HUE026406T2 - Sclerosis multiplex kezelése laquinimoddal - Google Patents
Sclerosis multiplex kezelése laquinimoddal Download PDFInfo
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- HUE026406T2 HUE026406T2 HUE10789873A HUE10789873A HUE026406T2 HU E026406 T2 HUE026406 T2 HU E026406T2 HU E10789873 A HUE10789873 A HU E10789873A HU E10789873 A HUE10789873 A HU E10789873A HU E026406 T2 HUE026406 T2 HU E026406T2
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- laquinimod
- study
- multiple sclerosis
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
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Claims (9)
- Sderosis multiplex kezelése iaquinímoddai Szabadalmi igénypontok 1 Laguinimod a visszaesés mértékének csökkentésére ée/vagy fizikai gyengeség fokozódá sának csökkentésére javuló-rosszabbodé sclerosis multiplexben szenvedő betegben a bizonyítottan előrehaladott betegség idején megállapított fizikai fogyatékosság fokozódásának csökkenésére, ahol a laquinomod népi 0.6 mg Papi dőzístartoroányban förténő adagolásra van kialakítva. £L Laguinimod az 1. igénypont szerinti alkalmazásra, ahol a megerősített betegség-előrehaladás idejét Kurizke Expanded Disability Status Scale {EDSS} módszerrel mérjük.
- 3. Laguinimod az 1. vagy 2 igénypont szerinti alkalmazásra 0-5.6 EDSS értékkel rendelkező betegben a fizikai fogyatékosság felhalmozódásának csökkentésére.
- 4. Laguinimod az 1, vagy 2, igénypont szerint! alkalmazásra 5.5 vagy magasabb EDSS ér-
- 5. Laguinimod a 3. igénypont szerint! alkalmazásra, ahol a megerősített betegség-előrehaladás ez EDSS érték 1 pontos növekedése,
- 6. Laquinimod a igénypont szerint! alkalmazásra, ahol á megerősített betegség^ előrehaladás az EDSS érték 0,5 pontos növekedése,
- 7. Laguinimod a 2-6, igénypontok bármelyike szerinti alkalmazásra, aboi a megerősített be-tegség-eiörehaiadás növekedése 20-60%
- 8. Laguinimod az 1-7. igénypontok bármelyike szerinti alkalmazásra, ahol a íaqplnimed laguinimod nátrium fomájában áll. 9. taquinimod az 1-6. igénypontok bármelyike szerinti alkalmazásra, mint monoterápia a javuíd-rosszabbodé sclerosis multiplex kezelésére. 10, taquimniad ág 1 -S igénypontok bármelyike szerinti alkalmazásra, mint járulékos terápia egy másik jávOlő-rosszabbodé sclerosis multiplex kezelés mellett. 11. taquinlmod a 10. Igénypont szenei alkalmazásra, ahol a másik javulő-rosszabbodo sclerosis multiplex kezelés interferon beta i-s, interferon beta 1~b, glatiramer aeeíát, mttoxantrone vagy natáilzuáiab adagolása t'2. Laqaínimod ez 1-t1, igénypontok bármelyike szerinti alkalmazásra, ahol a lestuinsnod 24 hétnél hosszabb időtartamba?! történő napi alkalmazásra kialakított.
- 13. PagylntmaP a 10. igénypont szerinti alkalmazásra, ahol a íaquinimoci 24 hónapos, vagy annál hosszabb időtartamban történő napi alkalmazásra kialakított.
- 14. Laquinimod az 1-11. Igénypontok bármelyike szerinti alkalmazásra, ahol a iaquinimod 0.6 mg lapainimtÄtaPalmazo gyógyászati orális egpégdőzisra kialakított.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26907009P | 2009-06-19 | 2009-06-19 |
Publications (1)
| Publication Number | Publication Date |
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| HUE026406T2 true HUE026406T2 (hu) | 2016-06-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| HUE10789873A HUE026406T2 (hu) | 2009-06-19 | 2010-06-18 | Sclerosis multiplex kezelése laquinimoddal |
Country Status (26)
| Country | Link |
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| US (7) | US20100322900A1 (hu) |
| EP (2) | EP3028572A1 (hu) |
| JP (4) | JP2012530701A (hu) |
| KR (2) | KR20120037477A (hu) |
| CN (2) | CN102802415A (hu) |
| AU (2) | AU2010260455A1 (hu) |
| BR (1) | BR112012000568A2 (hu) |
| CY (1) | CY1116727T1 (hu) |
| DK (1) | DK2442651T3 (hu) |
| EA (1) | EA201270041A1 (hu) |
| ES (1) | ES2548999T3 (hu) |
| HK (1) | HK1169563A1 (hu) |
| HR (1) | HRP20150988T1 (hu) |
| HU (1) | HUE026406T2 (hu) |
| IL (2) | IL216780A0 (hu) |
| ME (1) | ME02282B (hu) |
| MX (1) | MX2011013902A (hu) |
| NZ (1) | NZ597378A (hu) |
| PL (1) | PL2442651T3 (hu) |
| PT (1) | PT2442651E (hu) |
| RS (1) | RS54328B1 (hu) |
| SG (2) | SG10201403397TA (hu) |
| SI (1) | SI2442651T1 (hu) |
| SM (1) | SMT201500262B (hu) |
| WO (1) | WO2010147665A1 (hu) |
| ZA (1) | ZA201200029B (hu) |
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| JP2843209B2 (ja) * | 1992-07-28 | 1999-01-06 | 株式会社クボタ | 苗詰め装置 |
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| ES2377149T3 (es) | 2006-06-12 | 2012-03-22 | Teva Pharmaceutical Industries Limited | Preparaciones de laquinimod estables |
| EP2977049A1 (en) | 2007-12-20 | 2016-01-27 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
| CN104311486A (zh) * | 2008-09-03 | 2015-01-28 | 泰华制药工业有限公司 | 2-羰基-1,2-二氢喹啉免疫功能调节剂 |
| SI2467372T1 (sl) | 2009-08-10 | 2016-09-30 | Teva Pharmaceutical Industries Ltd. | Zdravljenje motenj, povezanih z BDNF, z uporabo lakvinimoda |
| CN102781239B (zh) * | 2010-03-03 | 2015-01-21 | 泰华制药工业有限公司 | 使用拉喹莫德治疗狼疮关节炎 |
| KR20160129093A (ko) * | 2010-03-03 | 2016-11-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
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| JP2013535437A (ja) | 2010-07-09 | 2013-09-12 | テバ ファーマシューティカル インダストリーズ リミティド | 重水素化されたｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４−ヒドロキシ−５−クロロ−１−メチル−２−オキソキノリン−３−カルボキサミド、その塩および使用 |
| EA201390827A1 (ru) * | 2010-12-07 | 2013-12-30 | Тева Фармасьютикал Индастриз Лтд. | Применение лаквинимода для уменьшения утомляемости, улучшения функционального состояния и улучшения качества жизни пациентов с рассеянным склерозом |
| IN2014MN00333A (hu) * | 2011-07-28 | 2015-09-25 | Teva Pharma | |
| JP2014521659A (ja) * | 2011-07-28 | 2014-08-28 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドおよびインターフェロンβを組み合わせた多発性硬化症の治療 |
| WO2013055907A1 (en) * | 2011-10-12 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with combination of laquinimod and fingolimod |
| BR112014018485A8 (pt) | 2012-02-03 | 2017-07-11 | Teva Pharma | Uso de laquinimod para tratar pacientes com a doença de crohn que falharam com a primeira linha de terapia anti-tnf |
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| US20130259856A1 (en) * | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| TW201347762A (zh) * | 2012-05-02 | 2013-12-01 | Teva Pharma | 高劑量拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）於治療多發性硬化症之用途 |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
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| UY34896A (es) * | 2012-07-12 | 2014-02-28 | Teva Pharma | Tratamiento de la esclerosis múltiple con una combinación de laquinimod y fampridina |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
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2010
- 2010-06-18 RS RS20150645A patent/RS54328B1/en unknown
- 2010-06-18 ME MEP-2015-169A patent/ME02282B/me unknown
- 2010-06-18 EA EA201270041A patent/EA201270041A1/ru unknown
- 2010-06-18 EP EP15178731.4A patent/EP3028572A1/en not_active Withdrawn
- 2010-06-18 WO PCT/US2010/001759 patent/WO2010147665A1/en active Application Filing
- 2010-06-18 SG SG10201403397TA patent/SG10201403397TA/en unknown
- 2010-06-18 US US12/803,121 patent/US20100322900A1/en not_active Abandoned
- 2010-06-18 CN CN2010800272294A patent/CN102802415A/zh active Pending
- 2010-06-18 PT PT107898736T patent/PT2442651E/pt unknown
- 2010-06-18 EP EP10789873.6A patent/EP2442651B1/en active Active
- 2010-06-18 MX MX2011013902A patent/MX2011013902A/es active IP Right Grant
- 2010-06-18 PL PL10789873T patent/PL2442651T3/pl unknown
- 2010-06-18 BR BR112012000568A patent/BR112012000568A2/pt not_active IP Right Cessation
- 2010-06-18 NZ NZ597378A patent/NZ597378A/en not_active IP Right Cessation
- 2010-06-18 SI SI201031018T patent/SI2442651T1/sl unknown
- 2010-06-18 DK DK10789873.6T patent/DK2442651T3/en active
- 2010-06-18 AU AU2010260455A patent/AU2010260455A1/en not_active Abandoned
- 2010-06-18 HU HUE10789873A patent/HUE026406T2/hu unknown
- 2010-06-18 SG SG2011092483A patent/SG176840A1/en unknown
- 2010-06-18 KR KR1020127001253A patent/KR20120037477A/ko active Application Filing
- 2010-06-18 ES ES10789873.6T patent/ES2548999T3/es active Active
- 2010-06-18 KR KR1020177026329A patent/KR20170109091A/ko not_active Application Discontinuation
- 2010-06-18 JP JP2012516065A patent/JP2012530701A/ja not_active Withdrawn
- 2010-06-18 CN CN201710171011.XA patent/CN107308162A/zh active Pending
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2011
- 2011-12-06 IL IL216780A patent/IL216780A0/en unknown
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2012
- 2012-01-03 ZA ZA2012/00029A patent/ZA201200029B/en unknown
- 2012-10-11 HK HK12110013.8A patent/HK1169563A1/xx not_active IP Right Cessation
- 2012-12-12 US US13/712,398 patent/US20130272996A1/en not_active Abandoned
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2013
- 2013-12-20 US US14/137,778 patent/US20140105850A1/en not_active Abandoned
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2014
- 2014-12-25 JP JP2014263274A patent/JP2015107981A/ja not_active Withdrawn
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2015
- 2015-03-02 US US14/635,837 patent/US20150164880A1/en not_active Abandoned
- 2015-09-18 HR HRP20150988TT patent/HRP20150988T1/hr unknown
- 2015-09-30 CY CY20151100869T patent/CY1116727T1/el unknown
- 2015-10-23 SM SM201500262T patent/SMT201500262B/it unknown
- 2015-12-04 US US14/959,845 patent/US20160082001A1/en not_active Abandoned
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2016
- 2016-06-01 JP JP2016110233A patent/JP2016199555A/ja active Pending
- 2016-08-16 AU AU2016216586A patent/AU2016216586A1/en not_active Abandoned
- 2016-11-28 US US15/362,535 patent/US20170128435A1/en not_active Abandoned
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2017
- 2017-06-06 IL IL252699A patent/IL252699A0/en unknown
- 2017-08-10 JP JP2017155343A patent/JP2018021045A/ja not_active Withdrawn
- 2017-09-11 US US15/701,157 patent/US20180042916A1/en not_active Abandoned
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