HUE034684T2 - Gyógyszeradagoló rendszer vízben rosszul oldódó gyógyászati hatóanyagok adagolására - Google Patents
Gyógyszeradagoló rendszer vízben rosszul oldódó gyógyászati hatóanyagok adagolására Download PDFInfo
- Publication number
- HUE034684T2 HUE034684T2 HUE08861526A HUE08861526A HUE034684T2 HU E034684 T2 HUE034684 T2 HU E034684T2 HU E08861526 A HUE08861526 A HU E08861526A HU E08861526 A HUE08861526 A HU E08861526A HU E034684 T2 HUE034684 T2 HU E034684T2
- Authority
- HU
- Hungary
- Prior art keywords
- methyl ester
- sodium salt
- cysteic acid
- trans
- retinoyl cysteic
- Prior art date
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- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
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- Transplantation (AREA)
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Claims (4)
- ;$yög:P&ertdaQ©jó rendszér vízben rmmitéMMé gyógyászati hatáabyágökradá* gölásáca: Szabadalmi igénypontok % oyogyszetadagölő randazer legalább agy gyögyászailag aktiy aapi adaioiá-' sára, melynékper se vízofd hatósága kisébbf mint 100 mg/mt :ll~^:C":fiífcérsék“ íetéfV ahol: az: anyag li|allbfe#0%r:lÉrt ssÉmcsés formájú és €13: nm hullám-· hosszú vörös lézerrel végzett dinamikus fény pásztázási módszerrel mért Z· átlagos átmérője kisebb,, mint 50 nm, azzal jellemezve* hogy » m anyagrészecskék nem -kristályosak vagy ÍD nm vagy kisebb részecskeméretű kristály okból állnak; - áz ányagriszeeskék i-allfcrahs-retinöli dszteinsav melliészter nitrlypísií dsz-retinöll dszteinsav metifészter oáttlumsó, vagy azok kombinációja által képzeté ha hörészecskÉkhe foglalta k; és ~ az b-alirans^rabbdil dezteinsay metilészter nátriumsó, Ν-13-dsz-retiooil dszteinsav meti!#sztar :nltnumsáf vagy azok lombínádója és az anyag tömeg" aránya:0,5:1 is 20rí közötti,:
- 2, Az 1, Igénypont szerinti gyógyszeradagoló rendszer azzal jellemezve, hogy az b-aliridi-ritihoii clsztelnsáv metílészter nátriumáé* N-dS-disz-retinöli elsztéinsav meblisztor natrlymsöí vagy azok kombinációja és az anyag tömegaránya 1:1 és :0:i közötti,
- 3, Az előző igénypontok bármelyike szerinti: gyógyszeradagoló rendszer azzal jellemezve,, hogy az anyag egy dtofoxdus vagy egy cltOletatlkus vegyület. 4, A 3, ígénypontrazerlnti gyögyszeradagolö rendszer azzal jellemezve, hogy a citotOxikus vagy ciösztatlkus vegyület egy lazán, 5, A 4, igénypont szerinti gyógyszeradagoló rendszer azzal jellemezve, hogy a taxán paclltaxeó és clocetaxel közül választott:, 0, $ igénypontok bármelyike szerinti gyógyszeradagoló; rendszer rák kméW* 'Sitién történő a (káliba zásré,: .7; Az :Ά igénypontok bármelyiké iééiláö gyogpiiradagolő répőMör aEipl jii-léméivé, hogy az anyag egy immunszupresszánS:, ;0, a 7; |||nypónt szerinti gyógyszeradagofö rendszer azzal jellemezve, hogy az immunszopresszlos dklosponn, skoíirops, és téorőíimus közül választott, ·#, A 7-#« igénypontok bármelyike szerinti pbstailogén izarvátoitatélbén történő alkaipazásri:, l|, Gyógyászati készítmény, mely egy gyógyászati lég elfogadható ihordozót is az ti”!, 7, és i < igénypontok bármelyike szerinti gyógyszeradagoló teniszért tartok mázzá. 11, 'N''aiití«ns-retifioi1 clsátéíniay metilészter nátrium só, N-lI-dsz-mlnoíl elsztélnsav mád iészter nátriumáé,- vagy azok komÖináaöjÉnak alkaimazása az 1-5, 7. ás i, Igénypontok bármelyiké szerinti gyógyszeráöigbiö rendszer előállításában,·
- 12, A j~f; igénypontok bármelyike szerlnttgyégyszerada§©io rendszer alkalma-zása rák keiéíisire szolgáló gyógyszer előállítására. 13, A 3~S. Igénypontok bármelyiké szerinti gyógyszeradagoló rendszer alkalma-zása postaliogén szervátültetésben alkalmazott gyógyszer előállítására
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SE2007/001127 WO2009078754A1 (en) | 2007-12-19 | 2007-12-19 | Drug delivery system for administration of poorly water soluble pharmaceutically active substances |
Publications (1)
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| HUE034684T2 true HUE034684T2 (hu) | 2018-02-28 |
Family
ID=40795732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE08861526A HUE034684T2 (hu) | 2007-12-19 | 2008-12-18 | Gyógyszeradagoló rendszer vízben rosszul oldódó gyógyászati hatóanyagok adagolására |
Country Status (27)
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| EP (1) | EP2231189B1 (hu) |
| JP (1) | JP5466172B2 (hu) |
| KR (1) | KR101572703B1 (hu) |
| CN (1) | CN101951956B (hu) |
| AU (1) | AU2008339099B2 (hu) |
| BR (1) | BRPI0821740B1 (hu) |
| CA (1) | CA2709266C (hu) |
| CY (2) | CY1119805T1 (hu) |
| DK (1) | DK2231189T3 (hu) |
| EA (1) | EA015247B1 (hu) |
| ES (1) | ES2650242T3 (hu) |
| FR (1) | FR19C1030I1 (hu) |
| HR (1) | HRP20171796T1 (hu) |
| HU (1) | HUE034684T2 (hu) |
| LT (2) | LT2231189T (hu) |
| LU (1) | LUC00117I2 (hu) |
| MX (1) | MX2010006914A (hu) |
| MY (2) | MY157186A (hu) |
| NL (1) | NL300987I9 (hu) |
| NO (2) | NO2231189T3 (hu) |
| NZ (1) | NZ586859A (hu) |
| PL (1) | PL2231189T3 (hu) |
| PT (1) | PT2231189T (hu) |
| SI (1) | SI2231189T1 (hu) |
| WO (2) | WO2009078754A1 (hu) |
| ZA (1) | ZA201004685B (hu) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009078756A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| WO2009078754A1 (en) * | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of poorly water soluble pharmaceutically active substances |
| WO2009078755A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| CA2759332A1 (en) * | 2009-04-21 | 2010-10-28 | Selecta Biosciences, Inc. | Immunonanotherapeutics providing a th1-biased response |
| CN106177940A (zh) | 2010-05-26 | 2016-12-07 | 西莱克塔生物科技公司 | 含有佐剂的合成纳米载体的剂量选择 |
| US9994443B2 (en) | 2010-11-05 | 2018-06-12 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| CN103908432B (zh) * | 2013-01-02 | 2018-09-21 | 博瑞生物医药（苏州）股份有限公司 | 一种伊沙匹隆白蛋白的冻干组合物及其制备方法 |
| CN112239418B (zh) * | 2019-07-18 | 2023-07-07 | 上海现代药物制剂工程研究中心有限公司 | 视黄醇类化合物及其钠盐的制备方法 |
| CN112321465B (zh) * | 2019-07-18 | 2023-06-06 | 上海现代药物制剂工程研究中心有限公司 | 一种含苯基化合物、其中间体、制备方法及应用 |
| WO2021259472A1 (en) * | 2020-06-24 | 2021-12-30 | Oasmia Pharmaceutical Ab | Micellar docetaxel for use in the treatment of cancer |
| CN115429886B (zh) * | 2021-06-02 | 2025-10-31 | 复旦大学 | 一种药物纳米结晶制剂及其制备方法 |
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| US6096331A (en) * | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| DE19839566C2 (de) * | 1998-08-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten in der Transplantationsmedizin |
| US6197809B1 (en) * | 1998-12-23 | 2001-03-06 | Ardenia Investments Ltd. | Compounds for the treatment of cancer |
| US6656504B1 (en) * | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
| SE0101702D0 (sv) * | 2001-05-15 | 2001-05-15 | Ardenia Investments Ltd | Novel potentiating compounds |
| US20050249786A1 (en) * | 2001-09-28 | 2005-11-10 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds |
| US20050191359A1 (en) * | 2001-09-28 | 2005-09-01 | Solubest Ltd. | Water soluble nanoparticles and method for their production |
| SE0202311D0 (sv) * | 2002-07-23 | 2002-07-23 | Ardenia Investments Ltd | Novel compounds, cytotoxic preparations comprising said compounds, methods of manufacture of said preparations, as well as methods of treatment |
| CN100360502C (zh) * | 2002-07-23 | 2008-01-09 | 阿登尼亚投资有限公司 | 视黄醇衍生物、它们在治疗癌症和增强其它细胞毒性剂功效中的应用 |
| US7259984B2 (en) * | 2002-11-26 | 2007-08-21 | Cornell Research Foundation, Inc. | Multibit metal nanocrystal memories and fabrication |
| JP2006199590A (ja) | 2003-09-04 | 2006-08-03 | Nano Career Kk | 水溶性の塩基性薬物内包ナノ粒子含有組成物 |
| US20050196343A1 (en) | 2004-02-27 | 2005-09-08 | Molecular Therapeutics, Inc. | Degradable nanoparticles |
| US7871632B2 (en) | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| US8945629B2 (en) * | 2004-09-10 | 2015-02-03 | University Of Wyoming | Nanoparticles for cytoplasmic drug delivery to cancer cells |
| AU2006284657B2 (en) * | 2005-08-31 | 2012-07-19 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
| WO2009078756A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| WO2009078754A1 (en) * | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of poorly water soluble pharmaceutically active substances |
| WO2009078755A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
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