HUE037976T2 - A Rozuvasztatin-kalcium elõállítására szolgáló intermedier vegyület és az elõállítás módszer - Google Patents
A Rozuvasztatin-kalcium elõállítására szolgáló intermedier vegyület és az elõállítás módszerInfo
- Publication number
- HUE037976T2 HUE037976T2 HUE14885058A HUE14885058A HUE037976T2 HU E037976 T2 HUE037976 T2 HU E037976T2 HU E14885058 A HUE14885058 A HU E14885058A HU E14885058 A HUE14885058 A HU E14885058A HU E037976 T2 HUE037976 T2 HU E037976T2
- Authority
- HU
- Hungary
- Prior art keywords
- rosuvastatin calcium
- preparing rosuvastatin
- intermediate compound
- therefrom
- preparing
- Prior art date
Links
- 229960004796 rosuvastatin calcium Drugs 0.000 title 2
- LALFOYNTGMUKGG-BGRFNVSISA-L rosuvastatin calcium Chemical compound [Ca+2].CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O.CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O LALFOYNTGMUKGG-BGRFNVSISA-L 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14885058.9A EP3115367B1 (fr) | 2014-03-07 | 2014-03-07 | Composé intermédiaire pour la préparation de rosuvastatine calcique et procédé de préparation de rosuvastatine calcique à partir de celui-ci |
| PCT/CN2014/073079 WO2015131405A1 (fr) | 2014-03-07 | 2014-03-07 | Composé intermédiaire pour la préparation de rosuvastatine calcique et procédé de préparation de rosuvastatine calcique à partir de celui-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE037976T2 true HUE037976T2 (hu) | 2018-09-28 |
Family
ID=54054408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14885058A HUE037976T2 (hu) | 2014-03-07 | 2014-03-07 | A Rozuvasztatin-kalcium elõállítására szolgáló intermedier vegyület és az elõállítás módszer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9926283B2 (fr) |
| EP (1) | EP3115367B1 (fr) |
| JP (1) | JP6240346B2 (fr) |
| ES (1) | ES2655062T3 (fr) |
| HU (1) | HUE037976T2 (fr) |
| PT (1) | PT3115367T (fr) |
| WO (1) | WO2015131405A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106674281B (zh) * | 2016-12-31 | 2019-05-07 | 安徽美诺华药物化学有限公司 | 一种瑞舒伐他汀中间体化合物、制备方法及其用途 |
| WO2019008593A1 (fr) * | 2017-07-05 | 2019-01-10 | Melody Healthcare Pvt. Ltd | Procédé pour la fabrication de rosuvastatine calcique amorphe |
| CN111548312A (zh) * | 2020-06-01 | 2020-08-18 | 雅本化学股份有限公司 | 一种瑞舒伐他汀钙片及其制备工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| GB9903472D0 (en) | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
| WO2004103977A2 (fr) * | 2003-05-21 | 2004-12-02 | Ciba Specialty Chemicals Holding Inc. | Procede de preparation de derives de pyrimidine |
| WO2005054207A1 (fr) * | 2003-12-04 | 2005-06-16 | Glenmark Pharmaceuticals Limited | Procede de preparation de derives de pyrimidine |
| CN102351901A (zh) | 2011-08-15 | 2012-02-15 | 上海皓元化学科技有限公司 | 25-羟基维生素d2系列药物侧链及其制备方法 |
| CN102643302A (zh) | 2012-04-06 | 2012-08-22 | 上海皓元化学科技有限公司 | 25-羟基维生素D2和1α,25-二羟基维生素D2合成中间体的制备方法 |
| CN103804414B (zh) * | 2014-03-07 | 2016-04-13 | 凯莱英医药集团（天津）股份有限公司 | 用于制备瑞舒伐他汀钙的中间体化合物以及由其制备瑞舒伐他汀钙的方法 |
-
2014
- 2014-03-07 JP JP2016572868A patent/JP6240346B2/ja not_active Expired - Fee Related
- 2014-03-07 WO PCT/CN2014/073079 patent/WO2015131405A1/fr active Application Filing
- 2014-03-07 EP EP14885058.9A patent/EP3115367B1/fr not_active Not-in-force
- 2014-03-07 HU HUE14885058A patent/HUE037976T2/hu unknown
- 2014-03-07 US US15/124,083 patent/US9926283B2/en not_active Expired - Fee Related
- 2014-03-07 PT PT148850589T patent/PT3115367T/pt unknown
- 2014-03-07 ES ES14885058.9T patent/ES2655062T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017508790A (ja) | 2017-03-30 |
| EP3115367B1 (fr) | 2017-11-01 |
| US20170022169A1 (en) | 2017-01-26 |
| JP6240346B2 (ja) | 2017-11-29 |
| US9926283B2 (en) | 2018-03-27 |
| WO2015131405A1 (fr) | 2015-09-11 |
| EP3115367A1 (fr) | 2017-01-11 |
| ES2655062T3 (es) | 2018-02-16 |
| PT3115367T (pt) | 2018-01-04 |
| EP3115367A4 (fr) | 2017-01-11 |
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