HUE046089T2 - Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához - Google Patents
Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításáhozInfo
- Publication number
- HUE046089T2 HUE046089T2 HUE12795954A HUE12795954A HUE046089T2 HU E046089 T2 HUE046089 T2 HU E046089T2 HU E12795954 A HUE12795954 A HU E12795954A HU E12795954 A HUE12795954 A HU E12795954A HU E046089 T2 HUE046089 T2 HU E046089T2
- Authority
- HU
- Hungary
- Prior art keywords
- biocatalysts
- hydroxy
- preparation
- substituted carbamates
- carbamates
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 239000011942 biocatalyst Substances 0.000 title 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161561665P | 2011-11-18 | 2011-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE046089T2 true HUE046089T2 (hu) | 2020-01-28 |
Family
ID=47295185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE12795954A HUE046089T2 (hu) | 2011-11-18 | 2012-11-14 | Biokatalizátorok hidroxi-szubsztituált karbamátok elõállításához |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US9139819B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2780448B1 (cg-RX-API-DMAC10.html) |
| CN (2) | CN104053771B (cg-RX-API-DMAC10.html) |
| HU (1) | HUE046089T2 (cg-RX-API-DMAC10.html) |
| IL (1) | IL232621B (cg-RX-API-DMAC10.html) |
| IN (1) | IN2014CN04470A (cg-RX-API-DMAC10.html) |
| SG (1) | SG11201402401TA (cg-RX-API-DMAC10.html) |
| WO (1) | WO2013074650A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7977078B2 (en) | 2007-08-24 | 2011-07-12 | Codexis, Inc. | Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane |
| ES2584427T3 (es) | 2011-10-27 | 2016-09-27 | Merck Sharp & Dohme Corp. | Proceso para la preparación de agonistas beta 3 y productos intermedios |
| US20150087832A1 (en) | 2011-10-27 | 2015-03-26 | Merck Sharp & Dohme, Corp. | Process for making beta 3 agonists and intermediates |
| IN2014CN04470A (cg-RX-API-DMAC10.html) * | 2011-11-18 | 2015-09-04 | Codexis Inc | |
| DK2968269T3 (da) | 2013-03-15 | 2019-10-07 | Merck Sharp & Dohme | Fremgangsmåde til fremstilling af beta-3-agonister og mellemprodukter |
| US10150959B2 (en) * | 2013-03-15 | 2018-12-11 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| ES2830725T3 (es) * | 2015-02-10 | 2021-06-04 | Codexis Inc | Polipéptidos cetoreductasa para la síntesis de compuestos quirales |
| CN106011095B (zh) * | 2016-07-27 | 2021-02-26 | 苏州汉酶生物技术有限公司 | 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法 |
| CN110869022A (zh) | 2017-06-06 | 2020-03-06 | 乌洛万特科学有限公司 | 使用维贝隆以治疗膀胱过度活动症 |
| AU2019393372B2 (en) | 2018-12-05 | 2025-08-21 | Sumitomo Pharma Co., Ltd | Vibegron for the treatment of overactive bladder symptoms |
| CN109943543B (zh) * | 2019-03-28 | 2020-12-11 | 上海健康医学院 | 醇脱氢酶突变体及其制备方法和应用 |
| CN114410599B (zh) * | 2022-01-29 | 2023-08-18 | 浙江工业大学 | 羰基还原酶突变体及其制备瑞舒伐他汀手性中间体的应用 |
| CN116814569B (zh) * | 2023-05-30 | 2025-07-25 | 华东理工大学 | 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用 |
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| US5538867A (en) | 1988-09-13 | 1996-07-23 | Elf Aquitaine | Process for the electrochemical regeneration of pyridine cofactors |
| JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法 |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| US5891685A (en) | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| CA2298572C (en) | 1997-10-08 | 2002-04-09 | Isotechnika Inc. | Deuterated cyclosporine analogs and their use as immunomodulating agents |
| EP1036198B1 (en) | 1997-12-08 | 2012-09-26 | California Institute Of Technology | Method for creating polynucleotide and polypeptide sequences |
| US6495023B1 (en) | 1998-07-09 | 2002-12-17 | Michigan State University | Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration |
| DE19857302C2 (de) | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
| JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| EP1621613B1 (en) | 1999-03-11 | 2009-04-22 | Eastman Chemical Company | Enzymatic reductions with dihydrogen via metal catalyzed cofactor regeneration |
| CZ20012792A3 (cs) | 1999-12-03 | 2002-03-13 | Kaneka Corporation | Polypeptid, polynukleotid kódující polypeptid, expresní vektor, transformant a způsob přípravy |
| WO2001075767A2 (en) | 2000-03-30 | 2001-10-11 | Maxygen, Inc. | In silico cross-over site selection |
| EP1370677A1 (en) | 2001-03-22 | 2003-12-17 | Bristol-Myers Squibb Company | Stereoselective reduction of substituted acetophenone |
| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| US7824898B2 (en) | 2003-08-11 | 2010-11-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7816111B2 (en) | 2003-08-11 | 2010-10-19 | Codexis, Inc. | Glucose dehydrogenase polypeptides and related polynucleotides |
| KR20060071397A (ko) | 2003-08-11 | 2006-06-26 | 코덱시스, 인코포레이티드 | 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법 |
| WO2005017135A1 (en) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| US20080050787A1 (en) | 2003-12-02 | 2008-02-28 | Hazuki Nagai | Method for Manufacturing Optically Active Tetrahydrothiophene Derivative and Method for Crystallization of Optically Active Tetrahydrothiophene-3-Ol |
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| WO2006130657A2 (en) | 2005-05-31 | 2006-12-07 | Bristol-Myers Squibb Company | Stereoselective reduction process for the preparation of pyrrolotriazine compounds |
| US7820421B2 (en) * | 2007-02-08 | 2010-10-26 | Codexis, Inc. | Ketoreductases and uses thereof |
| US20090118130A1 (en) | 2007-02-12 | 2009-05-07 | Codexis, Inc. | Structure-activity relationships |
| US7977078B2 (en) * | 2007-08-24 | 2011-07-12 | Codexis, Inc. | Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane |
| KR101586503B1 (ko) | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
| WO2009042984A1 (en) | 2007-09-28 | 2009-04-02 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| EP2205727B1 (en) | 2007-10-01 | 2015-06-24 | Codexis, Inc. | Ketoreductase polypeptides for the production of azetidinone |
| PE20091825A1 (es) | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| WO2010027710A2 (en) | 2008-08-27 | 2010-03-11 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| SI2329013T1 (sl) * | 2008-08-27 | 2016-03-31 | Codexis, Inc. | Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina |
| EP2329014B1 (en) | 2008-08-29 | 2014-10-22 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| SG10201405022PA (en) | 2009-08-19 | 2014-10-30 | Codexis Inc | Ketoreductase polypeptides for the preparation of phenylephrine |
| WO2011140219A1 (en) | 2010-05-04 | 2011-11-10 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| IN2014CN04470A (cg-RX-API-DMAC10.html) | 2011-11-18 | 2015-09-04 | Codexis Inc |
-
2012
- 2012-11-14 IN IN4470CHN2014 patent/IN2014CN04470A/en unknown
- 2012-11-14 CN CN201280067329.9A patent/CN104053771B/zh active Active
- 2012-11-14 CN CN201610911937.3A patent/CN106479990B/zh active Active
- 2012-11-14 SG SG11201402401TA patent/SG11201402401TA/en unknown
- 2012-11-14 WO PCT/US2012/065046 patent/WO2013074650A1/en not_active Ceased
- 2012-11-14 US US14/357,964 patent/US9139819B2/en active Active
- 2012-11-14 EP EP12795954.2A patent/EP2780448B1/en active Active
- 2012-11-14 HU HUE12795954A patent/HUE046089T2/hu unknown
-
2014
- 2014-05-14 IL IL23262114A patent/IL232621B/en active IP Right Grant
-
2015
- 2015-08-13 US US14/825,688 patent/US9422531B2/en active Active
-
2016
- 2016-07-15 US US15/211,990 patent/US9803178B2/en active Active
-
2017
- 2017-09-21 US US15/711,119 patent/US10100287B2/en active Active
-
2018
- 2018-09-10 US US16/126,044 patent/US10253303B2/en active Active
-
2019
- 2019-02-25 US US16/284,235 patent/US10851351B2/en active Active
-
2020
- 2020-10-29 US US17/084,405 patent/US11713451B2/en active Active
-
2023
- 2023-06-12 US US18/333,393 patent/US12241093B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10851351B2 (en) | 2020-12-01 |
| US20150344850A1 (en) | 2015-12-03 |
| CN106479990B (zh) | 2020-09-18 |
| US9139819B2 (en) | 2015-09-22 |
| CN106479990A (zh) | 2017-03-08 |
| IL232621B (en) | 2019-10-31 |
| IN2014CN04470A (cg-RX-API-DMAC10.html) | 2015-09-04 |
| SG11201402401TA (en) | 2014-06-27 |
| EP2780448B1 (en) | 2019-09-11 |
| US9422531B2 (en) | 2016-08-23 |
| CN104053771A (zh) | 2014-09-17 |
| US10253303B2 (en) | 2019-04-09 |
| US20140322769A1 (en) | 2014-10-30 |
| IL232621A0 (en) | 2014-06-30 |
| US20240018489A1 (en) | 2024-01-18 |
| US20190177702A1 (en) | 2019-06-13 |
| US20180371427A1 (en) | 2018-12-27 |
| US20210071151A1 (en) | 2021-03-11 |
| US20180010100A1 (en) | 2018-01-11 |
| US9803178B2 (en) | 2017-10-31 |
| CN104053771B (zh) | 2016-11-09 |
| US12241093B2 (en) | 2025-03-04 |
| EP2780448A1 (en) | 2014-09-24 |
| US11713451B2 (en) | 2023-08-01 |
| WO2013074650A1 (en) | 2013-05-23 |
| US20160319247A1 (en) | 2016-11-03 |
| US10100287B2 (en) | 2018-10-16 |
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