는 벤질 유도체 화합물 및 이의 약학조성물 |
| EP2934503B1 (en) | 2012-12-21 | 2019-04-10 | Biogen MA Inc. | Deuterium substituted fumarate derivatives |
| EP3083614B1 (en) | 2013-12-18 | 2020-01-15 | GlaxoSmithKline Intellectual Property Development Limited | Nrf2 regulators |
| EP3177599B1 (en) | 2014-08-04 | 2019-12-04 | Rigel Pharmaceuticals, Inc. | Fumarate analogs and uses thereof in the treatment of an autoimmune disease or an inflammatory disease |
| JP7202184B2 (ja) | 2016-02-03 | 2023-01-11 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｎｒｆ２活性化化合物およびその使用 |
-
2017
- 2017-02-02 CN CN201780011416.5A patent/CN108699011B/zh not_active Expired - Fee Related
- 2017-02-02 US US15/423,436 patent/US9845307B2/en active Active
- 2017-02-02 HU HUE17705261A patent/HUE052269T2/hu unknown
- 2017-02-02 WO PCT/US2017/016276 patent/WO2017136589A1/en active Application Filing
- 2017-02-02 DK DK17705261.0T patent/DK3411361T3/da active
- 2017-02-02 PT PT177052610T patent/PT3411361T/pt unknown
- 2017-02-02 EP EP17705261.0A patent/EP3411361B1/en active Active
- 2017-02-02 ES ES17705261T patent/ES2846886T3/es active Active
- 2017-02-02 CA CA3013080A patent/CA3013080A1/en active Pending
- 2017-02-02 JP JP2018539931A patent/JP7106453B2/ja active Active
- 2017-02-02 CN CN202210433952.7A patent/CN114617868A/zh active Pending
- 2017-11-13 US US15/811,088 patent/US10556881B2/en active Active
-
2019
- 2019-12-20 US US16/723,881 patent/US10844040B2/en active Active
-
2020
- 2020-10-20 US US17/075,152 patent/US11279686B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2846886T3 (es) | 2021-07-30 |
| US10556881B2 (en) | 2020-02-11 |
| CN114617868A (zh) | 2022-06-14 |
| CN108699011B (zh) | 2022-05-06 |
| DK3411361T3 (da) | 2021-02-01 |
| US20210078969A1 (en) | 2021-03-18 |
| US10844040B2 (en) | 2020-11-24 |
| WO2017136589A1 (en) | 2017-08-10 |
| PT3411361T (pt) | 2021-01-29 |
| US11279686B2 (en) | 2022-03-22 |
| US9845307B2 (en) | 2017-12-19 |
| CA3013080A1 (en) | 2017-08-10 |
| EP3411361B1 (en) | 2020-11-25 |
| US20180258063A1 (en) | 2018-09-13 |
| US20200216412A1 (en) | 2020-07-09 |
| JP2019504084A (ja) | 2019-02-14 |
| US20170217922A1 (en) | 2017-08-03 |
| CN108699011A (zh) | 2018-10-23 |
| JP7106453B2 (ja) | 2022-07-26 |
| EP3411361A1 (en) | 2018-12-12 |
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